Colon and gut microbiota greatly affect the absorption and utilization of astaxanthin derived from Haematococcus pluvialis

Li, Chunjun; Gao, Yuan; Huan, Yuchen; Ren, Pengfei; Zhi, Jinjin; Wu, Axue; Xu, Jie; Wei, Zihao; Xue, Changhu; Tang, Qingjuan

doi:10.1016/j.foodres.2022.111324

Cited by 15 publications

(12 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…29,46,47 Previous research conducted by our team has also confirmed the influence of astaxanthin on the proliferation of Akkermansia. [16][17][18]48 The pro-proliferative action of astaxanthin on Akkermansia and its increase of organismal immunity. The promotion of the antitumor immune response to sorafenib may be facilitated by astaxanthin through this potential mechanism.…”

Section: Discussionmentioning

confidence: 99%

“…16 A fundamental factor contributing to this phenomenon appears to be the influence of astaxanthin on the composition and function of gut microbiota. 16–18…”

Section: Introductionmentioning

confidence: 99%

“…16 A fundamental factor contributing to this phenomenon appears to be the influence of astaxanthin on the composition and function of gut microbiota. [16][17][18] A recent study conducted by our research group has validated that the dietary supplement of astaxanthin for mice with hepatocellular carcinoma undergoing sorafenib treatment can augment the drug's anti-tumor effects and ameliorate cachexia symptoms, including skeletal muscle atrophy and weight loss in tumor-bearing mice. 19 However, the potential of astaxanthin as an immunomodulator to enhance the antitumor immune response of the molecularly targeted drug sorafenib and the specific mechanism by which it augments the antitumor effects of the drug remain unknown.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Dietary supplementation with astaxanthin enhances anti-tumor immune response and aids the enhancement of molecularly targeted therapy for hepatocellular carcinoma

Ren,

Yu,

Yue

et al. 2023

Food Funct.

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…16 A fundamental factor contributing to this phenomenon appears to be the influence of astaxanthin on the composition and function of gut microbiota. 16–18…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dietary supplementation with astaxanthin enhances anti-tumor immune response and aids the enhancement of molecularly targeted therapy for hepatocellular carcinoma

Ren,

Yu,

Yue

et al. 2023

Food Funct.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Siphonein was certainly absorbed without hydrolysis, but we also showed that it underwent hydrolysis at some point in vivo. Recently, Li et al reported that mouse colonic microbiota could hydrolyze astaxanthin fatty acid esters during a 24-h of anaerobic culture (35). Hence, not only digestive enzymes but also gut microbiota could hydrolyze siphonein in the gastrointestinal tract.…”

Section: Discussionmentioning

confidence: 99%

“…All animal care and experimental procedures in this study were conducted in accordance with protocols approved by the Kyoto University Animal Committee (approval No. [31][32][33][34][35][36][37]. Male ICR mice (7 wk old) were obtained from Japan SLC, Inc. (Shizu oka, Japan).…”

Section: Methodsmentioning

confidence: 99%

Intestinal Absorption and Anti-Inflammatory Effects of Siphonein, a Siphonaxanthin Fatty Acid Ester from Green Algae

Manabe

TAKAGI-HAYASHI

Mohri

et al. 2023

J Nutr Sci Vitaminol

View full text Add to dashboard Cite

Siphonein is a C19 acylated siphonaxanthin found in some edible green algae (e.g., Codium fragile and Caulerpa lentillifera). Although the content of siphonein in these green algae is similar to or higher than that of siphonaxanthin, studies of health-related biological activity of siphonein are much less than those of siphonaxanthin. Given the difference in the position of the acyl chain, one cannot infer intestinal absorption of siphonein from other general carotenoid fatty acid esters. In this study, we fi rst investigated the intestinal absorption of siphonein using mouse and cell culture models. A small amount of siphonein was detected in the plasma of treated mice, and its concentration was higher than that of siphonaxanthin (i.e., the hydrolyzed product of ingested siphonein) from 1 to 6 h after administration. Pharmacological inhibition tests with differentiated Caco-2 cells showed that Nieman-Pick C1-like 1-mediated facilitated diffusion was involved in the cellular uptake of siphonein. These results indicate that, unlike general carotenoid fatty acid esters, siphonein can be absorbed without hydrolysis. We also evaluated the anti-infl ammatory effect of siphonein in differentiated Caco-2 cells. Siphonein pretreatment modulated lipopolysaccharide-induced cellular lipidome alterations and suppressed mRNA expression of proinfl ammatory chemokines, CXCL8 protein release, and activation of NF-B. This study provides new insights into the absorption processes of carotenoids and shows the anti-infl ammatory effect of siphonein for the fi rst time.

show abstract

Production of new functional coconut milk kefir with blueberry extract and microalgae: the comparison of the prebiotic potentials on lactic acid bacteria of kefir grain and biochemical characteristics

Aktas,

Aydin

2024

J Food Sci Technol

View full text Add to dashboard Cite

Probiotic foods are recognized for their importance on human health. Kefir is a versatile probiotic food that can be made from non-dairy sources for vegan diet. This study evaluated the addition of microalga Haematococcus pluvialis (0.50% w/v) and blueberry Vaccinium myrtillus (0.50% w/v) extracts to compare their influence on the biochemical properties and the bacterial community of coconut milk kefir through Nanopore-based DNA sequencing. Results revealed that the V. myrtillus increased the microbial diversity in coconut milk kefir with more abundant Proteobacteria species such as Lacticaseibacillus paracasei (22%) and Lactococcus lactis (6.3%). Microalga demonstrated the opposite effect on C, making Firmicutes represent the whole of the microbiota. Biochemical analysis revealed increased fat content in the kefir samples, with the C1 registering 1.62% and the 1.07% in C2, in contrast to the control group’s 0.87% fat content. The crude protein content exhibited a decrease in both samples compared to the control group (0.00% and 0.88% versus 1.07%). These findings suggest that fortifying vegan kefir with prebiotics has the potential to induce significant alterations in the kefir microbiota. Graphical abstract

show abstract

Colon and gut microbiota greatly affect the absorption and utilization of astaxanthin derived from Haematococcus pluvialis

Cited by 15 publications

References 41 publications

Dietary supplementation with astaxanthin enhances anti-tumor immune response and aids the enhancement of molecularly targeted therapy for hepatocellular carcinoma

Dietary supplementation with astaxanthin enhances anti-tumor immune response and aids the enhancement of molecularly targeted therapy for hepatocellular carcinoma

Intestinal Absorption and Anti-Inflammatory Effects of Siphonein, a Siphonaxanthin Fatty Acid Ester from Green Algae

Production of new functional coconut milk kefir with blueberry extract and microalgae: the comparison of the prebiotic potentials on lactic acid bacteria of kefir grain and biochemical characteristics

Contact Info

Product

Resources

About