Colorimetric and fluorescent sensors for detection of nerve agents and organophosphorus pesticides

Chen, Qian; Sun, Yudie; Liu, Bo; Zhang, Jian; Zhang, Cheng; Jiang, Hui; Han, Xinya; He, Lifang; Wang, Suhua; Zhang, Kui

doi:10.1016/j.snb.2021.130278

Cited by 102 publications

(34 citation statements)

References 84 publications

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“…Attributed to the attractive features of easy readout and real-time visual detection via naked eyes, the colorimetric sensing mode attracted wide attention in the field of detecting pesticides and related biomarkers [37,38]. In a typical ChE-CHO-nanozyme colorimetric platform, chromogenic substrates including TMB, ABTS, and OPD are usually used to be catalyzed by an HRP-like nanozyme with the participation of H 2 O 2 to produce color signals.…”

Section: Ternary Che-cho-nanozyme Assaysmentioning

confidence: 99%

“…Zhu's group prepared a peroxidase-like SAN with high-concentration Cu sites on carbon nanosheets and constructed an AChE-CHO-SAN cascade reaction system for the colorimetric detection of ACh and OPs [48]. Attributed to the attractive features of easy readout and real-time visual detection via naked eyes, the colorimetric sensing mode attracted wide attention in the field of detecting pesticides and related biomarkers [37,38]. In a typical ChE-CHO-nanozyme colorimetric platform, chromogenic substrates including TMB, ABTS, and OPD are usually used to be catalyzed by an HRP-like nanozyme with the participation of H2O2 to Although these ChE-CHO-nanozyme colorimetric assays exhibit a variety of merits and were widely applied for pesticide determination, most of them are performed in solution, which are inefficient and complex to operate for in-field detection.…”

Section: Ternary Che-cho-nanozyme Assaysmentioning

confidence: 99%

“…To highlight the progress in this field, here we intend to summarize the principles, methods, and applications of nanozyme-based sensors for pesticide and ChE detection. What should be stated is that although there are a number of thematic reviews on pesticide and related biomarker biosensing [15,[37][38][39][40][41][42][43][44], no reviews focus on the emerging applications of nanozymes in pesticide biosensors. Our contribution is expected to fill in the gap.…”

Section: Introductionmentioning

confidence: 99%

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Nanozyme-Participated Biosensing of Pesticides and Cholinesterases: A Critical Review

Zhu

Liu

et al. 2021

Biosensors

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To improve the output and quality of agricultural products, pesticides are globally utilized as an efficient tool to protect crops from insects. However, given that most pesticides used are difficult to decompose, they inevitably remain in agricultural products and are further enriched into food chains and ecosystems, posing great threats to human health and the environment. Thus, developing efficient methods and tools to monitor pesticide residues and related biomarkers (acetylcholinesterase and butylcholinesterase) became quite significant. With the advantages of excellent stability, tailorable catalytic performance, low cost, and easy mass production, nanomaterials with enzyme-like properties (nanozymes) are extensively utilized in fields ranging from biomedicine to environmental remediation. Especially, with the catalytic nature to offer amplified signals for highly sensitive detection, nanozymes were finding potential applications in the sensing of various analytes, including pesticides and their biomarkers. To highlight the progress in this field, here the sensing principles of pesticides and cholinesterases based on nanozyme catalysis are definitively summarized, and emerging detection methods and technologies with the participation of nanozymes are critically discussed. Importantly, typical examples are introduced to reveal the promising use of nanozymes. Also, some challenges in the field and future trends are proposed, with the hope of inspiring more efforts to advance nanozyme-involved sensors for pesticides and cholinesterases.

