Collective effects in force generation by multiple cytoskeletal filaments pushing an obstacle

Aparna, J. S.; Das, Debapratim; Padinhateeri, Ranjith; Das, Dibyendu

doi:10.1088/1742-6596/638/1/012012

Cited by 1 publication

(1 citation statement)

References 17 publications

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“…Some of these theoretical studies have demonstrated that the stall force of multiple, non-interacting filaments without ATP/GTP dynamics, scales linearly with the number of filaments [26,[28][29][30]54]. In contrast, a few other recent papers quite clearly report that inclusion of ATP/GTP hydrolysis can lead to either enhanced or reduced cooperativity in the maximum force generated by multiple growing filaments; the stall forces need not always scale with the number of filaments [31,[56][57][58]. In other words, the stall forces of individual filaments are non-additive in general, that is, the collective stall force produced by N number of filaments (denoted by f (N ) s ) is not just a simple sum of individual stall forces of single filaments (i.e., f (N )…”

Section: Introductionmentioning

confidence: 99%

Sufficient conditions for the additivity of stall forces generated by multiple filaments or motors

Bameta

Das

et al. 2017

Phys. Rev. E

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Molecular motors and cytoskeletal filaments work collectively most of the time under opposing forces. This opposing force may be due to cargo carried by motors or resistance coming from the cell membrane pressing against the cytoskeletal filaments. Some recent studies have shown that the collective maximum force (stall force) generated by multiple cytoskeletal filaments or molecular motors may not always be just a simple sum of the stall forces of the individual filaments or motors. To understand this excess or deficit in the collective force, we study a broad class of models of both cytoskeletal filaments and molecular motors. We argue that the stall force generated by a group of filaments or motors is additive, that is, the stall force of N number of filaments (motors) is N times the stall force of one filament (motor), when the system is in equilibrium at stall. Conversely, we show that this additive property typically does not hold true when the system is not at equilibrium at stall. We thus present a novel and unified understanding of the existing models exhibiting such nonaddivity, and generalise our arguments by developing new models that demonstrate this phenomena. We also propose a quantity similar to thermodynamic efficiency to easily predict this deviation from stall-force additivity for filament and motor collectives.

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