Colorectal Cancer and Inflammatory Bowel Disease

Abstract

Inflammatory bowel disease I"D with its two entities, ulcerative colitis and Crohn's disease, is at increased risk of developing colorectal cancer CRC . Risk factors for CRC are represented by the duration of the disease, extent of disease, the association of primary sclerosing cholangitis, family history, and early age at onset. In inflammatory bowel disease, colonic carcinogenesis appears on an inflamed colon, being determined by different genetic alterations. The main element of the process of carcinogenesis is the dysplasia, which is a neoplastic intraepithelial transformation, limited to the basal membrane surrounding the glands around which it appears. The stages of carcinogenesis process start with dysplasia of varying degrees as follows indefinite dysplasia, low-grade dysplasia, high-grade dysplasia, and finally invasive adenocarcinoma.

Natural Coumarins: Exploring the Pharmacological Complexity and Underlying Molecular Mechanisms

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A Literature‐Based Update on Benincasa hispida (Thunb.) Cogn.: Traditional Uses, Nutraceutical, and Phytopharmacological Profiles

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