Colorectal cancer in Rochester, Minnesota 1940–1969

Abstract

All residents of Rochester, Minn., with a diagnosis of cancer of the colon or rectum during the 30‐year period, 1940 through 1969, were identified from the records of the Mayo Clinic and the other resources in the Rochester epidemiologic central file. The medical records and microscopic slides on these patients were reviewed, and 439 met the necessary residency and diagnostic criteria. Adjusted average annual incidence rates per 100,000 for the entire time period for cancer of the colon were 33.0 for males and 24.6 for females and for rectal cancer, 16.3 for males and 13.7 for females. Age‐specific incidence rates increase progressively with age for cancer in both sites. Age‐adjusted rates for both colon and rectal cancer were consistently higher for males than for females in the three decades studied. However, for both sites, the male predominance appeared only in those patients more than 60 years of age. In this study, we were unable to demonstrate significant increases in incidence rates in either sex for cancer of the colon or rectum over the 30‐year period.

Anatomical Distribution of Colorectal Carcinoma in Iran: A Retrospective 15-yr Study to Evaluate Rightward Shift

“…Studies of Crerand et al (1991) evaluating the anatomical distribution of colorectal cancer in 1553 Irish patients over a 30 years period, Lanier et al (1973) over a 25 year period and Vobecky et al (1984) over 13 year period all showed a relatively stable rate of proximal lesions. Odigie et al (2009) studied the clinicopathologic characteristic of colorectal cancer in the Guinea Savannal region between 1981-2005, they found no shift in distribution subsite in (1981-1990) and (1991-2005).…”

“…Although left sided colon cancer are still more common, several studies were done about changes in anatomical distribution of this cancer in recent years. Proximal right ward shift was proven in some of these studies (Sariego et al, 1992;Cady et al, 1993;Nazarian et al, 1993;Cheng et al, 2001) and was not observed in others (Lanier et al, 1973;Vobecky et al, 1984;Crerand et al, 1991). Some believe that the rightward shift result from an absolute decrease in left sided cancer rather than true increase in incidence rate of right-sided colorectal cancer (Saltzstein et al, 1998;Cress et al, 2000;Rabeneck et al, 2003).…”

A novel hypothesis on the sensitivity of the fecal occult blood test

“…Approximately 34% to 58% of CRC patients present with rectal bleeding. [17][18][19][20] It is very plausible that occult bleeding precedes macroscopic bleeding and, thus, that sensitivity of FOBT depends on time to clinical diagnosis. Interestingly, the range of cancers that present with bleeding compares well with our sensitivity estimate of 51%.…”

Predictive factors by multivariate analysis for colorectal cancer in Malaysian patients undergoing colonoscopy

“…7 Rectal bleeding is one of the most common symptoms of colorectal cancer. 6,[8][9][10] However, rectal bleeding is commonly attributed to bleeding hemorrhoids in healthy populations. In one survey, 11 14% noticed seeing blood on the toilet paper and 2% seeing it in the toilet bowl over the preceding 6 months.…”