Colorimetric signaling of Cu(II) ions by oxidative coupling of anilines with 4-aminoantipyrine

Polystyrene:β-Cyclodextrin Inclusion Complex-Supported Y2O3-Based Electrochemical Sensor: Effective and Simultaneous Determination of 4-Aminoantipyrine and Acyclovir Drugs

“…4-Aminoantipyrine (4-AAP) is a metabolite of aminophenazone and barely administered as an analgesic, antipyretic, and nonsteroid anti-inflammatory drug because of its possible side effects. 4-AAP residues in the environment possess a potential threat to human health, such as the risk of agranulocytosis; its use as a drug is discouraged. , Moreover, 4-AAP is utilized as a reagent for biochemical reactions constructing peroxides or phenols. , It is also used in the calorimetric detection of phenolic compounds and pesticides in the aquatic environment. , Because schiff bases of 4-AAP and its metal complexes are extensively used in the pharmaceutical industry, biochemical research, catalysis, clinical applications, and environmental monitoring . The toxic effect of 4-AAP on experimental animals was reported by the Occupational Safety and Health Administration .…”

Different Mathematical Spectrophotometric Methods for Determination of Ampyrone in Presence of Its Acid Degradation Product

“…Ampyrone is called 4-Aminoantipyrine (4amino-1,5-dimethyl-2-phenylpyrazole-3-one) and its analogues have shown a wide range of biological activities such as antirheumatic antiviral, anti-inflammatory, analgesic and antipyretic [4,5]. It used as a colorimetric detection for determination Cu 2+ in aqueous solution [6], Fe +2 in water [7] and determination of phenolic drugs via oxidative coupling reaction forming coloured products [8,9]. There are many methods for the determination of Ampyrone including solid-phase spectrophotometry [10], electrochemical method based on fabrication of multi-walled carbon nanotube electrodes for the estimation toxic drugs Ampyrone [11], electrochemical method by using graphite pencil electrode [12], LC/Mass spectrometry [13] and capillary electrophoresis [14].…”