Utility of surface enhanced Raman spectroscopy (SERS) for elucidation and simultaneous determination of some penicillins and penicilloic acid using hydroxylamine silver nanoparticles

El-Zahry, Marwa R.; Refaat, Ibrahim H.; Mohamed, Horria A.; Rosenberg, Erwin; Lendl, Bernhard

doi:10.1016/j.talanta.2015.07.015

Cited by 39 publications

(15 citation statements)

References 25 publications

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“…The stronger band in this spectrum is observed at 1000 cm −1 , which is a Raman signature of PG, though its assignment has not been consensual in the literature. Hence, some authors have assigned this Raman band to the phenyl ring vibrational modes [8,9,12,39,40,42], while others assigned it to the presence of the beta lactam ring [11,38,41,44]. Nevertheless, for the magnetic-plasmonic substrates employed here, which differ in the average size of the Au NPs adsorbed at the surface, the SERS spectra always showed the band at about 1000 cm −1 .…”

Section: Resultsmentioning

confidence: 82%

“…Penicillin G (PG) belongs to the β-lactam antibiotics family whose structure is composed of a five-membered sulfur-containing thiazolidine ring fused to a beta-lactam ring and a phenyl ring attached to the side chain ( Figure S1, Supporting Information). The intensive use of PG as a pharmaceutical associated with the potential contamination of waters has raised interest in the SERS analysis of this antibiotic [8,9,11,12,[38][39][40][41][42][43][44]. To the best of our knowledge, there are no SERS studies on this analyte using magneto-plasmonic substrates.…”

Section: Introductionmentioning

confidence: 99%

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SERS Detection of Penicillin G Using Magnetite Decorated with Gold Nanoparticles

2017

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Sensitive and reliable procedures for detecting vestigial antibiotics are of great relevance for water quality monitoring due to the occurrence of such emergent pollutants in the aquatic environment. As such, we describe here research concerning the use of multifunctional nanomaterials combining magnetic and plasmonic components. These nanomaterials have been prepared by decorating magnetite nanoparticles (MNP) with colloidal gold nanoparticles (Au NPs) of distinct particle size distributions. Several analytical conditions were investigated in order to optimize the surface enhanced Raman scattering (SERS) detection of penicillin G (PG) dissolved in water. In particular, the dependence of the SERS signal by using distinct sized Au NPs adsorbed at the MNP was investigated. Additionally, microscopic methods, including Raman confocal microscopy, were employed to characterize the SERS substrates and then to qualitatively detect penicillin G using such substrates. For example, magnetic-plasmonic nanocomposites can be employed for magnetically concentrate analyte molecules and their removal from solution. As a proof of concept, we applied magneto-plasmonic nanosorbents in the removal of aqueous penicillin G and demonstrate the possibility of SERS sensing this antibiotic.

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Section: Resultsmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

SERS Detection of Penicillin G Using Magnetite Decorated with Gold Nanoparticles

2017

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“…Among them, the peak at 1007 cm −1 is the most prominent characteristic peak, which is derived from the benzene ring vibration, shown on the top-left side in Figure 5d. Note that the peak at 1594 cm −1 is another significant peak of ampicillin from C=C stretching; it is usually affected by background (or fluorescent interference) while in detection, making its intensity hard to compare [49]. On the other hand, the peaks at 852 cm −1 and a broad one at around 1300-1400 cm −1 are most probably attributed to Ag-O associated effect, which indicates, in this study, the interactions between Di NPs and Ag or Ag-O [50].…”

Section: Nps/ag Hns For Trace Detection Of Antibiotic Residue In Wmentioning

confidence: 99%

Dielectric Nanoparticles Coated upon Silver Hollow Nanosphere as an Integrated Design to Reinforce SERS Detection of Trace Ampicillin in Milk Solution

