Colorectal Cancers

Abstract

Colorectal cancers (CRCs) are malignancies with high incidence and mortality. Due to the introduction of screening programs leading to early diagnosis and treatment, a decrease in mortality from these cancers is being observed. However, therapeutic options for CRC, especially in advanced disease, are limited and require improvements. Development of targeted therapies based on the understanding of molecular alterations is a promising strategy. Our knowledge of the molecular environment that contributes to CRC is expanding. As research has progressed, we have come to realize that the protein biosynthesis pathway and its translational apparatus contribute significantly to cancer development and progression in Contents