“…A sensitivity analysis was conducted due to high heterogeneity. Four studies [ 26 , 27 , 30 , 35 ] were found to be mainly responsible for the heterogeneity, but their exclusion failed to reduce it consistently; an advantage for individuals with obesity and a history of BS was still highlighted (RR: 0.57, 95% CI: 0.47–0.69, p = 0.0001, I 2 = 75%).…”
Section: Resultsmentioning
confidence: 99%
“…From literature research we identified five studies [ 6 , 22 , 25 , 27 , 34 ] reporting the incidence of CRC only for men in the BS and in the non-surgical groups. A metanalysis showed a protective effect tendency against CRC for men with a history of BS, but this was not significant (RR: 0.74, 95% CI: 0.43–1.28, p = 0.2798, I 2 = 96%).…”
Section: Resultsmentioning
confidence: 99%
“…We found a significant (46%) reduction of risk of CRC (RR: 0.54, 95% CI: 0.37–0.79, p = 0.0014, I 2 = 90%) in women with a history of BS. Six studies [ 6 , 22 , 25 , 27 , 32 , 34 ] reported specific cancer incidence data for women.…”
Bariatric surgery has shown to be effective in producing sustained weight loss and the resolution of obesity related medical problems. Recent research focused on the role of obesity and adipose tissue in tumorigenesis, finding a strong crosslink through different mechanisms and highlighting an increase in cancer incidence in individuals with obesity. The aim of this meta-analysis is to find if bariatric surgery reduces the incidence of colorectal cancer in patients with obesity. We performed a meta-analysis including 18 studies (PROSPERO ID: CRD4202235931). Bariatric surgery was found to be significantly protective toward colorectal cancer incidence in individuals with obesity (HR: 0.81, p = 0.0142). The protective effect persisted when considering women (RR: 0.54, p = 0.0014) and men (RR: 0.74, p = 0.2798) separately, although this was not significant for the latter. No difference was found when comparing Roux-en-Y gastric bypass and sleeve gastrectomy. Bariatric surgery reduces the incidence of colorectal cancer in individuals with obesity independently from gender and surgical procedure. Prospective large cohort studies are needed to confirm these findings.
“…A sensitivity analysis was conducted due to high heterogeneity. Four studies [ 26 , 27 , 30 , 35 ] were found to be mainly responsible for the heterogeneity, but their exclusion failed to reduce it consistently; an advantage for individuals with obesity and a history of BS was still highlighted (RR: 0.57, 95% CI: 0.47–0.69, p = 0.0001, I 2 = 75%).…”
Section: Resultsmentioning
confidence: 99%
“…From literature research we identified five studies [ 6 , 22 , 25 , 27 , 34 ] reporting the incidence of CRC only for men in the BS and in the non-surgical groups. A metanalysis showed a protective effect tendency against CRC for men with a history of BS, but this was not significant (RR: 0.74, 95% CI: 0.43–1.28, p = 0.2798, I 2 = 96%).…”
Section: Resultsmentioning
confidence: 99%
“…We found a significant (46%) reduction of risk of CRC (RR: 0.54, 95% CI: 0.37–0.79, p = 0.0014, I 2 = 90%) in women with a history of BS. Six studies [ 6 , 22 , 25 , 27 , 32 , 34 ] reported specific cancer incidence data for women.…”
Bariatric surgery has shown to be effective in producing sustained weight loss and the resolution of obesity related medical problems. Recent research focused on the role of obesity and adipose tissue in tumorigenesis, finding a strong crosslink through different mechanisms and highlighting an increase in cancer incidence in individuals with obesity. The aim of this meta-analysis is to find if bariatric surgery reduces the incidence of colorectal cancer in patients with obesity. We performed a meta-analysis including 18 studies (PROSPERO ID: CRD4202235931). Bariatric surgery was found to be significantly protective toward colorectal cancer incidence in individuals with obesity (HR: 0.81, p = 0.0142). The protective effect persisted when considering women (RR: 0.54, p = 0.0014) and men (RR: 0.74, p = 0.2798) separately, although this was not significant for the latter. No difference was found when comparing Roux-en-Y gastric bypass and sleeve gastrectomy. Bariatric surgery reduces the incidence of colorectal cancer in individuals with obesity independently from gender and surgical procedure. Prospective large cohort studies are needed to confirm these findings.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.