Colonoscopy Findings in Patients Who Have Positive Fecal Occult Blood Test for Colorectal Cancer Screening

Mayır, Burhan; Ensari, Cemal Özben; Durhan, Abdullah; Çöpelci, Yaşar

doi:10.4274/tjcd.48403

Cited by 6 publications

(4 citation statements)

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“…In other similar studies, 75.7% of patients tested positive for FOBT were reported normal with colonoscopy, which was much higher than in our study 12,15,17 . In other studies similar to our findings, even pathological lesions were not detected in people with FOBT positive 18,19 . In our study, at least one lesion was detected in 78.5% of the patients in the colonoscopy performed on FOBT positive patients.…”

Section: Discussionsupporting

confidence: 92%

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How Effective is a Fecal Occult Blood Test to Detect Malignancy?

ŞAHİN¹,

Güzel²,

METE³

2022

NKTD

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Aim: Cancer, an important public global health problem, is the second leading cause of death after cardiovascular diseases. We aimed to reveal the incidence of colorectal cancer (CRC) by the positive fecal occult blood test (FOBT), requested within the scope of periodic health examination (PHE) in patients applied to the family medicine outpatient clinic. Materials and Methods:A total of 119 people aged between 50 and 70 years, who applied to the family medicine outpatient clinic of a university hospital for general health check-up, were included in the study. A questionnaire, in which socio-demographic data and CRC risk factors were questioned, was applied to the participants. The hemogram, FOBT, colonoscopy, and the pathology results of the patients were evaluated.Results: Of 119 participants, 62 (52.1%) were female and 57 (47.9%) were male. The mean age of the participants was 61.0±7.6 years. FOBT was found to be positive in 65 (54.6%) of all participants. Five people (4.2%) who participated in the study were diagnosed with CRC according to the biopsy results obtained during the colonoscopy procedure. In our study, the rate of malignancy detection in all patients with positive FOBT including CRC diagnosis was found to be 7.7% (n=5). Our study detected statistically significant relationships between FOBT positivity and diagnosis of CRC. Conclusion:Following the appropriate recommendations of PHE guidelines and CRC screenings in individuals with high-risk levels, FOBT contributes to early diagnosis and referral to treatment as soon as possible.

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Section: Discussionsupporting

confidence: 92%

“…reported a 7.1% CRC detection rate in their series of 53,332 cases of FOBT positivity in the screening group, and our findings were similar to several similar studies 12,18 . There are also studies with a lower rate of CRC compared to our study 15,16,19 .…”

Section: Discussionsupporting

confidence: 38%

How Effective is a Fecal Occult Blood Test to Detect Malignancy?

ŞAHİN¹,

Güzel²,

METE³

2022

NKTD

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“…Mayir ve ark. (8) tarama bireylerinden oluşan 127 olguluk serilerinde, %37 normal kolonoskopik bulgular, ikisi malign polip ve hafif displazi içeren %31.5 polipektomi, %18.9 divertiküler hastalık, %31.5 BAH bulduklarını ve herhangi bir maligniteye rastlamadıklarını rapor etmişlerdir. Quyn AJ ve ark.…”

Section: Discussionunclassified

Evaluation Of The Effectiveness Of Colon Cancer Screening Program Conducted in Our Region

Kara¹,

Sarıcı²,

Kalaycı³

2018

İKSST

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ÖZAmaç: Kolon kanseri tarama programı (KKTP) kapsamında birinci basamaktan kliniğimize yönlendirilen herhangi bir yakınması olmayıp GGK pozitifliği saptanan ardışık 300 olguya yapılan kolonoskopi sonuçları ile Sağlık Bakanlığınca bölgemizde yürütülen KKTP'nin etkinliğini araştırmayı amaçladık. Yöntem: Çalışmaya alınan bireylerin demografik özellikleri, kolonoskopi bulguları, patolojik tanıları ve tedavi sonuçları retrospektif olarak incelendi. Bulgular: Olguların 180'i kadın (%60), idi. On iki hastada (%4) kolorektal kanser (KRK) belirlendi. Bir hastada geniş tabanlı, sesil polipte yüksek grade displazili, tübülovillöz adenom saptandı. Bu 13 hastaya erken evrede laparoskopik olarak onkolojik prensiplere uygun cerrahi uygulandı. Toplamda 120 olguya prekanseröz adenomatöz polipler nedeni ile polipektomi uygulandı; bunların 30'unda (%10) yüksek gradeli displazi (YGD) saptandı. Kırkiki olguda (%14) benign anorektal hastalıklar (BAH) (fissür, hemoroid vb.) saptandı. Yirmi yedi (% 9) olguda divertiküler hastalık belirlendi. Patoloji sonucu ile 9 olguya (%3) ülseratif kolit ve 19 olguya (%6.3) nonspesifik kolit tanısı konuldu. Seksensekiz olguda (%29.3) normal kolonoskopik bulgular rapor edildi. Sonuç: Asemptomatik safhada kolon kanseri saptanan oniki ve bir geniş tabanlı YGD'li sesil polipli, olguya erken evrede cerrahi uygulanmıştır. Yüz yirmi olguda prekanseröz adenomatöz poliplere, polipektomi uygulanmış ve kolonoskopik takibe alınmıştır. Türkiyede KKTP'nin yaygınlaştırılması, etkin uygulanması ile erken teşhis ve tedavi oranlarının artacağı aynı zamanda KRK mortalite ve morbiditesinde önemli azalma olabileceği düşüncesindeyiz.Anahtar kelimeler: kolorektal kanser tarama programı, gaitada gizli kan, tarama kolonoskopisi, kolon polibi ABSTRACT Introduction: In order to search the success and efficacy of Colon Cancer Screening Program (CCSP), we aimed to evaluate the colonoscopic results of FOBT-positive 300 consecutive individuals that have been refered to our clinic within the scope of screening program. Method: Demographic features, colonoscopic findings, pathologic results, final diagnosis and treatment results of individuals were examined retrospectively. Results: A hundred and eighty (60%) individuals were women and 120 (40%) individuals were men. The median age of the individuals was 56 (50-70) years. Colorectal carcinoma (CRC) was detected in 12 (4%) patients. İn one patient tubulovillous adenoma with high grade dysplasia (HGD) was detected in broad-based sessile polyp. Laparoscopic surgery in compliance with oncologic principles was performed in these thirteen patients during the early stage of the disease. Precancerous adenomatous polyps were detected in 120 (40%), and high grade dysplasia (HGD) in 30 (10%) patients. In 42 individuals, benign anorectal diseases (fissure, hemorrhoids) were detected. Twenty-seven (9%) individuals had diverticulosis. According to pathologic results, nine (3%) patients were diagnosed as ulcerative colitis and nineteen (6.3%) patients as nonspecific colitis. Eighty-eight individua...

