Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders

Playford, Raymond J.; Macdonald, Christopher; Johnson, Walter L.

doi:10.1093/ajcn/72.1.5

Cited by 330 publications

(247 citation statements)

References 83 publications

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“…Of course, many other factors found in colostrum/milk are likely to be acting via a lactocrine mechanism to affect development of the uterus and other reproductive and somatic tissues. It is well known that steroid and peptide hormones, cytokines, and growth factors are present in colostrum/milk (Grosvenor et al 1993, Osterlundh et al 1998, Playford et al 2000, Salmon et al 2009). Recently, microRNAs, which can regulate gene expression by silencing translation (Alvarez-Garcia & Miska 2005), were identified in human and bovine milk (Hata et al 2010, Kosaka et al 2010.…”

Section: Discussionmentioning

confidence: 99%

“…Evidence in several species indicates that colostrum, the first milk secreted after birth in mammals, acts as a conduit for transmission of signaling molecules from mother to offspring (Ogra et al 1977, Simmen et al 1990, Grosvenor et al 1993, Playford et al 2000, Almeida et al 2008, Langer 2009). Defined as lactocrine signaling (Yan et al 2006b, neonatal consumption of bioactive factors in colostrum affects differentiation of anterior pituitary mammotropes (Nusser & Frawley 1997), gastrointestinal tract development (Shulman 1990, Donovan & Odle 1994, Burrin et al 1995, and immune system maturation (Lonnerdal 2003, Field 2005, Kosaka et al 2010.…”

Section: Introductionmentioning

confidence: 99%

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Milk-borne lactocrine-acting factors affect gene expression patterns in the developing neonatal porcine uterus

Chen¹,

Frankshun²,

Wiley³

et al. 2011

Reproduction

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Lactocrine communication of milk-borne bioactive factors (MbFs) from mother to offspring through nursing can affect neonatal development with lasting consequences. Relaxin (RLX), a lactocrine-active peptide found in porcine colostrum, stimulates estrogen receptor-a (ESR1) expression required for uterine development shortly after birth (postnatal dayZPND 0). Whether other MbFs or cooperative lactocrine mechanisms affect the neonatal uterine developmental program is unknown. To determine the effects of age, nursing, and exogenous RLX on gene expression associated with uterine development, gilts (nZ4-5/group) were assigned to nurse ad libitum or to receive milk replacer, with or without exogenous RLX (20 mg/kg BW i.m./6 h for 48 h), from birth to PND 2 when uteri were collected. Body weight and uterine weight increased (P!0.05) similarly from birth to PND 2 in all gilts. However, colostrum consumption was required for normal uterine ESR1, vascular endothelial growth factor (VEGFA), matrix metalloproteinase 9 (MMP9), and RLX receptor (RXFP1) protein and/or transcript expression on PND 2. Uterine ESR1, VEGFA, and MMP9 protein levels were below (P!0.01) the assay sensitivity in replacer-fed gilts. Supplemental RLX increased (P!0.05) uterine ESR1 protein and mRNA in nursed gilts, as well as VEGFA protein in nursed and VEGFA mRNA in both nursed and replacer-fed gilts. RLX treatment did not affect uterine MMP9 mRNA levels. When compared with replacer-fed gilts on PND 2, uterine RXFP1 mRNA was reduced (P!0.05) in nursed gilts and in RLX-supplemented replacer-fed gilts. These results constitute the first evidence that establishment of the neonatal porcine uterine developmental program requires maternal lactocrine support.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Milk-borne lactocrine-acting factors affect gene expression patterns in the developing neonatal porcine uterus

Chen¹,

Frankshun²,

Wiley³

et al. 2011

Reproduction

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“…After maturity, humans gradually lose the immune and growth factors in the body. Aging, illness and death occur with the loss of immune and growth factors in the human body which can possibly be replaced in the human body with bovine colostrum [1] [3]. Since colostrum is a natural food, it can be consumed without experiencing side effects or drug interactions.…”

