2015
DOI: 10.1128/jcm.00579-15
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Colonization with Escherichia coli Strains among Female Sex Partners of Men with Febrile Urinary Tract Infection

Abstract: fOf 23 unique Escherichia coli strains from 10 men with febrile urinary tract infections (UTIs) and their female sex partners, 6 strains (all UTI causing) were shared between partners. Molecularly, the 6 shared strains appeared more virulent than the 17 nonshared strains, being associated with phylogenetic group B2, sequence types ST73 and ST127, and multiple specific virulence genes. This indicates that UTIs are sometimes sexually transmitted. Escherichia coli is the leading cause of urinary tract infection (… Show more

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Cited by 18 publications
(21 citation statements)
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“…Another similar study defined only the presence of ST131, which as B2 isolates, were predominant in pyelonephritis (75%) and cystitis (68%), but scanter among fecal isolates (34%) among E. coli isolates from previously healthy men (Kudinha et al 2013). Finally, in another study of note, shared strains in a cohort of couples of men with febrile community-acquired UTI and their female sexual partners (Ulleryd et al 2015) were more likely to belong to MLST clonal complexes (CC)73 and CC127, and carried several virulence genes (Ulleryd et al 2015). Thus, the specific virulence traits of clones affecting men are poorly described.…”
Section: Introductionmentioning
confidence: 99%
“…Another similar study defined only the presence of ST131, which as B2 isolates, were predominant in pyelonephritis (75%) and cystitis (68%), but scanter among fecal isolates (34%) among E. coli isolates from previously healthy men (Kudinha et al 2013). Finally, in another study of note, shared strains in a cohort of couples of men with febrile community-acquired UTI and their female sexual partners (Ulleryd et al 2015) were more likely to belong to MLST clonal complexes (CC)73 and CC127, and carried several virulence genes (Ulleryd et al 2015). Thus, the specific virulence traits of clones affecting men are poorly described.…”
Section: Introductionmentioning
confidence: 99%
“…One possibility, host-to-host transmission, is supported by evidence showing colonization of multiple household members with putatively the same ExPEC strain, with sporadic infection episodes occurring in colonized individuals [ 12 , 13 ]. This suggests that household transmission may precede the classic fecal-urethral pathway of urinary tract infection (UTI) pathogenesis, in which the immediate reservoir for an infecting ExPEC strain is the host's own intestinal and genital microbiota [ 14 16 ].…”
mentioning
confidence: 99%
“…UPEC strains can be transmitted via water, food [ 25 ], or through person-to-person contact [ 5 , 27 , 28 ]. However, the water supply in Takikawa is monitored strictly according to the Drinking Water Quality Standards of Japan, which includes ‘ E. coli , not to be detected.’ Although previous studies [ 29 , 30 ] reinforced within-household transmission, the absence of geographical case concentration suggested that acute UTIs less frequently occurred in women living together with the patients than expected.…”
Section: Discussionmentioning
confidence: 99%
“…In contrast, epidemics of nosocomial UTIs are recognised to be due to UPEC strains and these clusters of infections occasionally present unusual phenotypes with antimicrobial resistance [ 4 ]. In community settings, UPEC can be sexually transmitted [ 5 ] and may also be shared among household members in the absence of sexual contact [ 6 ]. Moreover, community-wide occurrence and outbreaks of UTIs caused by genetically closely related lineages of drug-resistant UPEC strains are reported [ 7 ].…”
Section: Introductionmentioning
confidence: 99%