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“…21 In Turkey, colorectal cancer is the third most commonly diagnosed cancer in both men (9.3%) and women (8.3%). 22…”

Section: Discussionmentioning

confidence: 99%

Mid-transverse Location in Primary Colon Tumor: A Poor Prognostic Factor?

Zenger

Gürbüz

Can

et al. 2022

Diseases of the Colon &Amp; Rectum

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BACKGROUND: The location of colonic tumors has been linked to different clinical and oncologic outcomes. Transverse colon cancers are generally included as right colon cancers. Furthermore, hepatic and splenic flexure tumors are usually included as components of the transverse colon. OBJECTIVE: This study was aimed at comparing the clinicopathologic characteristics and long-term outcomes between mid-transverse and right and left colon cancers and determining the prognostic impact of the primary tumor location in the mid-transverse colon. DESIGN: This was a retrospective study. SETTINGS: Two specialized colorectal centers were included. PATIENTS: Patients who underwent curative surgery for colon cancer were analyzed. Tumors located in the transverse colon, excluding the flexures, were defined as mid-transverse colon cancers. MAIN OUTCOME MEASURES: Demographic characteristics, operative outcomes, pathologic results, and long-term outcomes were the primary outcome measures. RESULTS: Of the 487 patients, 41 (8.4%) had mid-transverse, 191 (39.2%) had right, and 255 (52.4%) had left colon cancers. For mid-transverse colon cancers, the mean length of hospital stay, mean length of the resected specimen, and the mean number of harvested lymph nodes were significantly higher. For patients with stage I to III cancer, the 5-year overall and disease-free survival rates were significantly worse in the mid-transverse colon cancers than in the right and left colon cancers (overall survival: 55.5% vs 82.8% vs 85.9%, p = 0.004, and disease-free survival; 47.7% vs 72.4% vs 79.5%, p = 0.003). After adjustment for other clinicopathologic factors, mid-transverse colon cancers were significantly associated with a poor prognosis (HR = 2.19 [95% CI, 1.25–3.83]; p = 0.006). LIMITATIONS: Molecular and genetic information were unavailable in this retrospective study. CONCLUSIONS: In our case series, colon cancers located in the mid-transverse colon showed poorer prognosis than cancers in other locations. The impact of tumor location in the mid-transverse colon on prognosis, including molecular and genetic markers, should be investigated further in prospective studies. See Video Abstract at http://links.lww.com/DCR/B631. LOCALIZACIÓN TRANSVERSA MEDIA EN EL TUMOR DE COLON PRIMARIO: ¿UN FACTOR DE MAL PRONÓSTICO? ANTECEDENTES: La ubicación de los tumores de colon se ha relacionado con diferentes resultados clínicos y oncológicos. Los cánceres de colon transverso se incluyen generalmente como cánceres de colon derecho. Además, los tumores del ángulo hepático y esplénico suelen incluirse como un componente del colon transverso. OBJETIVO: Este estudio tuvo como objetivo comparar las características clínico-patológicas y los resultados a largo plazo entre los cánceres de colon transverso medio y derecho e izquierdo y determinar el impacto pronóstico de la ubicación del tumor primario en el colon transverso medio. DISEÑO: Este fue un estudio retrospectivo. AJUSTE ENTORNO CLINICO: Se incluyeron dos centros colorrectales especializa...

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Colonoscopy Findings in Patients Who Have Positive Fecal Occult Blood Test for Colorectal Cancer Screening

Cited by 6 publications

References 6 publications

How Effective is a Fecal Occult Blood Test to Detect Malignancy?

How Effective is a Fecal Occult Blood Test to Detect Malignancy?

Evaluation Of The Effectiveness Of Colon Cancer Screening Program Conducted in Our Region

Mid-transverse Location in Primary Colon Tumor: A Poor Prognostic Factor?

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