Colorectal Cancer: Prognostic Values

Abstract

After lung cancer colorectal cancer (Cc) is ranked the second, as a cause of cancer-related death. Th e purpose of this study was to analyze the Cc cases in our material with respect to all prognostic values including histological type and grade, vascular invasion, perineural invasion, and tumor border features. Th ere were investigated  cases of resection specimen with colorectal cancer, which were fi xed in buff ered neutral formalin and embedded in paraffi n. Tissue sections ((μm thick) were cut and stained with H&E. Adenocarcinoma was the most frequent histological type found in , of cases, in , of males and , of females; squamous cell carcinoma in ,, in , of males and , of females; mucinous carcinoma in ,, in , of males and , of females; while adenosquamous carcinoma, undiff erentiated carcinoma and carcinoma in situ in , of cases each. Dukes' classifi cation was used in order to defi ne the depth of invasion. Dukes B was found in , of cases, whereas in , of cases Dukes C was found. As far as histological grading is concerned, Cc was mostly with moderate diff erentiation (,) with neither vascular nor perineural invasion. Resection margins were in all cases free of tumor. Our data indicate that the pathologic features of the resection specimen constitute the most powerful predictors of postoperative outcome in Cc. Dukes' stage and degree of diff erentiation provide independent prognostic information in Cc. However, diff erentiation should be assessed by the worst pattern.

PD-L1 Expression in Colorectal Carcinoma: Immunohistochemical Study

“…Similar results have been seen with various researchers. 17,18,19 PD-L1 positivity was also more in rectal and sigmoid tumors with insignificant correlation. But Anna et al showed significant association of PD-L1 and TIL with right sided tumors.…”

Characteristics, Effect of Histological Grade and Localization on the Prognosis of Colorectal Cancer. A retrospective Study.

“…Suzana Manxhuka-Kerliu et al in their study found as Colorectal cancer in general was more frequent in men than in women 60,4% vs. 39,59%. [10] Albania has a lower incidence of colorectal cancer than neighboring countries with a rate of 9/100000 for males and 7.9/100000 for females and a mortality rate of 4.8/100000 and 4/100000, respectively.…”

“…1) Suzana Manxhuka-Kerliu et al in their study found as colorectal cancer in general was more frequent in men than in women 60,4% vs. 39,59%. [10] albania has a lower incidence of colorectal cancer than neighboring countries with a rate of 9/100000 for males and increases with age; the median age at diagnosis for colon cancer is 68 in and 72 in women; for rectal it is 63 years of age in both men and women. [16] as a result of rising crc incidence rates in younger age groups coincident with declining rates in older age groups, the proportion of cases diagnosed in individuals younger than age 50 increased from 6% in 1990 to 11% in 2013.…”

Profil Klinikopatologik Biopsi Massa Kolorektal di Instalasi Patologi Anatomi RSUD Arifin Achmad Provinsi Riau Periode Januari 2015 - Desember 2019

“…Penentuan jenis histopatologi massa kolorektal sangat penting untuk menentukan terapi dan prognosis. 23 Polip kolon memiliki prognosis baik dan dapat diterapi dengan eksisi lokal atau polipektomi sederhana. 1,3 Inflammatory Bowel Disease (IBD) seperti Crohn's Disease, kolitis ulseratif, dan kolitis kronik non spesifik dapat diterapi dengan menggunakan kortikosteroid, aminosalisilat, agen-agen imunosupresif seperti azathioprine, antibiotik seperti metronidazole, dan antibiotik spektrum luas dalam beberapa kasus.…”