Colorimetric metasurfaces shed light on fibrous biological tissue

Haddadin, Zaid; Pike, Trinity C.; Moses, Jebin J.; Poulikakos, Lisa V.

doi:10.1039/d1tc02030g

Cited by 5 publications

(5 citation statements)

References 219 publications

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“…Metasurfaces revealing the tissue presence or structural arrangements of fibrous media can substantially empower the diagnostics of fibrosis, heart disease, and cancer. 77 Polarized light opens opportunities to accurately map the anisotropic properties of a fibrous medium that is typically composed of ordered structural proteins. Metasurfaces can enhance light interaction with the tissue and generate polarization-sensitive structural color, which reduces the analysis complexity typical of polarized light microscopy.…”

Section: ■ Cell Monitoringmentioning

confidence: 99%

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Metasurfaces for Quantitative Biosciences of Molecules, Cells, and Tissues: Sensing and Diagnostics

Barulin,

Nguyen,

Kim

et al. 2024

ACS Photonics

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Metasurfaces have revolutionized optical biosensing and diagnostic assays due to their sensitivity, compactness, and label-free operation. However, metasurface applications in analyzing complex biological systems and quantum bioscience phenomena remain scarce. In this Perspective, we discuss current developments in metasurface biosensors and propose promising future applications for probing or adopting quantum bioscience effects and improving spatial omics analysis in live cells and tissues. We discuss the capabilities of the current metasurface platforms for monitoring relevant biomarkers of viral diseases, neurodegenerative diseases, and cancers. Metasurfaceempowered examination of cell morphology and secretome, virus detection, and tissue imaging can improve the accuracy of early diagnosis. Furthermore, we review device-integration approaches for point-of-care testing settings that could constitute pathways toward technology commercialization. Altogether, we provide a perspective for exploring metasurface applications in precision health and medicine.

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Section: ■ Cell Monitoringmentioning

confidence: 99%

“…Metasurfaces revealing the tissue presence or structural arrangements of fibrous media can substantially empower the diagnostics of fibrosis, heart disease, and cancer . Polarized light opens opportunities to accurately map the anisotropic properties of a fibrous medium that is typically composed of ordered structural proteins.…”

Section: Cell Monitoringmentioning

confidence: 99%

Metasurfaces for Quantitative Biosciences of Molecules, Cells, and Tissues: Sensing and Diagnostics

Barulin,

Nguyen,

Kim

et al. 2024

ACS Photonics

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“…On a larger length scale, encoding chirality into plasmonic materials has enabled the manipulation of electromagnetic fields, and thus tailoring light−matter interactions, 1−3,5,7,9−12 and enhancing the sensitivity of chiral molecule detection, 2,[6][7][8]14 with the potential to enable early disease detection in tissues. 15 The potential to use chiral nanophotonic sensors to enhance molecular signals is appealing. However, the accurate measurement of molecular circular dichroism (CD) spectra in the ultraviolet region requires sensitive and expensive instrumentation.…”

Section: ■ Introductionmentioning

confidence: 99%

“…The handedness of a molecule underpins its function in biological systems, despite having an otherwise identical chemical nature as the enantiomeric counterpart. On a larger length scale, encoding chirality into plasmonic materials has enabled the manipulation of electromagnetic fields, and thus tailoring light–matter interactions, − ,,,− and enhancing the sensitivity of chiral molecule detection, ,− , with the potential to enable early disease detection in tissues . The potential to use chiral nanophotonic sensors to enhance molecular signals is appealing.…”

Section: Introductionmentioning

confidence: 99%

Molecular-Induced Chirality Transfer to Plasmonic Lattice Modes

et al. 2023

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Molecular chirality plays fundamental roles in biology. The chiral response of a molecule occurs at a specific spectral position, determined by its molecular structure. This fingerprint can be transferred to other spectral regions via the interaction with localized surface plasmon resonances of gold nanoparticles. Here, we demonstrate that molecular chirality transfer occurs also for plasmonic lattice modes, providing a very effective and tunable means to control chirality. We use colloidal self-assembly to fabricate non-close packed, periodic arrays of achiral gold nanoparticles, which are embedded in a polymer film containing chiral molecules. In the presence of the chiral molecules, the surface lattice resonances (SLRs) become optically active, i.e., showing handedness-dependent excitation. Numerical simulations with varying lattice parameters show circular dichroism peaks shifting along with the spectral positions of the lattice modes, corroborating the chirality transfer to these collective modes. A semi-analytical model based on the coupling of singlemolecular and plasmonic resonances rationalizes this chirality transfer.

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“…They have been studied since initial observations by Robert Hooke and Isaac Newton . Research has explored the generation of structural colors for various applications: biomedical sensing, − colored displays, − solar energy conversion, − information encryption, , and more. − However, full realization of these applications necessitates a deeper understanding of the mechanisms enabling control and tunability of color saturation, resonant wavelength, and colorimetric multiplexing.…”

Section: Introductionmentioning

confidence: 99%

Cutting Corners to Suppress High-Order Modes in Mie Resonator Arrays

Haddadin,

Khan,

Poulikakos

2023

ACS Photonics

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Mie resonators as lattice resonant metasurfaces have the capability to produce structural color. However, design criteria for these metasurfaces are still being investigated. In this work, we numerically examined how the two-dimensional nanostructure shape in a lattice array affects the colorimetric response of the metasurface under linearly polarized light excitation. First, it was realized through near-field examinations that nodes of high-order resonances are localized to the corners of the rectangle-shaped nanostructures, where fundamental resonance nodes cannot be found. Second, removing the corners in rectangle-shaped nanostructures to create t-shaped nanostructure arrays displayed a dampening effect on the high-order resonance. Finally, analytical calculations of the color saturation showed increases upon moving from rectangle-shaped to t-shaped nanostructure arrays when a high-order resonance was dampened. From these results, we present a design guideline for lattice resonant metasurfaces: Removing portions of the nanostructure that support only high-order resonances dampens these modes while maintaining support for fundamental resonances. These results present a first-principles criterion for engineering nanoparticles in lattice resonant metasurfaces, offering a new toolbox addition for polarized light-sensing and colorimetric applications.

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Colorimetric metasurfaces shed light on fibrous biological tissue

Abstract: Fiber-affecting diseases - encompassing fibrosis, heart disease, neurological disease and cancer - are directly linked to the density and reorganization of fibrous media in biological tissue. Polarized light has unique...

Cited by 5 publications

References 219 publications

Metasurfaces for Quantitative Biosciences of Molecules, Cells, and Tissues: Sensing and Diagnostics

Metasurfaces for Quantitative Biosciences of Molecules, Cells, and Tissues: Sensing and Diagnostics

Molecular-Induced Chirality Transfer to Plasmonic Lattice Modes

Cutting Corners to Suppress High-Order Modes in Mie Resonator Arrays

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