Colon Targeting Using pH Sensitive Materials

Jain, Ashish

doi:10.19080/argh.2018.08.555748

Cited by 5 publications

(4 citation statements)

References 9 publications

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“…Targeted drug delivery is one of the important research fields in modern pharmaceutical and medical sciences. Methacrylate copolymers (Eudragit ® ) are an appropriate choice for the development of intestinal targeted drug delivery systems; they are pH-responsive enteric polymers that can be exploited to target different regions of the intestine for the treatment of many diseases such as inflammatory bowel disease (IBD) and colorectal cancer [12].…”

Section: Introductionmentioning

confidence: 99%

Co-Loading of Ascorbic Acid and Tocopherol in Eudragit-Nutriosomes to Counteract Intestinal Oxidative Stress

et al. 2019

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The present study aimed at developing a new vesicular formulation capable of promoting the protective effect of ascorbic acid and tocopherol against intestinal oxidative stress damage, and their efficacy in intestinal wound healing upon oral administration. A pH-dependent copolymer (Eudragit® L100), a water-soluble prebiotic fibre (Nutriose® FM06), a phospholipid mixture (Lipoid S75), and two natural antioxidants (ascorbic acid and tocopherol) were combined to fabricate eudragit-nutriosomes by a simple, solvent-free procedure. The vesicles were spherical and oligolamellar, with some multicompartment structures in Eudragit-nutriosomes, small in size (~100 nm), with highly negative zeta potential. The effect of Eudragit® and Nutriose® on the stability on storage and in simulated gastrointestinal fluids were confirmed by the Turbiscan® technology and in vitro studies, respectively. Eudragit-nutriosomes exhibited a protective effect against H2O2-induced oxidative stress, and a proliferative effect in Caco-2 cells, as they provided the closure of the scratched area after 96 h of incubation.

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Section: Introductionmentioning

confidence: 99%

Co-Loading of Ascorbic Acid and Tocopherol in Eudragit-Nutriosomes to Counteract Intestinal Oxidative Stress

et al. 2019

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“…It was previously demonstrated that the combination of phospholipid vesicles with polymers (i.e. hyaluronic acid) or fibres, improved the local bioavailability of natural bioactives after oral administration 35,82,83 .…”

Section: Discussionmentioning

confidence: 99%

From waste to health: sustainable exploitation of grape pomace seed extract to manufacture antioxidant, regenerative and prebiotic nanovesicles within circular economy

Manca

Casula

Marongiu

et al. 2020

Sci Rep

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pomace seed extract loaded vesicles were prepared as promising technological and green solution to exploit agri-food wastes and by-products, and develop high value-added products for human health. An antioxidant extract rich in bioactive compounds (epicatechins, catechin, gallic acid, quercetin and procynidins) was obtained from the seeds isolated from the pomace of cannonau red grape cultivar. the extract was incorporated into phospholipid vesicles ad hoc formulated for intestinal delivery, by combining them, for the first time, whit a maltodextrin (Glucidex). Glucidex-transfersomes, glucidexhyalurosomes and glucidex-hyalutransferomes were prepared, characterized and tested. Glucidexliposomes were used as reference. All vesicles were small in size (~ 150 nm), homogeneously dispersed and negatively charged. Glucidex-transfersomes and especially glucidex-hyalutransfersomes disclosed an unexpected resistance to acidic pH and high ionic strength, as they maintained their physicochemical properties (size and size distribution) after dilution at pH 1.2 simulating the harsh gastric conditions. Vesicles were highly biocompatible and able to counteract the oxidative damages induced in Caco-2 cells by using hydrogen peroxide. Moreover, they promoted the formation of Lactobacillus reuteri biofilm acting as prebiotic formulation. Overall results suggest the potential of glucidexhyalutransfersomes as food supplements for the treatment of intestinal disorders. The circular economy involves the creation of a closed-loop ecosystem for effective consumption and utilization of resources by the adoption of reduce, reuse, and recycle paradigms 1. According to this paradigm, reducing the generation of wastes through their recycle and reuse as well as the sustainable management and efficient use of natural resources are the main challenges for the modern circular economy. A transition towards a restorative and regenerative economic cycle based on more sustainable practices and reduced environmental impacts of

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“…5 mg PCA-loaded NPs were suspended in 5 ml PBS adjusted to pH 5.0 (mimicking the intratumoural acidic pH) placed into dialysis bags with the two ends tied) ( Walker and Walker 1992 ; Jain 2017 ). The dialysis bags were immersed fully into 40 ml of PBS with constant stirring of 100 rpm.…”

Section: Methodsmentioning

confidence: 99%

Potential use of gold-silver core-shell nanoparticles derived from Garcinia mangostana peel for anticancer compound, protocatechuic acid delivery

Lee

Shameli

Nagao

et al. 2022

Front. Mol. Biosci.

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Colorectal cancer is one of the most killing cancers and this has become a global problem. Current treatment and anticancer drugs cannot specifically target the cancerous cells, thus causing toxicity towards surrounding non-cancer cells. Hence, there is an urgent need to discover a more target-specific therapeutic agent to overcome this problem. Core-shell nanoparticles have emerged as good candidate for anticancer treatment. This study aimed to synthesize core-shell nanoparticles via green method which utilised crude peels extract of Garcinia mangostana as reducing and stabilising agents for drug delivery. Gold-silver core-shell nanoparticles (Au-AgNPs) were synthesized through seed germination process in which gold nanoparticles acted as the seed. A complete coating was observed through transmission electron microscopy (TEM) when the ratio of AuNPs and AgNPs was 1:9. The size of Au-AgNPs was 38.22 ± 8.41 nm and was mostly spherical in shape. Plant-based drug, protocatechuic acid (PCA) was loaded on the Au-AgNPs to investigate their anticancer activity. In HCT116 colon cancer cells, PCA-loaded Au-AgNPs (IC50 = 10.78 μg/ml) showed higher inhibitory action than the free PCA (IC50= 148.09 μg/ml) and Au-AgNPs alone (IC50= 24.36 μg/ml). Up to 80% inhibition of HCT116 cells was observed after the treatment of PCA-loaded Au-AgNPs at 15.63 μg/ml. The PCA-loaded Au-AgNPs also showed a better selectivity towards HCT116 compared to CCD112 colon normal cells when tested at the same concentrations. These findings suggest that Au-AgNPs system can be used as a potent nanocarrier to combat cancerous cells by offering additional anticancer properties to the loaded drug.

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Colon Targeting Using pH Sensitive Materials

Cited by 5 publications

References 9 publications

Co-Loading of Ascorbic Acid and Tocopherol in Eudragit-Nutriosomes to Counteract Intestinal Oxidative Stress

Co-Loading of Ascorbic Acid and Tocopherol in Eudragit-Nutriosomes to Counteract Intestinal Oxidative Stress

From waste to health: sustainable exploitation of grape pomace seed extract to manufacture antioxidant, regenerative and prebiotic nanovesicles within circular economy

Potential use of gold-silver core-shell nanoparticles derived from Garcinia mangostana peel for anticancer compound, protocatechuic acid delivery

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