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Section: Ternary Che-cho-nanozyme Assaysmentioning

confidence: 99%

Section: Ternary Che-cho-nanozyme Assaysmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Nanozyme-Participated Biosensing of Pesticides and Cholinesterases: A Critical Review

Zhu

Liu

et al. 2021

Biosensors

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“…Materials research science has focused on detection devices that help identify chemical warfare agents while using less effort in miniaturizing the sensing tool. 8 Analytical applications in actual samples are extremely limited due to the rapid hydrolysis of nerve agent mimics under aqueous conditions. Therefore, nonaqueous systems can be easily used to monitor both absorption and fluorescence spectral shifts to identify nerve agents.…”

Section: Introductionmentioning

confidence: 99%

Cellulose Acetate–Cellulose Nanowhisker Nanocomposite Immobilized with a DCDHF-Hydrazone Chromophore toward a Smart Test Strip for Colorimetric Detection of Diethyl Chlorophosphate as a Nerve Agent Mimic

et al. 2022

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Exposure to nerve agents, which are usually colorless and odorless gases, may cause organ failure, paralysis, or even quick death. Diethyl chlorophosphate (DCP) has been recognized as one of the most well-known chemical warfare nerve agent mimics. In the current study, we introduce a simple strategy for the development of a portable and reversible nanocomposite-based microporous strip for naked-eye detection of DCP within a few seconds. A dicyanomethylenedihydrofuran hydrazone (DCDHF-H) chromophore was synthesized by an easy azo-coupling reaction and encapsulated in situ during the preparation of cellulose acetate/cellulose nanowhisker/hydrazone (CA-CNW-H) nanocomposites. These CA-CNW-H nanocomposites displayed a bathochromic shift in the absorption intensity of about 142 nm from 438 to 580 nm with the increase of the DCP concentration. The present CA-CNW-H sensor strip displayed a detection limit for DCP ranging from 25 to 200 ppm. The color change of CA-CNW-H from yellow to purple due to exposure to DCP was detected by CIE Lab analysis. The morphology, fibrous crystallinity, thermal stability, and mechanical properties of the prepared CA-CNW-H sensor strips were investigated.

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“…Moreover, another interesting field for their use is in the optical sensor field, where polymers have been used to create optical waveguides and special fibers [6]. Furthermore, a wide variety of optical sensitive coatings have been used for the detection of diverse variables, such as humidity, pH, temperature, electrical fields, chemicals, biological agents [7][8][9][10][11][12], and many others. The utilization of these polymeric materials has allowed us to obtain high precision sensors and improve the response of these sensors with better sensitivity and selectivity [13].…”

Section: Introductionmentioning

confidence: 99%

In Situ Synthesis of Gold Nanoparticles in Layer-by-Layer Polymeric Coatings for the Fabrication of Optical Fiber Sensors

et al. 2022

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A new method is proposed to tune the interferometric response of wavelength-based optical fiber sensors. Using the nanoparticle in-situ synthesis (ISS) technique, it is possible to synthesize gold nanoparticles (AuNPs) within a pre-existing polymeric thin film deposited at the end-face of an optical fiber. This post-process technique allows us to adjust the optical response of the device. The effect of the progressive synthesis of AuNPs upon polymeric film contributed to a remarkable optical contrast enhancement and a very high tuning capability of the reflection spectra in the visible and near-infrared region. The spectral response of the sensor to relative humidity (RH) variations was studied as a proof of concept. These results suggest that the ISS technique can be a useful tool for fiber optic sensor manufacturing.

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Colorimetric and fluorescent sensors for detection of nerve agents and organophosphorus pesticides

Cited by 102 publications

References 84 publications

Nanozyme-Participated Biosensing of Pesticides and Cholinesterases: A Critical Review

Nanozyme-Participated Biosensing of Pesticides and Cholinesterases: A Critical Review

Cellulose Acetate–Cellulose Nanowhisker Nanocomposite Immobilized with a DCDHF-Hydrazone Chromophore toward a Smart Test Strip for Colorimetric Detection of Diethyl Chlorophosphate as a Nerve Agent Mimic

In Situ Synthesis of Gold Nanoparticles in Layer-by-Layer Polymeric Coatings for the Fabrication of Optical Fiber Sensors

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