Colonic adenocarcinoma associated with the acquired immune deficiency syndrome

Cappell, Mitchell S.; Yao, Francis Y.; Cho, Kyunghee C.

doi:10.1002/1097-0142(19880801)62:3<616::aid-cncr2820620329>3.0.co;2-j

Cited by 39 publications

(21 citation statements)

References 20 publications

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“…11 Furthermore, a few studies suggest that colorectal cancers may present with more aggressive behavior with HIV. [12][13][14] Thus, it is possible that the risk of cancer is elevated with an AIDS-defining opportunistic intestinal infection, due to the infection's associated sustained inflammatory response. Therefore, we analyzed the impact of AIDS-defining intestinal infections on risk of colon cancer using the HIV/AIDS Cancer Match Study data.…”

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confidence: 99%

Opportunistic Intestinal Infections and Risk of Colorectal Cancer Among People with AIDS

Shebl

Engels

Goedert

2012

AIDS Research and Human Retroviruses

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Because mucosal inflammation contributes to colorectal carcinogenesis, we studied the impact of intestinal infections on risk of this malignancy among people with AIDS (PWA). Using the population-based HIV/AIDS Cancer Match, which includes approximately half of all PWA in the United States, the cancer registries ascertained colorectal cancers (ICD-O3 codes C180-C189, C199, C209, and C260). During 4-120 months after AIDS onset, risk of cancer occurring after AIDS-defining intestinal infections (considered as time-dependent exposures) was estimated with hazard ratios (HR) and 95% confidence intervals (CI) calculated by Cox regression. Analyses included cancers overall and by histology and anatomic site. After excluding 118 squamous cell rectal cancers (possible anal cancers), we analyzed 320 incident colorectal cancer cases that occurred among 471,909 PWA. Colorectal cancer risk was marginally elevated following cryptosporidiosis (HR = 2.08, 95% CI = 0.93-4.70, p = 0.08) and mucocutaneous herpes (HR = 1.69, 95% CI = 0.97-2.95, p = 0.07) but not with Pneumocystis pneumonia (HR = 0.79, 95% CI = 0.57-1.10). Cryptosporidiosis was associated with rare colon squamous cell carcinoma [N = 8, HR = 13, 95% CI = 1.5-110] and uncommon histologies [HR = 4.4, 95% CI = 1.1-18, p = 0.04], but it was not associated with colorectal adenocarcinoma (N = 269, HR = 1.3, 95% CI = 0.4-3.9, p = 0.70). Mucocutaneous herpes was associated with colon squamous cell carcinoma (HR = 13, 95% CI = 2.4-67, p = 0.003) but not with colorectal adenocarcinoma (HR = 1.3, 95% CI = 0.6-2.6, p = 0.52) or uncommon histologies (HR = 2.5, 95% CI = 0.8-8.2, p = 0.13). Colon squamous cell carcinoma risk was significantly elevated among PWA who had cryptosporidiosis or mucocutaneous herpes. These findings might suggest that HPV or inflammation from other infection may contribute to carcinogenesis.

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confidence: 99%

Opportunistic Intestinal Infections and Risk of Colorectal Cancer Among People with AIDS

Shebl

Engels

Goedert

2012

AIDS Research and Human Retroviruses

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“…Several authors suggest the presence of aggressive tumor behavior and young age in patients with gastrointestinal cancers associated with HIV infection [3,6,9,10]. Read et al [10] described a 26-year-old homosexual man with AIDS who presented with Listeria monocytogenes sepsis and small-cell carcinoma of the rectum.…”

Section: Discussionmentioning

confidence: 99%

“…Cappell et al [6] reported a 36-year-old man, an intravenous drug abuser, who presented with fatigue and weight loss. He had a large mass in the sigmoid colon, occupying the entire pelvis, involving the urinary bladder, and producing bilateral hydronephrosis.…”

Section: Discussionmentioning

confidence: 99%

“…However, gastrointestinal neoplasms associated with HIV infection are mostly Kaposi's sarcoma or non-Hodgkin's lymphoma, and gastric or colorectal adenocarcinoma is rare [3,4]. Although aggressive and advanced adenocarcinomas of the stomach or colorectum have been reported [5,6], there is no report of early gastric cancer associated with HIV infection.…”

