Colorectal Cancer in Iran: Molecular Epidemiology and Screening Strategies

Dolatkhah, Roya; Bonyadi, Mortaza; Kermani, Iraj Asvadi; Farassati, Faris; Dastgiri, Saeed

doi:10.1155/2015/643020

Cited by 86 publications

(58 citation statements)

References 50 publications

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“…So, age-standardized CRC incidence rate, during 2008, among males and females in Western European population have been 41.2 and 26.3, and in Western Asian populations 13.1 and 10.1, respectively (Jemal et al, 2011). Apparently, the incidence rate of CRC, particularly in early-onset group, is similar in both male and female among our population according to our results and some similar studies (Kolahdoozan et al, 2010;Dolatkhah et al, 2015).…”

Section: 4647 Epidemioclinical Features Of Early-onset Colorectal Casupporting

confidence: 85%

“…This is near to other previous studies in Iran (Fatemi et al, 2010;Dolatkhah et al, 2015). We considered for FCC families, existence of at least three affected members among the first or second degree relatives.…”

Section: 4647 Epidemioclinical Features Of Early-onset Colorectal Camentioning

confidence: 67%

“…Accordingly, the frequency rate of FCC among the early-onset probands in our study was calculated 24.2%, most of which fulfilled the Amsterdam II Criteria and were reproduced as HNPCC families (20.5%). It is more than previous studies in the Province and other parts of Iran (Yuen et al, 2002;Ansari et al, 2006;Fatemi et al, 2010;Nemati et al, 2011;Dolatkhah et al, 2015). Since the proportion of early-onset probands to all CRC patients has been calculated nearly 25%, the total frequency of HNPCC families according to Amsterdam II Criteria is estimated 0.25×20.5% = 5.1%.…”

Section: 4647 Epidemioclinical Features Of Early-onset Colorectal Camentioning

confidence: 82%

“…This study among other Eastern studies has shown that Early-onset CRC (less than 50 years of age at diagnosis) covers almost one fourth of all CRC cases in the country. This is different from Western countries where the rates of early-onset CRC include less than 10% of all CRC cases (Griffin et al, 1991;Mitry et al, 2001;Yuen et al, 2002;Claes et al, 2005;Yazdizadeh et al, 2005;Ansari et al, 2006;Dolatkhah et al, 2015). Given the changing of life style in developing societies like Iran toward westernization, in particular within youth, incident rate of early-onset CRC has been increased in these populations during the recent decades (Fatemi et al, 2010;Safari et al, 2013;Dolatkhah et al, 2015).…”

Section: 4647 Epidemioclinical Features Of Early-onset Colorectal Camentioning

confidence: 99%

“…Its incidence has been increased during the last 3 decades more than 80% according to recent studies (Yazdizadeh et al, 2005;Dolatkhah et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Epidemioclinical Feature of Early-Onset Colorectal Cancer at-Risk for Lynch Syndrome in Central Iran

Zeinalian

Chaleshtori²,

Akbarpour³

2015

Asian Pacific Journal of Cancer Prevention

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Section: 4647 Epidemioclinical Features Of Early-onset Colorectal Casupporting

confidence: 85%

Section: 4647 Epidemioclinical Features Of Early-onset Colorectal Camentioning

confidence: 67%

Section: 4647 Epidemioclinical Features Of Early-onset Colorectal Camentioning

confidence: 82%

Section: 4647 Epidemioclinical Features Of Early-onset Colorectal Camentioning

confidence: 99%

“…Its incidence has been increased during the last 3 decades more than 80% according to recent studies (Yazdizadeh et al, 2005;Dolatkhah et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Epidemioclinical Feature of Early-Onset Colorectal Cancer at-Risk for Lynch Syndrome in Central Iran

Zeinalian

Chaleshtori²,

Akbarpour³

2015

Asian Pacific Journal of Cancer Prevention

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Rare single‐nucleotide variants of MLH1 and MSH2 genes in patients with Lynch syndrome

Mirabdolhosseini,

Yaghoob Taleghani,

Rejali

et al. 2023

Cancer Reports

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BackgroundApproximately 5% of colorectal cancers (CRCs) are hereditary. Lynch syndrome (LS), also known as hereditary nonpolyposis colorectal cancer (HNPCC), is the most common form of recognized hereditary CRC. Although Iran, as a developing country, has a high incidence of CRC, the spectrum of variants has yet to be thoroughly investigated.AimsThis study aimed to investigate pathogenic and non‐pathogenic variants in MLH1 and MSH2 genes in Iranian patients with suspected Lynch syndrome (sLS).Methods and resultsIn the present study, 25 peripheral blood samples were collected from patients with sLS and high microsatellite instability (MSI‐H). After DNA extraction, all samples underwent polymerase chain reaction and Sanger sequencing to identify the variants in the exons of MLH1 and MSH2 genes. The identified variants were interpreted using prediction tools, and were finally reported under ACMG guidelines. In our study population, 13 variants were found in the MLH1 gene and 8 in the MSH2 gene. Interestingly, 7 of the 13 MLH1 variants and 3 of the 8 MSH2 variants were novel, whereas the remaining variants were previously reported or available in databases. In addition, some patients with sLS did not have variants in the exons of the MLH1 and MSH2 genes. The variants detected in the MLH1 and MSH2 genes had specific characteristics regarding the number, area of occurrence, and their relationship with demographic and clinicopathologic features.ConclusionOverall, our results suggest that analysis of MLH1 and MSH2 genes alone is insufficient in the Iranian population, and more comprehensive tests are recommended for detecting LS.

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Colorectal cancer literacy and related factors in northeast of Iran: A cross‐sectional study

Delshad,

Pourhaji,

Abdollahi

et al. 2024

Cancer Reports

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BackgroundColorectal cancer (CRC) is a health challenge and the second most common cancer worldwide. Increasing colorectal cancer literacy (CRCL) is one of the most effective factors in CRC prevention.AimThe aim of this study was to determine and evaluate CRCL and its related factors in Torbat Heydarieh, northeastern Iran.Methods and ResultsThis study was a cross‐sectional survey conducted in 2021 in Torbat Heydarieh, a city in northeastern Iran, on 200 clients presenting to a comprehensive health service centers.In addition to collecting sociodemographic characteristics, participants were administered the Knowledge and Attitude Questionnaire and the Colorectal Cancer Literacy Questionnaire (CRCLQ).Data were analyzed with SPSS software version 25 using independent samples t‐tests, one‐way analysis, chi‐square, and Pearson correlation coefficients. The statistical significance level was set at p < .05. The results showed that the mean age of the participants was 51.12 ± 8.45 years. The majority of participants (84%) stated that their friends and relatives had no history of CRC.Pearson correlation coefficient results showed a significant correlation between knowledge and attitude toward CRC (r = .15, p = .041). A significant correlation was also found between knowledge and CRCL (r = .4, p ≤ .001).ConclusionWe found low CRCL among clients of comprehensive health service centers. More targeted educational interventions are needed to promote CRCL among Iranian adults.

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Colorectal Cancer in Iran: Molecular Epidemiology and Screening Strategies

Cited by 86 publications

References 50 publications

Epidemioclinical Feature of Early-Onset Colorectal Cancer at-Risk for Lynch Syndrome in Central Iran

Epidemioclinical Feature of Early-Onset Colorectal Cancer at-Risk for Lynch Syndrome in Central Iran

Rare single‐nucleotide variants of MLH1 and MSH2 genes in patients with Lynch syndrome

Colorectal cancer literacy and related factors in northeast of Iran: A cross‐sectional study

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