Colorectal Adenocarcinoma in Crohn's Disease

Ribeiro, M B; Greenstein, Adrian J.; Sachar, David B.; Barth, Jay; Balasubramanian, Sankar; Harpaz, Noam; Heimann, Tomas M.; Aufses, Arthur H.

doi:10.1097/00000658-199602000-00011

Cited by 108 publications

(68 citation statements)

References 43 publications

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“…In this study, the duration between CD diagnosis and the occurrence of cancer in the patients with CRC and small bowel cancer was significantly longer than that in the patients with extraintestinal cancer (namely, a median of 21.5 vs. 12 years, respectively). The long duration between CD diagnosis and occurrence of CRC and small bowel cancer has been similarly reported in Western countries [6,7,28,29]. These results seem to indicate the impact of refractory intestinal inflammation on carcinogenesis.…”

Section: Discussionsupporting

confidence: 67%

“…These results seem to indicate the impact of refractory intestinal inflammation on carcinogenesis. The age at cancer diagnosis in patients with CRC and small bowel cancer was 52 years according to studies reported in Western countries [6,7,28,29], and therefore it was not significantly different from that in patients presenting with extraintestinal cancer.…”

Section: Discussionmentioning

confidence: 90%

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Malignancy in Crohn’s Disease: Incidence and Clinical Characteristics in Japan

Mizushima¹,

Ohno²,

Nakajima³

et al. 2010

Digestion

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Background/Aims: This study investigated the occurrence of malignancies in Japanese patients with Crohn’s disease (CD) and compared the incidence with that in the general population. Methods: The medical records of 294 CD patients, treated between 1989 and 2009, were reviewed and the prevalence of malignancies was assessed. Registration of person-years at risk was calculated individually, from the year of CD diagnosis until the year of cancer diagnosis, death or end of follow-up. The observed number of cancer cases was compared with the expected number, calculated on the basis of the individually computed person-years at risk and the corresponding age- and sex-specific incidence rates in the background population. Results: Thirteen cancers developed in 12 patients among a total of 4,248 person-years available for analysis. There were six CRCs, two gastric cancers, two uterine cancers, one small bowel cancer, one biliary cancer, and one cancer of unknown primary site. The risk of cancer (all sites) was significantly increased from that of the background population; SIR 2.24 (95% CI 1.19–3.83). In particular, the risk of CRC significantly increased in comparison to that of the background population; SIR 5.80 (95% CI 2.13–12.68). Conclusions: Japanese patients with CD are at increased risk of cancer, particularly CRC.

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Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 90%

Malignancy in Crohn’s Disease: Incidence and Clinical Characteristics in Japan

Mizushima¹,

Ohno²,

Nakajima³

et al. 2010

Digestion

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“…1) We have found that CRC in IC, as in UC 15,21 and CD, 16,22 3) Our study also supports previous findings in UC 24,25 that IC-associated CRC usually occurs in the distal colon, since 53% of the patients (8 of 15) had a tumor occurring in the rectosigmoid area and 73% had malignances distal to the transverse colon. This predilection for the distal colon was noted even though 12 of our 15 patients had disease extending proximal to splenic flexure, and in 10 cases the disease extended even proximally to hepatic flexure.…”

Section: Discussionsupporting

confidence: 87%

Colorectal carcinoma in indeterminate colitis

Branco

Harpaz

Sachar

et al. 2009

Inflammatory Bowel Diseases

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“…In 2 of them the diagnosis of concurrently existing carcinoma of the large bowel and Crohn’s disease was suspected at the operation table and was confirmed histologically by the operative specimen. It seems that the incidence, characteristics and prognosis of colorectal carcinoma complicating Crohn’s disease are similar to the features of cancer complicating ulcerative colitis including young age and long duration of disease [42, 43]. Review of the literature indicated that 191 of the 295 cases (64.8%) of colorectal carcinomas in Crohn’s disease reported so far occurred in the past 7 years [44].…”

Section: Discussionmentioning

confidence: 99%

Clinical Patterns of Crohn’s Disease in Greece: A Follow-Up Study of 155 Cases

Triantafillidis

Emmanouilidis²,

Manousos³

et al. 2000

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The aim of this prospective study was to elucidate the clinical features and natural history of Crohn’s disease in Greece. One hundred and fifty-five Greek patients with definite diagnosis of Crohn’s disease were followed-up for a mean period of 9.7 years and evaluated for clinical patterns and course of illness. The male/female ratio was 1.58:1. The peak incidence of the disease was observed between 20 and 30 years of age. The majority of patients were urban dwellers and of higher socio-economic level compared to the general population of Greece. In almost 50% of the patients symptoms of the disease started below the age of 30, although in almost one in every 5 cases, symptoms appeared after the age of 50. Familial clustering of inflammatory bowel disease was observed in 1.3%. The pattern of anatomic involvement was: ileocolic 33.3%, colon 33.3% and small bowel 33.3%. The kind of predominant symptoms at the time of diagnosis was related to the anatomic location of the disease. At least one extraintestinal manifestation appeared in 42% of patients. Perianal disease was noticed in 21.3% with fistulae and abscesses being the most common manifestation. Fifty-one percent of patients were operated upon at least once during the follow-up period because of acute abdomen, bad response to conservative treatment and fistulae and abscesses. Emergency operation was required in 17.3% of the patients. Evolution to cancer was observed in 3 patients (2%). During the follow-up period of 9.7 ± 6.5 years, 18 patients (11.6%) died. A considerable mortality was noticed in the surgically treated group of patients, while in the nonoperated group the disease was running with milder symptoms. It is concluded that some of the clinicoepidemiological characteristics of patients with Crohn’s disease in Greece are in accordance with those reported from western as well as the neighboring Mediterranean countries. However, other parameters such as the higher incidence of the disease in males, the low incidence of familial clustering, and the low incidence of perianal disease, underline the importance of environmental, genetic and other factors on the evolution and behavior of the disease in different parts of the world.

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Colorectal Adenocarcinoma in Crohn's Disease

Cited by 108 publications

References 43 publications

Malignancy in Crohn’s Disease: Incidence and Clinical Characteristics in Japan

Malignancy in Crohn’s Disease: Incidence and Clinical Characteristics in Japan

Colorectal carcinoma in indeterminate colitis

Clinical Patterns of Crohn’s Disease in Greece: A Follow-Up Study of 155 Cases

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