Section: Introductionmentioning

confidence: 99%

Influence of Colostrum on the Characteristics of Ice Cream

Mouton¹,

Aryana²

2015

FNS

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Colostrum is the first milk produced by a female mammal. It is high in protein, carbohydrate and antibodies. People are constantly looking for healthier food options including immune enhancing foods. Ice cream is a popular dairy dessert and the influence of colostrum on ice cream characteristics is not known. The objective was to study the impact of various amounts of colostrum on the key attributes of ice cream. Ice creams were manufactured with 0, 1.5, 3.0 and 4.5 g colostrum per pint (473 mL) of ice cream. Ice cream manufacture was replicated three times. Colostrum incorporation increased aerobic counts, apparent viscosity, but decreased meltdown resulting in slower melting of the ice creams and had no influence on flavor. In an attempt to make healthier ice creams, colostrum incorporation can be recommended in ice cream manufacture.

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“…24,25 Colostrum is rich in immunoglobulins, antimicrobial peptides (lactoferrin and lactoperoxidase) and a number of other bioactive molecules and growth factors. 26 The protein content is very high (B11% v/v), and the whey proteins include a-lactalbumin, b-lactoglobulin, serum albumin, immunoglobulins, lactoferrin and peptide hormones such as growth hormone 27 and insulin-like growth factors, 28 epidermal growth factor, 29 betacellulin, 27 transforming growth factor b 30 and platelet-derived growth factor. 26 In cell-lines, animal models 31,32 and human studies, 33 such growth factors have shown potential for proliferation and differentiation of both immature and mature cells in the gastrointestinal tract.…”

Section: Introductionmentioning

confidence: 99%

Randomised controlled trial of colostrum to improve intestinal function in patients with short bowel syndrome

et al. 2012

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BACKGROUND/OBJECTIVES: Colostrum is rich in immunoregulatory, antimicrobial and trophic components supporting intestinal development and function in newborns. We assessed whether bovine colostrum could enhance intestinal adaptation and function in adult short bowel syndrome (SBS) patients. SUBJECTS/METHODS: Twelve SBS patients in this randomised cross-over study received 4 weeks oral supplement of bovine colostrum or an iso-energetic and iso-proteinaceous control (2.4 MJ/d, 500 ml/day) separated by a 4-week washout period. Patients were admitted four times for 72-h periods of fluid, electrolyte and nutrient balance studies. Meals, faeces and urine were weighed, and energy, macronutrient and electrolyte contents were analysed to calculate net nutrient uptake. Body composition was measured by dual-energy X-ray absorptiometry scans, and functional tests of handgrip strength and lung functions were performed. Eight patients completed the study and were included in the analysis. RESULTS: Both supplements (colostrum and control) not only increased protein (0.96±0.42 MJ/d, P ¼ 0.004 1.03±0.44 MJ/d, P ¼ 0.003) and energy (1.46±1.02 MJ/d, P ¼ 0.005, 1.76±1.46 MJ/d, P ¼ 0.01) absorption but also absolute faecal wet weight excretions (231 ± 248 g/d, P ¼ 0.002, 319 ± 299 g/d, P ¼ 0.03), compared with baseline measurements. Both supplements improved handgrip strength (P ¼ 0.03) while only the control supplement increased lean body mass (1.12±1.33 kg, Po0.049). Colostrum was not found to be superior to the control. CONCLUSION: Intake of high-protein milk supplements increased net nutrient absorption for adult SBS patients, but at the expense of increased diarrhoea. Despite high contents of bioactive factors, colostrum did not significantly improve intestinal absorption, body composition or functional tests compared with the control.

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Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders

Cited by 330 publications

References 83 publications

Milk-borne lactocrine-acting factors affect gene expression patterns in the developing neonatal porcine uterus

Milk-borne lactocrine-acting factors affect gene expression patterns in the developing neonatal porcine uterus

Influence of Colostrum on the Characteristics of Ice Cream

Randomised controlled trial of colostrum to improve intestinal function in patients with short bowel syndrome

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