Colloidal Stability and Monodispersible Magnetic Iron Oxide Nanoparticles in Biotechnology Application

Abstract

Magnetic iron oxide nanoparticles are promising material for various biological applications. In the recent decades, magnetic iron oxide nanoparticles (MNPs) have great attention in biomedical applications such as drug delivery, magnetic resonance imaging (MRI) and magnetic°uid hyperthermia (MFH). This review focuses on the colloidal stability and monodispersity properties of MNPs, which pay more attention toward biomedical applications. The simplest and the most promising method for the synthesis of MNPs is co-precipitation. The biocompatible MNPs are more interested in MRI application. This review also apportions synthesis, characterization and applications of MNP in biological and biomedical as theranostics and imaging.

A biotechnological perspective on the application of iron oxide nanoparticles

“…MNPs are composed of magnetic elements (iron, nickel, or cobalt) and their oxides (magnetite (Fe 3 O 4 ), maghemite (γ-Fe 2 O 3 ), and cobalt ferrite (Fe 2 CoO 4 )) [4]. Magnetic materials are classified as five main types.…”

“…The particle size, size distribution, shape, and surface area are the special properties of MNPs that play an important role in biological applications [4]. Particle size is the most important characteristic of NPs.…”

Functional probes for cardiovascular molecular imaging

“…Moreover, the surface-functionalized nanoparticles with polyethylene glycol (PEG), promote the bioconjugation with various ligands including drug molecules. Several steps have been taken to reduce the risks posed by nanomaterials in order to enable the novel formulation of highly biocompatible and less toxic nanomedicines (e.g., silica nanoparticles) (25).…”