Colonic Angiosarcoma Arising in Association with Amyloid Deposits

Said, Samar M.; Graham, Rondell P.; Wu, Tsung–Teh; Yasir, Saba; Zhang, Lizhi; Folpe, Andrew L.

doi:10.1155/2020/3780763

Cited by 2 publications

(4 citation statements)

References 54 publications

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“…Patients may also have symptoms of bowel obstruction and weight loss [6,7]. Anemia was present in 42% of patients [6,19]. Our patient had only moderate to severe microcytic anemia.…”

Section: Discussionmentioning

confidence: 66%

“…Before him, Brown et al had similar results [18]. The most common symptoms are gastrointestinal bleeding and abdominal or perianal pain [6,7,19]. Patients may also have symptoms of bowel obstruction and weight loss [6,7].…”

Section: Discussionmentioning

confidence: 91%

“…The etiology of colorectal angiosarcoma is yet unclear. It may be related to long-term exposure to radiation, chemical agents such as polyvinylchloride, thorotrast and arsenic, as well as a consequence of chronic lymphedema and amyloidosis [9,10,11]. Angiosarcoma has also been reported in association with implanted foreign material such as vascular (Dacron) grafts and orthopedic joint prostheses [12,13,14], breast implants [15,16], or in patients with arteriovenous fistulas.…”

Section: Discussionmentioning

confidence: 99%

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Angiosarcoma of the caecum

et al. 2022

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Introduction. Primary angiosarcomas arising from the digestive system are rare, representing less than 1% percent of the malignant sarcomas. Only a few cases have been reported in the literature. Colorectal involvement is exceedingly uncommon and is a harbinger of a poor prognosis with widespread metastasis. Diagnosis is often delayed due to non-specific symptoms and pathology which mimics other tumors. Case outline. In our case, a 52-year-old woman presented to the emergency room in the middle of July 2021, complaining of protracted malaise, and rapid fatigue and occasional sweating. MSCT of the abdomen and small pelvis revealed the existence of lobular, well vascularized, heterodensal lesion, located supravesically along the anterior contour of the uterine corpus, in the convolutes of the small intestine. Patient was subjected to operative treatment with curative intent. Intraoperatively, a completely tumor-altered caecum was verified Standard histopathological examination demonstrated a high grade epitheloid angiosarcoma with severe pleomorphism and solid growth pattern. The control MSCT of abdomen and small pelvis which was done 12 months after the operation did not show the existence of any pathological lesions. Conclusion. Both clinical and pathological diagnoses of colorectal angiosarcoma are challenging. Patients are presented with nonspecific symptoms, which can lead to mismanagement and late diagnosis. A pathological diagnosis relies on immunohistochemical staining for endothelial markers. In limited tissue biopsies, it can be easily misdiagnosed as poorly differentiated adenocarcinoma or gastrointestinal stromal tumor. For now, surgical treatment with R0 resection seems to be the only effective treatment modality.

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“…Patients may also have symptoms of bowel obstruction and weight loss [6,7]. Anemia was present in 42% of patients [6,19]. Our patient had only moderate to severe microcytic anemia.…”

Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Angiosarcoma of the caecum

et al. 2022

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“…Angiosarcoma is characterized by its high invasiveness and poor prognosis, and it often metastasizes to the lymph nodes, liver and bone. [ 2 3 ] Unfortunately, some colonic angiosarcomas are misdiagnosed because of atypical endoscopic findings or lack of awareness of the characteristics of the disease. We report such a case to attract the attention of clinicians.…”

Section: Introductionmentioning

confidence: 99%

Angiosarcoma characterized by colonic polyps

Zhao¹,

Pan²,

Wang³

2020

Medicine

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Rationale: Angiosarcoma is a highly invasive tumour with a low incidence rate but high rates of local recurrence and distant metastasis and a poor prognosis. Understanding the endoscopic characteristics of angiosarcoma will help with early diagnosis and treatment of this disease. Patient concerns: The patient was a 77-year-old female who was admitted to the hospital due to recurring melena for 3 months. Outpatient gastroscopy showed that the patient had multiple gastric erosions. Colonoscopy revealed the presence of multiple protruding lesions in the colon and multiple rectal polyps. Pathological biopsy indicated that the patient had a tubular adenoma, which was removed by endoscopic resection. Diagnoses: Postsurgical pathologic assessment suggested that the histological subtype was epithelioid angiosarcoma. Positron emission tomography-computed tomography (PET-CT) revealed multiple metastases in the lymph nodes and bone. Interventions: The patient underwent acid suppression to protect the stomach, fluid supplementation and red blood cell infusion, and subsequently, surgery, radiotherapy and chemotherapy were recommended. The patient's family refused further treatments for the patient and requested discharge. Outcomes: The patient refused further treatment and was not followed-up. Lessons: Colorectal angiosarcoma is an extremely rare and highly malignant tumour, and understanding its endoscopic morphology will help aid in its diagnosis.

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Colonic Angiosarcoma Arising in Association with Amyloid Deposits

Cited by 2 publications

References 54 publications

Angiosarcoma of the caecum

Angiosarcoma of the caecum

Angiosarcoma characterized by colonic polyps

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