Colorimetric Response of Peptide‐Functionalized Gold Nanoparticles to Metal Ions

Abstract

Nano‐metal detectors! A rapid colorimetric response and detection limit in the nanomolar concentration range is achieved by a colorimetric sensor for metal ions. The sensor is made of gold nanoparticles functionalized with a simple peptide ligand (PFNs). The interaction of the PFNs with metal ions results in a distinct colorimetric response that is driven by nanoparticles aggregation (see figure).

Colorimetric detection of mercury, lead and copper ions simultaneously using protein-functionalized gold nanoparticles

“…And the charged, aromatic, and hydroxyl-containing amino acids can also interact with metal ions via noncovalent interactions (Slocik et al, 2008;Haas and Franz, 2009). Moreover, we supposed that during the procedure of functionalization of papain at pH 11.0, the structure of papain might change, which may favor the exposure of cysteine residues of papain.…”

Synthesis of Gold Nanoparticles to Capture Lifelike Proteins: Application on the Multichannel Sensor Array Design

“…The previously reported GNPs-based sensing strategies are mostly designed on the basis of aggregation [11,12], antiaggregation [13], and etching [14,15] mechanisms, thus specific designs and complicated surface modification of GNPs being generally inevitable. For example, Naik's group developed a peptide functionalized GNPs-based colorimetric sensing method for the detection of heavy metal ions [16]. Valentini et al described a highly sensitive point mutations probe based on DNA-conjugated GNPs [17].…”

Enhanced Sensitivity and Selectivity of Chemosensor for Malonate by Anchoring on Gold Nanoparticles

“…17 However, there are few gold nanoparticles (AuNPs)-type optical probes for dicarboxylate species in biology. As gold nanoparticles have tremendously high molar absorption in the visible region, they must have considerable potential for optical detection of small anions and molecules such as dicarboxylate.…”