Colloid (mucinous non-cystic) carcinoma of the pancreas: A case report

Abstract

Abstract. Colloid carcinoma (CC) of the pancreas, also known as mucinous non-cystic carcinoma, is a rare histological variant of pancreatic cancer. The present study reports the case of a 65-year-old male with a pancreatic head tumor 4.6x3.1 cm in size. The tumor had not invaded the superior mesenteric or celiac arteries. Laboratory data showed elevated alkaline phosphatase, γ-gluytamyl transpeptidase and cancer antigen 19-9 (CA19-9) levels. The patient underwent a pancreaticoduodenectomy (PD), and the pathology revealed CC extending to the submucosa of the duodenum, with mild atypical hyperplasia of the pancreatic duct. The patient was negative for circulating tumor cells, indicating a good prognosis. The CA19-9 concentration decreased to within the normal range following surgery. The present study reports a rare case of CC of the pancreas presenting with obstructive jaundice, in which a PD procedure was performed. Primary surgical treatment with curative intent is the optimal management and this subtype of pancreatic cancer is associated with a better prognosis compared with pancreatic ductal adenocarcinoma.

Colloid Carcinoma of the Pancreas: Case Report and Review of the Literature

“…Due to the rarity of the diagnosis, colloid carcinomas are typically diagnosed after surgical resection, rather than on preoperative workup. Clinical presentation of patients with IPMN-associated carcinomas and ductal adenocarcinoma has been reported to be similar, 3,11,12 with presentation in about the seventh decade of life and with similar presenting symptoms of abdominal pain, jaundice, and weight loss. There may be a slight male predilection in colloid carcinoma.…”

Pancreatic Colloid Carcinoma Presenting with Acute Pancreatitis

“…According to the Armed Forces Institute of Pathology (AFIP) definition established in 2007, the colloid component of colloid carcinoma should comprise at least 80% of the neoplasm (1). Colloid carcinomas most often develop in the head of the pancreas (2). The diameter of colloid carcinoma ranges between 1.2 and 16.0 cm, which is greater than that of tubular ductal adenocarcinoma at presentation (2,3,6).…”

“…A microscopic investigation of pancreatic colloid carcinoma reveals that the tumors consist of separating pools containing mucin and floating clumps or strands of malignant cells; the mucin pools are lined in part by the cuboidal or well-differentiated epithelium (2). According to the Armed Forces Institute of Pathology (AFIP) definition established in 2007, the colloid component of colloid carcinoma should comprise at least 80% of the neoplasm (1).…”

“…Colloid carcinomas most often develop in the head of the pancreas (2). The diameter of colloid carcinoma ranges between 1.2 and 16.0 cm, which is greater than that of tubular ductal adenocarcinoma at presentation (2,3,6). Pancreatic colloid carcinoma is derived from a subtype of invasive pancreatic ductal adenocarcinoma, IPMN and mucinous cystic neoplasm (MCN).…”

“…It is a rare subtype of pancreatic cancer that only accounts for only 1%-3% of the malignant neoplasms of the exocrine pancreas. The incidence is suspected to be only a few cases per 1 million individuals per yea (2)(3)(4). The clinical manifestations of pancreatic colloid carcinoma are similar to those of invasive pancreatic adenocarcinoma; however, the histopathology has unique features (2).…”