Colloidal characteristics and functionality of rationally designed esculin-loaded hydrogel microcapsules

Tsirigotis-Maniecka, Marta; Szyk-Warszyńska, Lilianna; Michna, Aneta; Warszyński, Piotr; Wilk, Kazimiera A.

doi:10.1016/j.jcis.2018.07.006

Cited by 25 publications

(16 citation statements)

References 49 publications

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“…At selected time intervals, the mass of the microparticles was measured. The swelling index ( SI ) was calculated using the following equation:

where m T represents the measured mass of the microparticles at the selected time point, while m RH represents the mass of the rehydrated microparticles [ 21 ].…”

Section: Methodsmentioning

confidence: 99%

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Alginate-, Carboxymethyl Cellulose-, and κ-Carrageenan-Based Microparticles as Storage Vehicles for Cranberry Extract

Tsirigotis-Maniecka

2020

Molecules

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This study discusses the relationship between the structural properties of the selected polysaccharides (low (ALGLV) and medium viscosity (ALGMV) sodium alginate, 90 kDa (CMC90) and 250 kDa (CMC250) carboxymethyl cellulose, and κ-carrageenan (CARκ)) and their abilities to serve as protective materials of encapsulated large cranberry (Vaccinium macrocarpon Aiton) fruit extract (CE) from losing its health beneficial activities during long-term storage. The microparticles were characterized in terms of their encapsulation efficiency (UV-Vis and FTIR), morphology (SEM) and the physical stability in various environments (gravimetry). The microparticles’ size and encapsulation efficiency were 46–50 µm and 28–58%, respectively, and the microparticles were physically stable. CMC90 and ALGMV most efficiently protected the plant extract from losing its biological activity after 18 months, while the plant extract stored outside the particles had lost its activity. CE was intended for oral administration, thus CE release from the microparticles was monitored in vitro under gastrointestinal conditions. In vitro gastrointestinal release studies revealed that the ALGMV-, CMC90-, and CMC250-based particles exhibited the desired intestinal release pattern. This result supports the suitability of sodium alginate and carboxymethyl cellulose for the safe delivery of CE to the intestines while maintaining its biological properties and improving long-term storage stability.

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“…At selected time intervals, the mass of the microparticles was measured. The swelling index ( SI ) was calculated using the following equation:

where m T represents the measured mass of the microparticles at the selected time point, while m RH represents the mass of the rehydrated microparticles [ 21 ].…”

Section: Methodsmentioning

confidence: 99%

“…Additionally, the results indicate which of the utilized polysaccharides is most compatible with CE. This study is a continuation of current research focused on developing multipurpose, biopolymeric hydrogel microcarriers designed to prevent the loss of the nutritional and functional potential of phytopharmaceuticals [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Alginate-, Carboxymethyl Cellulose-, and κ-Carrageenan-Based Microparticles as Storage Vehicles for Cranberry Extract

Tsirigotis-Maniecka

2020

Molecules

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“…Particularly, chitosan (CHIT) and gelatin (GEL) are of considerable interests among various substances valuable as a building blocks for DDS [ 18 , 19 ]. Being appropriately charged polyelectrolytes capable of electrostatic interactions with the alginate (ALG) core, CHIT and GEL are often selected as coating materials for ALG-based particles and their suitability was confirmed in our previous study [ 20 ]. Encapsulation in biopolymer-based vehicles often occurs under mild aqueous conditions, without toxic solvents.…”

Section: Introductionmentioning

confidence: 99%

Microparticles vs. Macroparticles as Curcumin Delivery Vehicles: Structural Studies and Cytotoxic Effect in Human Adenocarcinoma Cell Line (LoVo)

et al. 2021

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This study aimed to characterize the hydrogel micro- and macro-particles designed to deliver curcumin to human colon cancer cells (LoVo). Six series of vehicles based on sodium alginate (micro- and macro-particles, uncoated, coated with chitosan or gelatin) were synthesized. The uncoated microparticles were fabricated using an emulsion-based technique and the uncoated macroparticles with an extrusion technique, with both coupled with ionotropic gelation. The surface morphology of the particles was examined with scanning electron microscopy and the average size was measured. The encapsulation efficiency, moisture content, and swelling index were calculated. The release of curcumin from the particles was studied in an experiment simulating the conditions of the stomach, intestine, and colon. To evaluate the anticancer properties of such targeted drug delivery systems, the cytotoxicity of both curcumin-loaded and unloaded carriers to human colon cancer cells was assessed. The microparticles encapsulated much less of the payload than the macroparticles and released their content in a more prolonged manner. The unloaded carriers were not cytotoxic to LoVo cells, while the curcumin-loaded vehicles impaired their viability—more significantly after incubation with microparticles compared to macroparticles. Gelatin-coated or uncoated microparticles were the most promising carriers but their potential anticancer activity requires further thorough investigation.

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“…Alginate microgels have a wide variety of pharmaceutical and biomedical applications, such as delivery vehicles of natural medicine [1,2], liquid metal droplets [3], protein [4,5], hydrophilic and hydrophobic drugs [6], MR imaging [7], cell encapsulation [8,9] and biocatalyst [10], due to its advantageous features of biocompatibility, low toxicity [11], low cost, magnetic property, controlled release [12] and stimuli-response [13,14]. Alginate hydrogels have three synthesis methods, including ionic cross-linking gelation, covalent cross-linking gelation and thermal gelation, in which ionic cross-linking gelation is the most frequently-used method [15].…”

Section: Introductionmentioning

confidence: 99%

3D-Printed Concentration-Controlled Microfluidic Chip with Diffusion Mixing Pattern for the Synthesis of Alginate Drug Delivery Microgels

Cai

Shi

et al. 2019

Nanomaterials

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Alginate as a good drug delivery vehicle has excellent biocompatibility and biodegradability. In the ionic gelation process between alginate and Ca2+, the violent reaction is the absence of a well-controlled strategy in the synthesizing calcium alginate (CaA) microgels. In this study, a concentration-controlled microfluidic chip with central buffer flow was designed and 3D-printed to well-control the synthesis process of CaA microgels by the diffusion mixing pattern. The diffusion mixing pattern in the microfluidic chip can slow down the ionic gelation process in the central stream. The particle size can be influenced by channel length and flow rate ratio, which can be regulated to 448 nm in length and 235 nm in diameter. The delivery ratio of Doxorubicin (Dox) in CaA microgels are up to 90% based on the central stream strategy. CaA@Dox microgels with pH-dependent release property significantly enhances the cell killing rate against human breast cancer cells (MCF-7). The diffusion mixing pattern gives rise to well-controlled synthesis of CaA microgels, serving as a continuous and controllable production process for advanced drug delivery systems.

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Colloidal characteristics and functionality of rationally designed esculin-loaded hydrogel microcapsules

Cited by 25 publications

References 49 publications

Alginate-, Carboxymethyl Cellulose-, and κ-Carrageenan-Based Microparticles as Storage Vehicles for Cranberry Extract

Alginate-, Carboxymethyl Cellulose-, and κ-Carrageenan-Based Microparticles as Storage Vehicles for Cranberry Extract

Microparticles vs. Macroparticles as Curcumin Delivery Vehicles: Structural Studies and Cytotoxic Effect in Human Adenocarcinoma Cell Line (LoVo)

3D-Printed Concentration-Controlled Microfluidic Chip with Diffusion Mixing Pattern for the Synthesis of Alginate Drug Delivery Microgels

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