Colonic Ganglioneuromatosis in a Steer

Cole, Diane E.; Migaki, G; Leipold, H. W.

doi:10.1177/030098589902700614

Cited by 14 publications

(31 citation statements)

References 5 publications

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“…In summary, intestinal GN is an uncommon disease of the enteric nervous system 1 . Previous reports in the veterinary literature all describe intestinal GN that was limited to the colon 12–14 . To our knowledge, this is the first reported case of GN affecting the small intestine in a dog and it highlights that GN, although rare, should be included as a differential diagnosis in dogs with segmental or diffuse gastrointestinal thickening.…”

Section: Discussionmentioning

confidence: 69%

“…The first case of GN in the small intestine of a dog is described. In previous reports of this rare disorder in domestic animals, the lesions have been confined to the colon 12–14 …”

Section: Discussionmentioning

confidence: 98%

“…In the veterinary literature, solitary ganglioneuromas have been reported in dogs, cats, pigs, horses and cattle, 11 but reports of GN are limited to a dog, 12 a horse 13 and a steer 14 and in all cases it was confined to the colon.…”

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confidence: 99%

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Small intestinal ganglioneuromatosis in a dog

Hazell¹,

Reeves²,

Swift³

2011

Aust Veterinary J

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A 6-week-old Staffordshire Bull Terrier cross was presented with a 4-week history of vomiting and small bowel diarrhoea. Abdominal ultrasound showed thickening of the distal jejunum and ileum. The dog underwent two exploratory laparotomies, during which grossly abnormal sections of intestine were resected. The patient developed septic peritonitis 48 h after the second surgery, caused by dehiscence of an intestinal anastomosis, and was euthanased. All intestinal tissue samples were examined histopathologically and a diagnosis of gastrointestinal ganglioneuromatosis was made. Intestinal ganglioneuromatosis is rare and this case represents a novel occurrence in the small intestine of a dog.

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Section: Discussionmentioning

confidence: 69%

“…The first case of GN in the small intestine of a dog is described. In previous reports of this rare disorder in domestic animals, the lesions have been confined to the colon 12–14 …”

Section: Discussionmentioning

confidence: 98%

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Small intestinal ganglioneuromatosis in a dog

Hazell¹,

Reeves²,

Swift³

2011

Aust Veterinary J

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“…11 In domestic animals, ganglioneuroma is classified a tumor of the peripheral nervous system and is composed of both neuronal and peripheral glial cells. This tumor is rare but has been reported in dogs, 5,6,13 a pig, 18 horses, 1,12 cattle, 2,3,15 and birds. 9 Common sites of origin include intestine, 1,3,5,10,12,13,18 skin, 6 spinal cord, 2 and brachial plexus.…”

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confidence: 99%

A malignant and metastasizing feline cardiac ganglioneuroma

et al. 2012

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Abstract. In the current study, a case of a cardiac ganglioneuroma with systemic metastases in a cat is described. A 12-yearold male neutered Japanese domestic cat was brought to a veterinary hospital for dysorexia, coughing, vomiting, and diarrhea. Ultrasonography revealed a mass adjacent to the right atrium. The animal died of respiratory failure 1 month after the first visit to the hospital. At necropsy, an oval-shaped white mass 1.5 cm in diameter was observed within the right auricle. Diffusely, the right ventricle was infiltrated and thickened by the neoplastic lesion. Histologically, the mass was composed of 3 types of neoplastic cells: spindle cells, large polygonal cells, and small undifferentiated cells. Immunohistochemically, the neoplasia was positive for neuronal markers such as βIII tubulin, S-100a, and protein gene product 9.5. Ultrastructurally, the large polygonal cells were characterized by abundant cytoplasm that included compressed Golgi cisternae and rough endoplasmic reticula and abundant intermediate filaments. A discontinuous basement membrane surrounded the spindle cells. Metastatic foci were found in the lungs, kidney, pancreas, urinary bladder, and adrenal glands. The morphological, immunohistochemical, and ultrastructural characteristics of the tumor cells were consistent with those of ganglioneuroma. The tumor was presumed to originate from the intramural parasympathetic ganglia in the right atrium.

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“…Ganglioneuromas arising from enteric ganglia have been reported in humans and a variety of domestic animal species, including dogs, 5,10,11,16 cats, pigs, 15 and cattle. 2 The literature includes a single report of an intestinal ganglioneuroma in the horse. 1 This case involved a solitary tumor in the small intestine that caused a physical obstruction.…”

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confidence: 99%

Colonic Ganglioneuromatosis in a Horse

et al. 2007

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Abstract. Ganglioneuromas are complex tumors that arise in peripheral ganglia and are composed of well-differentiated neurons, nerve processes, Schwann cells, and enteric glial cells. The term ganglioneuromatosis (GN) denotes a regional or segmental proliferation of ganglioneuromatous tissue. This report describes an 8-year-old mixed breed horse with GN in a 25-cm segment of small colon. Grossly, the lesion consisted of numerous sessile to pedunculated nodules extending from the serosal surface. Histologic examination revealed the nodules to consist of fascicles of spindle-shaped cells consistent with Schwann cells, clusters of neurons, supporting enteric glial cells, and thick bands of perineurial collagen. Most of the nodules coincided with the location of the myenteric plexus and extended through the outer layer of the tunica muscularis to the serosal surface. Neuronal processes were demonstrated within the lesion with electron microscopy. With immunohistochemistry neurons were positive for neuron specific enolase (NSE) and S-100 and the Schwann cells and enteric glial cells were positive for S-100 and glial fibrillary acidic protein (GFAP). The pathogenesis of GN is poorly understood. GN, although rare, should be included in the differential diagnosis of gastrointestinal tumors in the horse.

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Colonic Ganglioneuromatosis in a Steer

Cited by 14 publications

References 5 publications

Small intestinal ganglioneuromatosis in a dog

Small intestinal ganglioneuromatosis in a dog

A malignant and metastasizing feline cardiac ganglioneuroma

Colonic Ganglioneuromatosis in a Horse

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