Colon cancer survival in the US Department of Veterans Affairs by race and stage: 2001 through 2009

Azar, Ibrahim; Esfandiarifard, Saghi; Sinai, Pedram; Mehdi, Syed

doi:10.1002/cncr.31525

Cited by 3 publications

(2 citation statements)

References 1 publication

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“…In studies conducted in equal care settings, such as the Veterans Health Administration (VA) in the US, there was no difference between Black and White individuals regarding the stage distribution at diagnosis, overall and stage-specific five-year survival. 28,29 Similar results are reported in other disease settings, and populations. 30 Collectively, the findings underpin the hypothesis that the Black-vs-White differences in cancer survival may reflect inequalities in access to screening and treatment, rather than differences in cancer biology -as race is not a biological construct.…”

Section: Socio-economic Determinants Of Health (Sdh)supporting

confidence: 84%

There is no such a thing as a ‘biological’ basis for cancer disparities: A call to end misreporting of the ultimate determinants of health outcomes

Trapani,

Girardi,

Cinieri

et al. 2023

Tumori

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Improved strategies of cancer prevention and control have resulted in tangible benefits for patients with cancer. Disparities in outcome have been reported as a result of inequal access to health care. Historically, differences in health outcomes at population level have been reported according to key characteristics, including race, ethnicity and, more recently, ancestry. These population descriptors have been used to display the differences in the outcome and highlight actionable areas of health disparities, through policy and population health interventions. Yet, they have been commonly mis-intended as ultimate determinants of health outcomes, as recapitulating intrinsic biological differences. A plethora of past literature has described “biological” differences in patients belonging to a specific racial, ethnical or ancestral group, with certain cancers - commonly overlooking the social and economic contextures. The attention has ultimately focused on the existence of intrinsic differences and biological reasons, as opposed to social and economic determinants of disparities in the outcome in disadvantaged or excluded communities, thus nurturing double stigma. In our editorial, we evaluate some key roots of racial attitudes in displaying patient outcomes in oncology epidemiological studies, and call to report ultimate determinants of health – that are, primarily social and economic determinants.

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Section: Socio-economic Determinants Of Health (Sdh)supporting

confidence: 84%

There is no such a thing as a ‘biological’ basis for cancer disparities: A call to end misreporting of the ultimate determinants of health outcomes

Trapani,

Girardi,

Cinieri

et al. 2023

Tumori

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show abstract

“… 3 Currently, although many treatment approaches have increased the life quality of patients with COAD, the 5-year survival rate is still poor, 4 , 5 Late diagnosis and lack of effective therapeutic targets are the main obstacles to COAD treatment. 6 , 7 Hence, reliable biomarkers and specific therapeutic targets affirmatively help improve diagnosis and decrease death rate in COAD patients. 8 , 9 Therefore, it is urgent to investigating the molecular mechanism of COAD tumorigenesis, which may provide new treatment targets and prognostic biomarkers.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-148a-3p Directly Targets SERPINE1 to Suppress EMT-Mediated Colon Adenocarcinoma Progression

Chen

Wang

et al. 2021

CMAR

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Aim This research aimed at clarifying the intracellular effect of SERPINE1 in the progression of colon adenocarcinoma (COAD) and the underlying mechanism. Methods We obtained the expression profile of SERPINE1 in COAD via the Starbase database and verified it on COAD tissue samples through qRT-PCR and immunoblotting, respectively. Also, miRWalk, TargetScan and miRDB databases were adopted to generate the miRNA prediction that might target SERPINE1, and the gene target miR-148a-3p was confirmed using dual-luciferase assays. The effect of SERPINE1 and miR-148a-3p on COAD was further evaluated by cell experiments. MTT assay was used to detect the change of cell proliferation ability. The invasive and migratory capability of COAD cells was examined using transwell and would healing assays. Cell apoptosis was determined through flow cytometry. The expressions of genes and EMT-associated proteins were evaluated by qRT-PCR and immunoblotting. Further lucubration of the biological relevance of SERPINE1 and miR-148a-3p was conducted using rescue experiments. Results We found that the expression quantities of SERPINE1 in COAD tissues and cell lines were higher than those in corresponding non-cancerous tissues and normal cells. When SERPINE1 expression is reduced, EMT process is inhibited, invasion and proliferation ability of COAD cells are obviously reduced, and apoptosis level is increased. Moreover, SERPINE1 was identified as the target gene of miR-148a-3p. When the expression of miR-148a-3p was enhanced, it was found that the expression of SERPINE1 was reduced. miR-148a-3p played the similar effect of si-SERPINE1 that suppressed the COAD progression. Additionally, we found out that SERPINE1 is validated in hindering the tumor healing effect of miR148a-3p in COAD, including cell growth and invasion. Conclusion Our study suggests that SERPINE1/miR-148a-3p axis has potential as prognostic markers of COAD and provides reference for the development of new therapies.

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Comprehensive Analysis for Identifying Diagnostic and Prognostic Biomarkers in Colon Adenocarcinoma

Liu

Bai

Xie

et al. 2020

DNA and Cell Biology

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Colon cancer survival in the US Department of Veterans Affairs by race and stage: 2001 through 2009

Cited by 3 publications

References 1 publication

There is no such a thing as a ‘biological’ basis for cancer disparities: A call to end misreporting of the ultimate determinants of health outcomes

There is no such a thing as a ‘biological’ basis for cancer disparities: A call to end misreporting of the ultimate determinants of health outcomes

MicroRNA-148a-3p Directly Targets SERPINE1 to Suppress EMT-Mediated Colon Adenocarcinoma Progression

Comprehensive Analysis for Identifying Diagnostic and Prognostic Biomarkers in Colon Adenocarcinoma

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