Colonic Injuries Induced by Inhalational Exposure to Particulate‐Matter Air Pollution

Li, Xiaobo; Cui, Jian; Yang, Hongbao; Sun, Hao; Lu, Runze; Gao, Na; Meng, Qingtao; Wu, Shenshen; Wu, Jiong; Aschner, Michael; Chen, Rui

doi:10.1002/advs.201900180

Cited by 30 publications

(28 citation statements)

References 37 publications

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“…Furthermore, it is essential to study the nano-and microplastics that cross the intestinal barrier; even small quantities of translocated plastic may be as dangerous as or even more dangerous than plastics excreted in the stools. Lastly, in view of the recent literature on the effects of particulate matter in the atmosphere, the impact of airborne microplastics on the intestine should also be assessed [135][136][137].…”

Section: Discussionmentioning

confidence: 99%

Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature

2020

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Background Together with poor biodegradability and insufficient recycling, the massive production and use of plastics have led to widespread environmental contamination by nano- and microplastics. These particles accumulate across ecosystems - even in the most remote habitats - and are transferred through food chains, leading to inevitable human ingestion, that adds to the highest one due to food processes and packaging. Objective The present review aimed at providing a comprehensive overview of current knowledge regarding the effects of nano- and microplastics on intestinal homeostasis. Methods We conducted a literature search focused on the in vivo effects of nano- and microplastics on gut epithelium and microbiota, as well as on immune response. Results Numerous animal studies have shown that exposure to nano- and microplastics leads to impairments in oxidative and inflammatory intestinal balance, and disruption of the gut’s epithelial permeability. Other notable effects of nano- and microplastic exposure include dysbiosis (changes in the gut microbiota) and immune cell toxicity. Moreover, microplastics contain additives, adsorb contaminants, and may promote the growth of bacterial pathogens on their surfaces: they are potential carriers of intestinal toxicants and pathogens that can potentially lead to further adverse effects. Conclusion Despite the scarcity of reports directly relevant to human, this review brings together a growing body of evidence showing that nano- and microplastic exposure disturbs the gut microbiota and critical intestinal functions. Such effects may promote the development of chronic immune disorders. Further investigation of this threat to human health is warranted.

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Section: Discussionmentioning

confidence: 99%

Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature

2020

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“…In addition to inhalation, particles and microorganisms released by industrial waste and vehicle exhaust can contaminate food and water supplies, thereby suggesting another route of oral/gastrointestinal exposure ( 109 , 110 ). Recent epidemiological studies have shown a direct link between particulate matter exposure and intestinal defects ( 111 ). Inflammation is a normative response to environmental stressors, even being important for wound healing ( 111 ).…”

Section: Introductionmentioning

confidence: 99%

“…Recent epidemiological studies have shown a direct link between particulate matter exposure and intestinal defects ( 111 ). Inflammation is a normative response to environmental stressors, even being important for wound healing ( 111 ). Commensal gut bacteria modulate the production of reactive oxygen species and various growth factors responsible for intestinal epithelial migration and proliferation ( 112 ).…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, dysbiosis of the gut microbiome induced by harmful pollutants ( 113 ) may severely impair critical processes necessary for intestinal epithelial wound healing ( 114 – 116 ). However, the protective or detrimental role of PM-induced inflammation on gut epithelial cells continues to be an active area of investigation ( 111 ). Chronic PM exposure for 12 mo in mice resulted in epithelial lesions and the confluence of inflammatory cells in murine colons ( 111 ).…”

Section: Introductionmentioning

confidence: 99%

“…However, the protective or detrimental role of PM-induced inflammation on gut epithelial cells continues to be an active area of investigation ( 111 ). Chronic PM exposure for 12 mo in mice resulted in epithelial lesions and the confluence of inflammatory cells in murine colons ( 111 ). In addition, normal human colon epithelial cells (NCM460) exposed to PM for 48–72 h showed an increased expression of fibroblast growth factor receptor 4 ( FGFR4 ) ( 111 ), which is associated with the development of colon cancer ( 117 ).…”

Section: Introductionmentioning

confidence: 99%

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Every breath you take: Impacts of environmental dust exposure on intestinal barrier function–from the gut-lung axis to COVID-19

Crawford

Nordgren

McCole

2021

American Journal of Physiology-Gastrointestinal and Liver Physi

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As countries continue to industrialize, major cities experience diminished air quality, while rural populations also experience poor air quality from sources such as agricultural operations. These exposures to environmental pollution from both rural and populated/industrialized sources have adverse effects on human health. Although respiratory diseases (e.g. asthma and chronic obstructive pulmonary disease) are the most commonly reported following long-term exposure to particulate matter and hazardous chemicals, gastrointestinal complications have also been associated with the increased risk of lung disease from inhalation of polluted air. The interconnectedness of these organ systems has offered valuable insights into the roles of the immune system and the micro/mycobiota as mediators of communication between the lung and the gut during disease states. A topical example of this relationship is provided by reports of multiple gastrointestinal symptoms in patients with coronavirus disease 2019 (COVID-19), while the rapid transmission and increased risk of COVID-19 has been linked to poor air quality and high levels of particulate matter. In this review, we focus on the mechanistic effects of environmental pollution on disease progression with special emphasis on the gut-lung axis.

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Oral Delivery of Transformable Bilirubin Self‐Assembled System for Targeted Therapy of Colitis

Chen,

Hao

et al. 2023

Adv Healthcare Materials

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Ulcerative colitis (UC) is a high incidence disease worldwide and clinically presents as relapsing and incurable inflammation of the colon. Bilirubin (BR), a natural antioxidant with significant anti‐colitic effects, is utilized in preclinical studies as an intestinal disease therapy. Due to their water‐insolubility, the design of BR‐based agents usually involves complicated chemosynthetic processes, introducing various uncertainties in BR development. After screening numerous materials, it is identified that chondroitin sulfate can efficiently mediate the construction of BR self‐assembled nanomedicine (BSNM) via intermolecular hydrogen bonds between dense sulfate and carboxyl of chondroitin sulfate and imino groups of BR. BSNM exhibits pH sensitivity and reactive oxygen species responsiveness, enabling targeted delivery to the colon. After oral administration, BSNM significantly inhibits colonic fibrosis and apoptosis of colon and goblet cells; it also reduces the expression of inflammatory cytokines. Moreover, BSNM maintains the normal level of zonula occludens‐1 and occludin to sustain the integrity of intestinal barrier, regulates the macrophage polarization from M1 to M2 type, and promotes the ecological recovery of intestinal flora. Collectively, the work provides a colon‐targeted and transformable BSNM that is simple to prepare and is useful as an efficient targeted UC therapy.

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Colonic Injuries Induced by Inhalational Exposure to Particulate‐Matter Air Pollution

Cited by 30 publications

References 37 publications

Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature

Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature

Every breath you take: Impacts of environmental dust exposure on intestinal barrier function–from the gut-lung axis to COVID-19

Oral Delivery of Transformable Bilirubin Self‐Assembled System for Targeted Therapy of Colitis

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