Colorimetric determination of some penicillins and cephalosporins with 2-nitrophenylhydrazine hydrochloride

Korany, Mohamed A.; Abdel-Hay, Mohamed H.; Bedair, Mona M.; Gazy, Azza A.

doi:10.1016/0039-9140(89)80059-1

Cited by 15 publications

(3 citation statements)

References 7 publications

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“…Determination of penicillins and PCA using different techniques were reported, for example colorimetric method [3][4][5][6], HPLC, LC/ MS spcetropscopy [7][8][9][10][11][12] and enzyme linked immunosorbent assay [13].…”

Section: Introductionmentioning

confidence: 99%

Utility of surface enhanced Raman spectroscopy (SERS) for elucidation and simultaneous determination of some penicillins and penicilloic acid using hydroxylamine silver nanoparticles

El-Zahry

Refaat

Mohamed

et al. 2015

Talanta

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Section: Introductionmentioning

confidence: 99%

Utility of surface enhanced Raman spectroscopy (SERS) for elucidation and simultaneous determination of some penicillins and penicilloic acid using hydroxylamine silver nanoparticles

El-Zahry

Refaat

Mohamed

et al. 2015

Talanta

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“…Penicillins and cephalosporins have been thoroughly investigated in reverse‐phase high‐performance liquid chromatographic (RP‐HPLC) systems [] coupled with different methods of detection such as ultraviolet detection [], tandem mass spectrometry [], or chemiluminescence detection []. Since these compounds are small polar molecules, they could hardly be analyzed in RP‐HPLC mode without the addition of ion‐pairing reagent which serves to improve the retention and peak shape [].…”

Section: Introductionmentioning

confidence: 99%

Assessment of β‐lactams retention in hydrophilic interaction chromatography applying Box–Behnken Design

Jovanović

Rakić

Jančić–Stojanović

et al. 2012

J of Separation Science

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In this paper, the retention prediction models for mixture of β-lactam antibiotics analyzed by hydrophilic interaction chromatography (HILIC) are presented. The aim of the study was to investigate the retention behavior of some organic acids and amphoteric compounds including cephalosporins (cefotaxime, cefalexin, cefaclor, cefuroxime, and cefuroxime axetil) and penicillins (ampicillin and amoxicillin). Retention of substances with acidic functional group in HILIC is considered to be interesting since the majority of publications in literature are related to basic compounds. In the beginning of the study, classical silica columns were chosen for the retention analysis. Then, preliminary study was done and factors with the most significant influence on the retention factors were selected. These factors with the impact on the retention factors were investigated employing Box-Behnken design as a tool. On the basis of the obtained results the mathematical models were created and tested using ANOVA test and finally verified. This approach enables the presentation of chromatographic retention in many ways (three-dimensional (3-D) graphs and simple two-dimensional graphical presentations). All of these gave the possibility to predict the chromatographic retention under different conditions. Furthermore, regarding the structure of the analyzed compounds, the potential retention mechanisms in HILIC were suggested.

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“…Diclohexylcarbodiimide in ethanolic medium has been reported (116) to facilitate the colorimetric determination of seven nonsteroidal antiinflammatory drugs including flufenamic acid, mefenamic acid, niflumic acid, ketoprofen, ibuprofen, sodium diclofenac, and indomethacin. Procedures for the colorimetric determination of cephalosporins and penicillins have been reported that are based on the reaction of predecomposed cephalosporins with mercurochrome (117) or by direct reaction with 2-nitrophenylhydrazine hydrochloride in the presence of dicyclohexylcarbodiimide and pyridine (118). An extraction-spectrophotometric determination of amyzyl, arpenal, aprofen, diamiphen, tropacin, and estocin based on their interaction with ammonium tetrathiocyanocobaltate(II) in dichloroethane has been reported (119).…”

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confidence: 99%

Ultraviolet and light absorption spectrometry

Hargis¹,

Howell²

1992

Anal. Chem.

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with a B S In 1961, an M.S. in 1963. and a Ph D. in 1964. spent a year as a Postdoctoral Research Associate at Purdue University, and |olned the faculty at UNO in 1965. His present research Interests Include ultraviolet and light absorption spectrometry, reaction-rate analyses, heteropolymoiybdate chemistry, and on-line computer applications to chemical problems. He has authored or coauthored numerous research papers, an Instrumental analysis laboratory manual, an introductory analytical chemistry textbook, and chapters In several monographs dealing with spectrophotometry. Dr. Hargis holds membership in the American Chemical Society (Analytical and Education divisions). Phi Lambda Upsilon, and Sigma XI.

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Colorimetric determination of some penicillins and cephalosporins with 2-nitrophenylhydrazine hydrochloride

Cited by 15 publications

References 7 publications

Utility of surface enhanced Raman spectroscopy (SERS) for elucidation and simultaneous determination of some penicillins and penicilloic acid using hydroxylamine silver nanoparticles

Utility of surface enhanced Raman spectroscopy (SERS) for elucidation and simultaneous determination of some penicillins and penicilloic acid using hydroxylamine silver nanoparticles

Assessment of β‐lactams retention in hydrophilic interaction chromatography applying Box–Behnken Design

Ultraviolet and light absorption spectrometry

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