Colorimetric Visual Sensors for Point-of-needs Testing

Krishnan, Sadagopan; Syed, Zia

doi:10.1016/j.snr.2022.100078

Cited by 30 publications

(11 citation statements)

References 151 publications

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“…The findings confirmed that optical sensors are useful for disease identification and quantification when combined with smartphones. Without complicated instrumentation, multiplexed optical sensors combined with smart detection and screening tools save time and money as practical diagnostic tools [ 56 , 57 ]. However, there are several drawbacks to smartphone-based optical sensors, such as the required optimization of lighting conditions [ 58 ].…”

Section: Smartphone-based Sensing Methodsmentioning

confidence: 99%

Smartphone-Based Multiplexed Biosensing Tools for Health Monitoring

et al. 2022

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Many emerging technologies have the potential to improve health care by providing more personalized approaches or early diagnostic methods. In this review, we cover smartphone-based multiplexed sensors as affordable and portable sensing platforms for point-of-care devices. Multiplexing has been gaining attention recently for clinical diagnosis considering certain diseases require analysis of complex biological networks instead of single-marker analysis. Smartphones offer tremendous possibilities for on-site detection analysis due to their portability, high accessibility, fast sample processing, and robust imaging capabilities. Straightforward digital analysis and convenient user interfaces support networked health care systems and individualized health monitoring. Detailed biomarker profiling provides fast and accurate analysis for disease diagnosis for limited sample volume collection. Here, multiplexed smartphone-based assays with optical and electrochemical components are covered. Possible wireless or wired communication actuators and portable and wearable sensing integration for various sensing applications are discussed. The crucial features and the weaknesses of these devices are critically evaluated.

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Section: Smartphone-based Sensing Methodsmentioning

confidence: 99%

Smartphone-Based Multiplexed Biosensing Tools for Health Monitoring

et al. 2022

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“…In this technique, color tags or enzymes are used for the detection of DNA compatible with the substrate. Alternatively, nucleic acids functionalized with nanomaterial-based assays can be used for the detection and quantification of DNA (Krishnan and Syed, 2022). During colorimetric analysis, colloidal solution gold Frontiers in Bioengineering and Biotechnology frontiersin.org nanoparticles (GNPs) exhibit different colors based on their distance from red to blue.…”

Section: Colorimetric-based Dna Sensors (Cms)mentioning

confidence: 99%

Nucleotide detection mechanism and comparison based on low-dimensional materials: A review

Azeem

Shafa²,

Aamir³

et al. 2023

Front. Bioeng. Biotechnol.

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The recent pandemic has led to the fabrication of new nucleic acid sensors that can detect infinitesimal limits immediately and effectively. Therefore, various techniques have been demonstrated using low-dimensional materials that exhibit ultrahigh detection and accuracy. Numerous detection approaches have been reported, and new methods for impulse sensing are being explored. All ongoing research converges at one unique point, that is, an impetus: the enhanced limit of detection of sensors. There are several reviews on the detection of viruses and other proteins related to disease control point of care; however, to the best of our knowledge, none summarizes the various nucleotide sensors and describes their limits of detection and mechanisms. To understand the far-reaching impact of this discipline, we briefly discussed conventional and nanomaterial-based sensors, and then proposed the feature prospects of these devices. Two types of sensing mechanisms were further divided into their sub-branches: polymerase chain reaction and photospectrometric-based sensors. The nanomaterial-based sensor was further subdivided into optical and electrical sensors. The optical sensors included fluorescence (FL), surface plasmon resonance (SPR), colorimetric, and surface-enhanced Raman scattering (SERS), while electrical sensors included electrochemical luminescence (ECL), microfluidic chip, and field-effect transistor (FET). A synopsis of sensing materials, mechanisms, detection limits, and ranges has been provided. The sensing mechanism and materials used were discussed for each category in terms of length, collectively forming a fusing platform to highlight the ultrahigh detection technique of nucleotide sensors. We discussed potential trends in improving the fabrication of nucleotide nanosensors based on low-dimensional materials. In this area, particular aspects, including sensitivity, detection mechanism, stability, and challenges, were addressed. The optimization of the sensing performance and selection of the best sensor were concluded. Recent trends in the atomic-scale simulation of the development of Deoxyribonucleic acid (DNA) sensors using 2D materials were highlighted. A critical overview of the challenges and opportunities of deoxyribonucleic acid sensors was explored, and progress made in deoxyribonucleic acid detection over the past decade with a family of deoxyribonucleic acid sensors was described. Areas in which further research is needed were included in the future scope.

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“…Quantitative determination of analyte concentration via visual color change can be subjective and thus reduces the overall accuracy of the detection system. Apart from this, uncontrollable and self‐aggregation of the nanomaterial in a complex sample matrix may generate false‐positive data along with high background signals (Krishnan, 2022). Recent developments include the incorporation of 2D materials such as graphene, transition metal oxides, and MXenes along with nanoparticles.…”

Section: Nano‐biosensors: a Step Towards Advanced Detection Platformsmentioning

confidence: 99%

Nano‐diagnostics as an emerging platform for oral cancer detection: Current and emerging trends

Chakraborty

Ghosh

Kumar

et al. 2022

WIREs Nanomed Nanobiotechnol

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Globally, oral cancer kills an estimated 150,000 individuals per year, with 300,000 new cases being diagnosed annually. The high incidence rate of oral cancer among the South-Asian and American populations is majorly due to overuse of tobacco, alcohol, and poor dental hygiene. Additionally, socioeconomic issues and lack of general awareness delay the primary screening of the disease. The availability of early screening techniques for oral cancer can help in carving out a niche for accurate disease prognosis and also its prevention. However, conventional diagnostic approaches and therapeutics are still far from optimal. Thus, enhancing the analytical performance of diagnostic platforms in terms of specificity and precision can help in understanding the disease progression paradigm. Fabrication of efficient nanoprobes that are sensitive, noninvasive, cost-effective, and less labor-intensive can reduce the global cancer burden. Recent advances in optical, electrochemical, and spectroscopy-based nano biosensors that employ noble and superparamagnetic nanoparticles, have been proven to be extremely efficient. Further, these sensitive nanoprobes can also be employed for predicting disease relapse after chemotherapy, when the majority of the biomarker load is eliminated. Herein, we provide the readers with a brief summary of conventional and new-age oral cancer detection techniques. A comprehensive understanding of the inherent challenges associated with conventional oral cancer detection techniques is discussed. We also elaborate on how nanoparticles have shown tremendous promise and effectiveness in radically transforming the approach toward oral cancer detection.

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Colorimetric Visual Sensors for Point-of-needs Testing

Cited by 30 publications

References 151 publications

Smartphone-Based Multiplexed Biosensing Tools for Health Monitoring

Smartphone-Based Multiplexed Biosensing Tools for Health Monitoring

Nucleotide detection mechanism and comparison based on low-dimensional materials: A review

Nano‐diagnostics as an emerging platform for oral cancer detection: Current and emerging trends

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