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confidence: 99%

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Gastrectomy for a patient with early gastric cancer and human immunodeficiency virus (HIV) infection

et al. 2001

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thologists, with this condition and operation, we present the clinical, surgical, and pathological data of our patient; we also review the cases in the literature. Case reportA 49-year-old man underwent gastric fiberscopy because of a positive result on a fecal occult blood test. He had a 6-year history of HIV infection, which had been controlled with anti-HIV drugs, including indinavir sulfate ethanolate, lamividine, and sanilvudine. On gastric fiberscopy, there was an irregularly shaped, superficially depressed, IIc-type lesion on the anterior wall of the gastric antrum. Histologic examination of the biopsy specimen showed that the lesion was a well differentiated tubular adenocarcinoma of the stomach. Physical examination revealed no palpable lymph nodes, and total colonoscopy disclosed a small adenomatous polyp of the sigmoid colon. Blood data were as follows: red blood cells, 358 ϫ 10 4 /mm 3 , white blood cells, 6000/mm 3 ; lymphocytes, 27.5%; CD 4ϩ cell count, 530/mm 3 ; CD 4ϩ , 31.2%; CD 8ϩ , 42.2%; CD 4ϩ /CD 8ϩ , 0.74; platelets, 16.9 ϫ 10 4 /mm 3 ; total protein, 8.10 g/dl; albumin, 4.58 g/dl; c-reactive protein (CRP), 0.47 mg/dl; and carcinoembryonic antigen (CEA), 1.3 ng/ml. With a diagnosis of early gastric cancer associated with HIV infection, we carried out Billroth I gastrectomy, on October 16, 2000.At operation, we abided strictly by standard precautions for patients with HIV infection. All surgeons and the assistant nurse wore surgical caps, masks, goggles, gowns, two pairs of gloves, and stockings (Fig. 1). Surgical instruments were handed from assistant nurse to operator, and the knife, needles, and blood-contaminated gauzes were placed in a tray by the operator and emptied into a needle-stick prevention box (Sharps Container XX-ST08B; Terumo, Tokyo, Japan) by the third assistant (Fig. 2). With the patient under general Abstract Gastric cancer associated with human immunodeficiency virus (HIV) infection is rare, and mostly results in a poor outcome. We report a patient with HIV infection and early gastric cancer successufully treated by gastrectomy. A 49-year-old man with a 6-year history of HIV infection underwent gastric fiberscopy, and a IIc-type depressed lesion was detected in the gastric antrum. With a diagnosis of early gastric cancer, we abided strictly by standard precautions for patients with HIV infection and carried out Billroth I gastrectomy. Histologic examination revealed that the lesion (which measured 0.9 ϫ ϫ ϫ ϫ ϫ 0.4 cm in size), was well differentiated tubular adenocarcinoma confined to the mucosa. A review of the literature disclosed that this is the first reported case of early gastric cancer associated with HIV infection.

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“…While some studies have failed to find a link between HIV and gastrointestinal (GI) cancer, several epidemiological studies have demonstrated an elevated risk and earlier age of onset of colonic neoplasia in the HIV-positive population, [1][2][3] including a recent study from the United States that reported a significant increase in colorectal cancer during the period from 2000 to 2003. 4 Further evidence supporting increased gastrointestinal cancer in the context of HIV comes from studies of colorectal precursors and lesions where the increased prevalence of adenomas and advanced neoplasia was recognized when comparing the HIV-positive versus HIVnegative population.…”

Section: Introductionmentioning

confidence: 99%

HIV Infection Accelerates Gastrointestinal Tumor Outgrowth in NSG-HuPBL Mice

Lü

Zhang

et al. 2014

AIDS Research and Human Retroviruses

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HIV infection is a risk factor for the tumorigenesis including non-AIDS-defining cancers such as those of the gastrointestinal tract. However, the mechanisms underlying such cancer outgrowth are still unknown. Furthermore, combined HIV/cancer studies are difficult to evaluate using primate models or in the clinical patient setting. To understand the mechanisms of tumor outgrowth in the context of HIV infection, we adopted a humanized mouse model permissive to infection and cancer as well as an in vivo humanized mouse challenge with colon cancer in the context of HIV infection. Immunodeficient NOD SCID IL-2R

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Colonic adenocarcinoma associated with the acquired immune deficiency syndrome

Cited by 39 publications

References 20 publications

Opportunistic Intestinal Infections and Risk of Colorectal Cancer Among People with AIDS

Opportunistic Intestinal Infections and Risk of Colorectal Cancer Among People with AIDS

Gastrectomy for a patient with early gastric cancer and human immunodeficiency virus (HIV) infection

HIV Infection Accelerates Gastrointestinal Tumor Outgrowth in NSG-HuPBL Mice

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