Colorimetric determination of mercury(II) via the inhibition by ssDNA of the oxidase-like activity of a mixed valence state cerium-based metal-organic framework

Wang, Caihong; Tang, Gonge; Tan, Hongliang

doi:10.1007/s00604-018-3011-3

Cited by 61 publications

(17 citation statements)

References 35 publications

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“…This group used the same Hg 2+ aptamer and signal amplification strategy to design a colorimetric aptasensor with detection limit of 49 pM [ 96 ]. Wang et al [ 97 ] moreover found that ssDNA bound a mixed-valence state cerium-based metal–organic framework (MVC-MOF), shielding its active sites and inhibiting its oxidase-like activity, while dsDNA activated its catalytic activity. In addition to Hg(II), the ion was bound to thymine-rich ssDNA (T-ssDNA) as a model DNA that caused formation of T-dsDNA if dsDNA was added.…”

Section: Aptasensors For Heavy Metals Ion Detectionmentioning

confidence: 99%

Advances in aptamer screening and aptasensors’ detection of heavy metal ions

et al. 2021

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Heavy metal pollution has become more and more serious with industrial development and resource exploitation. Because heavy metal ions are difficult to be biodegraded, they accumulate in the human body and cause serious threat to human health. However, the conventional methods to detect heavy metal ions are more strictly to the requirements by detection equipment, sample pretreatment, experimental environment, etc. Aptasensor has the advantages of strong specificity, high sensitivity and simple preparation to detect small molecules, which provides a new direction platform in the detection of heavy metal ions. This paper reviews the selection of aptamers as target for heavy metal ions since the 21th century and aptasensors application for detection of heavy metal ions that were reported in the past five years. Firstly, the selection methods for aptamers with high specificity and high affinity are introduced. Construction methods and research progress on sensor based aptamers as recognition element are also introduced systematically. Finally, the challenges and future opportunities of aptasensors in detecting heavy metal ions are discussed.

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Section: Aptasensors For Heavy Metals Ion Detectionmentioning

confidence: 99%

Advances in aptamer screening and aptasensors’ detection of heavy metal ions

et al. 2021

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“…Wang et al [ 41 ] found that double-stranded DNA (dsDNA) did not have the ability to inhibit the oxidase-like activity of a mixed-valence state cerium-based metal–organic framework (MVC-MOF). The difference in ability of ssDNA and dsDNA could be ascribed to the selective adsorption of ssDNA by MVC-MOF [ 42 ].…”

Section: Factors Affecting the Regulation By Ssdna Of Nanozyme Activitymentioning

confidence: 99%

“…This was because the substrate (H 2 O 2 ) can generate hydroxyl radicals during the catalytic process which induce DNA cleavage. Considering the high toxicity of the hydroxyl radical to DNA, Wang et al [ 41 ] developed a colorimetric sensor for Hg(II) detection based on the inhibition of the oxidase-like activity of MVC-MOF by thymine-rich ssDNA but not thymine-rich dsDNA. Under optimal conditions, the LOD was 10.5 nM based on S/N = 3, and high selectivity was verified by comparing the signals from other ions’ detection.…”

Section: Nanozyme-based Aptasensorsmentioning

confidence: 99%

Regulation Mechanism of ssDNA Aptamer in Nanozymes and Application of Nanozyme-Based Aptasensors in Food Safety

Wang

Zhou

et al. 2022

Foods

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Food safety issues are a worldwide concern. Pathogens, toxins, pesticides, veterinary drugs, heavy metals, and illegal additives are frequently reported to contaminate food and pose a serious threat to human health. Conventional detection methods have difficulties fulfilling the requirements for food development in a modern society. Therefore, novel rapid detection methods are urgently needed for on-site and rapid screening of massive food samples. Due to the extraordinary properties of nanozymes and aptamers, biosensors composed of both of them provide considerable advantages in analytical performances, including sensitivity, specificity, repeatability, and accuracy. They are considered a promising complementary detection method on top of conventional ones for the rapid and accurate detection of food contaminants. In recent years, we have witnessed a flourishing of analytical strategies based on aptamers and nanozymes for the detection of food contaminants, especially novel detection models based on the regulation by single-stranded DNA (ssDNA) of nanozyme activity. However, the applications of nanozyme-based aptasensors in food safety are seldom reviewed. Thus, this paper aims to provide a comprehensive review on nanozyme-based aptasensors in food safety, which are arranged according to the different interaction modes of ssDNA and nanozymes: aptasensors based on nanozyme activity either inhibited or enhanced by ssDNA, nanozymes as signal tags, and other methods. Before introducing the nanozyme-based aptasensors, the regulation by ssDNA of nanozyme activity via diverse factors is discussed systematically for precisely tailoring nanozyme activity in biosensors. Furthermore, current challenges are emphasized, and future perspectives are discussed.

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“…Recently, researchers are devoted to the development of fast, sensitive, and cost-effective portable biosensors for Hg 2+ , in which the methods generally include electrochemistry [ 16 , 17 ], field-effect transistors [ 18 ], surface plasmon resonance [ 19 , 20 ], Raman spectroscopy [ 21 ], colorimetric detection [ 22 , 23 ], and fluorescence [ 24 ]. Compared with traditional sensors, biochips can not only achieve high-throughput detection but also meet portability and efficiency [ 25 ], which have been developed to detect DNA [ 26 ], proteins/peptides [ 27 ], and heavy metal ions [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Detection of Mercury Ion with High Sensitivity and Selectivity Using a DNA/Graphene Oxide Hybrid Immobilized on Glass Slides

Gao

et al. 2021

Biosensors

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Excessive mercury ions (Hg2+) cause great pollution to soil/water and pose a major threat to human health. The high sensitivity and high selectivity in the Hg2+ detection demonstrated herein are significant for the research areas of analytical chemistry, chemical biology, physical chemistry, drug discovery, and clinical diagnosis. In this study, a series of simple, low-cost, and highly sensitive biochips based on a graphene oxide (GO)/DNA hybrid was developed. Hg2+ is detected with high sensitivity and selectivity by GO/DNA hybrid biochips immobilized on glass slides. The performance of the biosensors can be improved by introducing more phosphorothioate sites and complementary bases. The best limit of detection of the biochips is 0.38 nM with selectivity of over 10:1. This sensor was also used for Hg2+ detection in Dendrobium. The results show this biochip is promising for Hg2+ detection.

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Colorimetric determination of mercury(II) via the inhibition by ssDNA of the oxidase-like activity of a mixed valence state cerium-based metal-organic framework

Cited by 61 publications

References 35 publications

Advances in aptamer screening and aptasensors’ detection of heavy metal ions

Advances in aptamer screening and aptasensors’ detection of heavy metal ions

Regulation Mechanism of ssDNA Aptamer in Nanozymes and Application of Nanozyme-Based Aptasensors in Food Safety

Detection of Mercury Ion with High Sensitivity and Selectivity Using a DNA/Graphene Oxide Hybrid Immobilized on Glass Slides

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