Collimator design for experimental minibeam radiation therapy

Babcock, Kerry; Sidhu, Narinder; Kundapur, Vijayananda; Ali, Kaiser

doi:10.1118/1.3560425

Cited by 14 publications

(14 citation statements)

References 25 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To extrapolate the knowledge learned from SMBRT studies and move towards human use, in 2009 a tungsten collimator was designed to produce a beam of 1,000 lm size that was named a ''mini beam'', and could be used with an RT-250 superficial X-ray machine (24). This was the first step towards realizing the goal of using this new medical technology for the treatment of human cancers.…”

Section: Introductionmentioning

confidence: 99%

Is Mini Beam Ready for Human Trials? Results of Randomized Study of Treating De-Novo Brain Tumors in Canines Using Linear Accelerator Generated Mini Beams

Kundapur

Mayer²,

Auer

et al. 2022

Radiation Research

View full text Add to dashboard Cite

The main challenge in treating malignant brain neoplasms lies in eradicating the tumor while minimizing treatment-related damage. Conventional radiation treatments are associated with considerable side effects. Synchrotron generated micro-beam radiation (SMBRT) has shown to preserve brain architecture while killing tumor cells, however physical characteristics and limited facility access restrict its use. We have created a new clinical device which produces mini beams on a linear accelerator, to provide a new type of treatment called mini-beam radiation therapy (MBRT). The objective of this study is to compare the treatment outcomes of linear accelerator based MBRT versus standard radiation treatment (SRT), to evaluate the tumor response and the treatment-related changes in the normal brain with respect to each treatment type. Pet dogs with de-novo brain tumors were accrued for treatment. Dogs were randomized between standard fractionated stereotactic (9 Gy in 3 fractions) radiation treatment vs. a single fraction of MBRT (26 Gy mean dose). Dogs were monitored after treatment for clinical assessment and imaging. When the dogs were euthanized, a veterinary pathologist assessed the radiation changes and tumor response. We accrued 16 dogs, 8 dogs in each treatment arm. In the MBRT arm, 71% dogs achieved complete pathological remission. The radiation-related changes were all confined to the target region. Structural damage was not observed in the beam path outside of the target region. In contrast, none of the dogs in control group achieved remission and the treatment related damage was more extensive. Therapeutic superiority was observed with MBRT, including both tumor control and the normal structural preservation. The MBRT findings are suggestive of an immune related mechanism which is absent in standard treatment. These findings together with the widespread availability of clinical linear accelerators make MBRT a promising research topic to explore further treatment and clinical trial opportunities.

show abstract

Section: Introductionmentioning

confidence: 99%

Is Mini Beam Ready for Human Trials? Results of Randomized Study of Treating De-Novo Brain Tumors in Canines Using Linear Accelerator Generated Mini Beams

Kundapur

Mayer²,

Auer

et al. 2022

Radiation Research

View full text Add to dashboard Cite

show abstract

“…Nevertheless, the low dose rate, the strongly divergent radiation field, and the large source size of conventional x-ray tubes are a challenge for experiments with microbeams. Most existing x-ray tubeebased systems provide only larger beam widths greater than 100 mm, [18][19][20] which are typically referred to as minibeams, at dose rates less than 5 Gy/min. With carbon nanotube sources, MRT treatments of mice at low dose rates have successfully been carried out 21 and demonstrated that the effect of motioninduced dose blurring for microbeams can be limited by proper fixation of the animals during irradiation.…”

Section: Introductionmentioning

confidence: 99%

Establishment of Microbeam Radiation Therapy at a Small-Animal Irradiator

Treibel

Nguyen

Ahmed

et al. 2021

International Journal of Radiation Oncology*Biology*Physics

View full text Add to dashboard Cite

“…Several investigators developed compact microbeam systems for preclinical research [200,201] . However, most of these preclinical systems have larger aperture widths and should therefore rather be classified as minibeam systems.…”

mentioning

confidence: 99%