Colorectal cancer and atrial fibrillation: a case-control study

Guzzetti, Stefano; Costantino, Giorgio; Sada, Simona; Fundarò, Camilla

doi:10.1016/s0002-9343(02)01029-x

Cited by 47 publications

(45 citation statements)

References 10 publications

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“…2). These data confirm the results of our preliminary case-control study, in which, an increased prevalence of AF in colorectal cancer was found [13]. Moreover, the current study underlines that the relation between AF and cancer is not restricted to particular cancer localization.…”

Section: Discussionsupporting

confidence: 92%

First diagnosis of colorectal or breast cancer and prevalence of atrial fibrillation

et al. 2008

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Aim of the present study was to assess the prevalence of atrial fibrillation (AF) in patients with two different types of cancer. Recent epidemiologic and clinical studies support the hypothesis that AF is promoted and maintained by a broad spectrum of modulating factors. A total of 2,339 patients admitted to the Surgery Department of "Luigi Sacco Hospital, Milan," over the period 1987-2004 were eligible for the study. One thousand three hundred and seventeen patients were admitted consecutively with a first diagnosis of colorectal or breast cancer (cases). The remaining 1,022 were patients admitted to undergo non-neoplastic surgery (controls). Routine pre-surgery electrocardiogram available in patient charts was analysed by a cardiologist who was not aware of the present study to evaluate the presence of atrial fibrillation or other arrhythmias. Overall, AF was present in 3.6% cases and 1.6% controls. This corresponded to at least two times higher likelihood of having AF in cases compared to controls. Prevalence of AF increased with age both in cases and controls. Our study describes an increased prevalence of AF in two different types of cancer. Autonomic, endocrine, coagulation, and inflammatory alterations were previously described in both AF and cancer, and can provide the physiopathological basis to our clinical observation.

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Section: Discussionsupporting

confidence: 92%

First diagnosis of colorectal or breast cancer and prevalence of atrial fibrillation

et al. 2008

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“…In a recent study performed among patients admitted to a surgical department, patients with first diagnosis of colorectal cancer had an approximately threefold higher risk for AF compared with a control group admitted for non-neoplastic diseases (odds ratio [OR] 3.5, 95% confidence interval [CI] 1.6-7.2) [11]. Inflammation plays an important role in carcinogenesis [12] and could provide a possible explanation for a relation between AF and cancer.…”

Section: Cancermentioning

confidence: 99%

Atrial fibrillation in chronic non-cardiac disease: Where do we stand?

Lainščak¹,

Dagres²,

Filippatos³

et al. 2008

International Journal of Cardiology

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“…The effect of chemotherapy on the heart is often magnified by the comorbid cardiovascular risk factors of an aging population. Direct cardiotoxicity of neoplasms is also poorly understood and further confounds the investigation into the effect of these agents [3]. Therefore, this population is vulnerable to any toxicity that affects vascular, myocyte, or electrophysiological function [4].…”

Section: Introductionmentioning

confidence: 99%

“…While the effect of these agents upon the left ventricular pump function is increasingly understood at a mechanistic and therapeutic level, the risk of arrhythmia related to antineoplastic agents remains poorly characterized. Despite arrhythmias being frequently reported as complications, they are rarely studied in further detail, and cancer may itself promote arrhythmia development [3]. In this review, we describe the range of arrhythmias that can be induced by common antineoplastic agents and evaluate what is known about the underlying mechanisms (table 1).…”

Section: Introductionmentioning

confidence: 99%

Arrhythmia and Electrophysiological Effects of Chemotherapy: A Review

Markman

Nazarian²

2016

Oncology

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Importance: Cardiotoxicity is an important limiting factor in the use of antineoplastic agents. The risk of arrhythmia and the electrophysiological effects of these agents are poorly characterized though increasing evidence suggests a high prevalence of complications. Observations: Patients with substantial cardiovascular risk factors are often excluded from clinical trials, while the aging population of patients actually receiving therapies may have an underlying arrhythmogenic substrate due to comorbidities. Risk stratification of patients before the selection of a therapeutic regimen is essential. Given the regular use of combination therapies, the potential for arrhythmia of each agent must be fully understood. Despite limited data and understanding in clinical practice, decisions on whether to initiate specific therapies in high-risk patients and how to manage the associated complications are made regularly. Conclusions and Relevance: This review describes the observed arrhythmias and proposed mechanisms for several major classes of antineoplastic agents. It also provides recommendations for risk stratification, monitoring, prophylaxis, and therapy, emphasizing the need for a collaborative relationship between oncologists and cardiologists and areas for future research.

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Colorectal cancer and atrial fibrillation: a case-control study

Cited by 47 publications

References 10 publications

First diagnosis of colorectal or breast cancer and prevalence of atrial fibrillation

First diagnosis of colorectal or breast cancer and prevalence of atrial fibrillation

Atrial fibrillation in chronic non-cardiac disease: Where do we stand?

Arrhythmia and Electrophysiological Effects of Chemotherapy: A Review

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