Colorectal carcinomas: Diagnostic implications of their changing frequency and anatomic distribution

Ghahremani, Gary G.; Dowlatshahi, Kambiz

doi:10.1007/bf01659046

Cited by 37 publications

(20 citation statements)

References 24 publications

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“…The incidence of proximal tumours in Western countries has steadily increased while that of distal tumours has shown a corresponding decrease. 4,[42][43][44][45][46][47] When populations migrate from low-risk to high-risk areas, the CRC incidence quickly approaches that of the host country, with the largest increase occurring in the distal colon. 48 Taken together, the above geographic, age and gender influences on CRC subsite distribution, in concert with the observations on proximal shift and migrant studies, suggests the existence of 2 broadly different mechanisms of CRC.…”

Section: Epidemiologic Differences In the Incidence Of Right And Leftmentioning

confidence: 99%

Are there two sides to colorectal cancer?

Iacopetta

2002

Intl Journal of Cancer

697

558

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Colorectal carcinomas (CRC) that arise proximal (right) or distal (left) to the splenic flexure exhibit differences in incidence according to geographic region, age and gender. Together with observations that tumours in the hereditary cancer syndromes HNPCC and FAP occur predominantly in the right and left colon, respectively, the existence of 2 categories of CRC based on site of origin in the large bowel was proposed more than a decade ago. Differences between normal right and left colonic segments that could favour progression through different tumourigenic pathways are summarized in this review. Accumulating evidence suggests that the risk of CRC conferred by various environmental and genetic factors is different for proximal and distal tumours. Right-and left-sided tumours also exhibit different sensitivities to fluorouracil-based chemotherapy. Such differences are probably related to the molecular characteristics of the tumours, with the microsatellite instability and CpG island methylator phenotypes being associated with right-sided tumours and chromosomal instability with left-sided tumours. Future molecular-based classification systems for CRC that rely upon distinctive gene expression patterns may allow a clearer discrimination of subgroups than that provided by tumour site alone. Until then however, the existence of 2 broadly different groups of cancer defined by site of origin in the colon should be considered in the design of future epidemiologic studies as well as in the design of new clinical trials aimed at testing novel adjuvant therapies.

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Section: Epidemiologic Differences In the Incidence Of Right And Leftmentioning

confidence: 99%

Are there two sides to colorectal cancer?

Iacopetta

2002

Intl Journal of Cancer

697

558

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“…No nosso estudo, foram encontrados 31,10% das lesões no cólon direito. Num estudo analisando a distribuição dos tumores colorretais em 1.694 neoplasias durante os períodos de 1960-1969, 1970-1979 e 1980-1984, foi observado um decrés-cimo final de 15,80% para neoplasias do reto e um aumento de 10,20% para as do cólon direito, evidenciando essa mudança de comportamento do câncer colorretal 18 .…”

Section: Tabela 5 -Relação Entre O Tipo Histológico Do Adenoma E O Grunclassified

Aspectos epidemiológicos dos pólipos e lesões plano-elevadas colorretais

Neto

Arcieri²,

Teixeira³

2010

Rev bras. colo-proctol.

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INTRODUÇÃOOs pólipos colorretais são estruturas que se projetam na superfície da camada mucosa do intestino grosso, podendo ser neoplásicos ou não 1 .Foi Morson, em 1976, quem melhor estabeleceu uma classificação para os diversos tipos de pó-lipos e a importância da progressão adenoma-câncer. Os pólipos foram divididos em: pólipos neoplásicos, caracterizados pelos adenomas e os carcinomas, e os pólipos não-neoplásicos, que incluem os tipos epiteliais hamartomatosos, inflamatórios, hiperplásicos ou metaplásicos 2 .Os pólipos adenomatosos, que correspondem a cerca de 70% de todos os pólipos, são conhecidamente lesões pré-malignas que antecedem, em 10 a 15 anos, o câncer colorretal 3,4 . Por conta dessa progressão lenta, a detecção de lesões pré-neoplásicas no intestino grosso é relevante na prevenção do surgimento e complicações do câncer colorretal. Os pólipos podem ser ressecados antes da sua malignização, diminuindo sobremaneira a taxa de morbimortalidade do câncer colorretal.A Japanese Research Society for Cancer of the Colon and Rectum classifica adenomas e cânceres colorretais em dois grupos: protruso e superficial. O tipo

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“…The matter is further complicated by the trend toward the proximal shift of colorectal cancer in the developed world with the need for more expensive invasive investigations (colonoscopy, and barium studies) as the optimal techniques for pro [per detection of these cancers instead of digital examination and proctosigmoidoscopy [8].…”

Section: Introductionmentioning

confidence: 99%

The Trend Towards the Right (Proximal) Shift of Colorectal Cancer: Is Not Observed in Sudanese Patients

Mirghani¹

2016

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Abstract:Background: There is a tendency of colorectal cancer towards a right shift, and increasing incidence among the young age groups. In this study, we aimed to assess the pattern of colorectal cancer among Sudanese patients attending an endoscopy unit in Omdurman Teaching Hospital. Subjects and Methods: This descriptive cross-sectional study conducted among thirty patients referred with the provisional diagnosis of colorectal cancer during the period from August 2015 to June 2016. Participants signed a written informed consent then interviewed to collect demographic data, symptoms related to carcinoma of the colon, the patients were then examined for evidence of anemia, intestinal obstruction, and ascites, colonoscopy with biopsy for histopathology was done. The ethical committee of the Omdurman Teaching Hospital approved the research, and the Statistical Package for Social Sciences (SPSS) was used for data analysis. Results; Out of thirty patients with the diagnosis of colorectal cancer, their ages ranged from 18-76 years with a mean of 51.1. The commonest presentations were rectal bleeding, change in the bowel habits, and constipation in 90%, 80%, and 60% respectively. Fourteen (46.7% were ≤ 50 years. The family history of colorectal cancer was evident in 16.7%, the recto-sigmoid area was the commonest site (83.3%), with 100% adenocarcinoma. Conclusion: Colorectal cancer tend to affect the younger age groups, the majority were recto-sigmoid (the proximal shift was not observed). The adenocarcinoma was the commonest histopathology.

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Colorectal carcinomas: Diagnostic implications of their changing frequency and anatomic distribution

Cited by 37 publications

References 24 publications

Are there two sides to colorectal cancer?

Are there two sides to colorectal cancer?

Aspectos epidemiológicos dos pólipos e lesões plano-elevadas colorretais

The Trend Towards the Right (Proximal) Shift of Colorectal Cancer: Is Not Observed in Sudanese Patients

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