et al. 2020

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Surface-enhanced Raman scattering (SERS) technique is competent to trace detection of target species, down to the single molecule level. The detection sensitivity is presumably degraded by the presence of non-specific binding molecules that occupy a SERS-active site (or hot spot) on the substrate surface. In this study, a silver hollow nano-sphere (Ag HNS) with cavity has been particularly designed, followed by depositing dielectric nanoparticles (Di NPs) upon Ag HNS. In the integrated nanostructures, Di NPs/Ag HNS were furthermore confirmed by cutting through the cross sections using the Focused Ion Beam (FIB) technique, which provides the Scanning Electron Microscope (SEM) with Energy-dispersive Spectroscope (EDS) mode for identifying the distribution of Di NPs upon Ag HNS. The results have indicated that Di NPs/Ag HNS exhibits small diameter of cavity, and among Di NPs in this study, Al 2 O 3 with lower dielectric constant provides a much higher SERS enhancement factor (e.g.,~6.2 × 10 7 ). In this study, to detect trace amounts (e.g., 0.01 ppm) of Ampicillin in water or milk solution, Al 2 O 3 NPs/Ag HNS was found to be more efficient and less influenced by non-specific binding molecules in milk. A substrate with integrated plasmonic and dielectric components was designed to increase the adsorption of target species and to repulse non-specific binding molecules from SERS-active sites.Coatings 2020, 10, 390 2 of 15 techniques to provide rapid, food quality preserved, and bio-safety evaluation or analysis for related laboratories or industries [9][10][11].Surface-enhanced Raman scattering (SERS) technique delivers fingerprint information about a given substance using nearly roughened metal surfaces, metal nanoparticles (NPs), or metal nanostructures owing to their strong effect on the Raman-active peak(s) of target molecule. The enhancement of Raman-active modes is mainly due to the contribution of two effects through chemical mechanism (CM) and electromagnetic mechanism (EM) [12][13][14][15]. The CM depends on the adsorption of target molecules upon the "hot spots", which are generated at SERS-active sites; charge transfer occurs between the target molecule and the substrate, which may be enhanced by the polarizability of the molecule [16]. On the other hand, the EM relies on the physical attributes of the substrate as it is highly dependent on the composition, shape, and size of the metal substrate, which affect localized surface plasmon resonance (LSPR) in the metallic nanostructures. Therefore, available hot spots are formed in between the plasmonic nanostructures [15]. Aside from the mentioned factors, the intensity of SERS signals is also affected by the induced Raman laser wavelength, and thereafter, the interactions of target molecules toward the substrate [17,18].It has been widely accepted that the formation of Raman-active sites generates a highly enhanced EM field that leads to high enhancement factor (EF). The "hot spots" can be observed or even predicted using computer simulation and modeling to de...

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“…This technique has been used to detect antibiotics, finding 27 ng/mL for ampicillin, 29 ng/mL for penicillin G, 30 ng/mL for carbenicillin, and 28 ng/mL for penicilloic acid when using hydroxylamine gold NPs. This offers a promising methodology when detecting penicillin-related antibiotics, providing a new index for quantifying antibiotics [163].…”

Section: Surface-enhanced Raman Scattering (Sers)mentioning

confidence: 99%

Optical Biosensors for Therapeutic Drug Monitoring

et al. 2019

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Therapeutic drug monitoring (TDM) is a fundamental tool when administering drugs that have a limited dosage or high toxicity, which could endanger the lives of patients. To carry out this monitoring, one can use different biological fluids, including blood, plasma, serum, and urine, among others. The help of specialized methodologies for TDM will allow for the pharmacodynamic and pharmacokinetic analysis of drugs and help adjust the dose before or during their administration. Techniques that are more versatile and label free for the rapid quantification of drugs employ biosensors, devices that consist of one element for biological recognition coupled to a signal transducer. Among biosensors are those of the optical biosensor type, which have been used for the quantification of different molecules of clinical interest, such as antibiotics, anticonvulsants, anti-cancer drugs, and heart failure. This review presents an overview of TDM at the global level considering various aspects and clinical applications. In addition, we review the contributions of optical biosensors to TDM.

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Utility of surface enhanced Raman spectroscopy (SERS) for elucidation and simultaneous determination of some penicillins and penicilloic acid using hydroxylamine silver nanoparticles

Cited by 39 publications

References 25 publications

SERS Detection of Penicillin G Using Magnetite Decorated with Gold Nanoparticles

SERS Detection of Penicillin G Using Magnetite Decorated with Gold Nanoparticles

Dielectric Nanoparticles Coated upon Silver Hollow Nanosphere as an Integrated Design to Reinforce SERS Detection of Trace Ampicillin in Milk Solution

Optical Biosensors for Therapeutic Drug Monitoring

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