Colostrum-Induced Enteric Mucosal Growth in Beagle Puppies

Heird, William C.; Schwarz, Steven M.; Hansen, Inge

doi:10.1203/00006450-198406000-00005

Cited by 105 publications

(42 citation statements)

References 22 publications

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“…Studies in which newborn animals have been fed various combinations of formula, mature milk, or colostrum suggest that some component of colostrum stimulates tissue growth, particularly the gastrointestinal tract and liver (4,5). In addition, research with various mammalian species has identified a number of peptide growth factors, including insulin, IGF-I, and epidermal growth factor, that are present in higher concentrations in colostrum than in mature milk or formulas (6,7).…”

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confidence: 99%

Nutrient-Independent and Nutrient-Dependent Factors Stimulate Protein Synthesis in Colostrum-Fed Newborn Pigs

et al. 1995

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confidence: 99%

Nutrient-Independent and Nutrient-Dependent Factors Stimulate Protein Synthesis in Colostrum-Fed Newborn Pigs

et al. 1995

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“…Although the benefits of the consumption of nutrients and immune factors are readily apparent, the functional significance to the offspring of the numerous hormones and growth factors present in colostrum is unclear. Studies that have compared the growth of newborns have demonstrated an enhanced anabolic response, especially of the visceral organs, associated with colostrum feeding (1)(2)(3)(4). This response is often attributed to the presence of trophic factors, but this speculation remains to be proven.…”

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confidence: 99%

Nonnutritive Factors in Colostrum Enhance Myofibrillar Protein Synthesis in the Newborn Pig

et al. 2000

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Colostrum is a complex source of nutrients, immune factors, and bioactive substances consumed by newborn mammals. In previous work, we observed that protein synthesis in the skeletal muscle of newborn piglets is enhanced when they are fed colostrum rather than a nutrient-matched formula devoid of growth factors. To elucidate the mechanisms responsible for this response, we contrasted the fractional rates of sarcoplasmic and myofibrillar protein synthesis of newborn piglets that received only water with those fed for 24 h with colostrum, a nutrientmatched formula, or mature sow's milk. Compared with water, feeding resulted in a 2.5-to 3-fold increase in total skeletal muscle protein synthesis, and this increase was 28% greater in the colostrum-fed than either the formula-or mature milk-fed piglets. Feeding also stimulated muscle ribosome and total polyadenylated RNA accretion. Ribosomal translational efficiency, however, was similar across all fed groups. The greater stimulation of protein synthesis in colostrum-fed pigs was restricted entirely to the myofibrillar protein compartment and was associated with higher ribosome and myosin heavy chain mRNA abundance. Taken together, these data suggest that nonnutritive factors in colostrum enhance ribosomal accretion and musclespecific gene transcription that, in turn, stimulate specifically the synthesis of myofibrillar proteins in the skeletal musculature of the newborn. Abbreviations FSR, fractional synthesis rate MHC, myosin heavy chain GAPDH, glyceraldehyde phosphate dehydrogenase polyA, polyadenylated RNA rRNA, ribosomal RNA Colostrum is a source of nutrients, immune factors, and bioactive substances for the newborn mammal. Although the benefits of the consumption of nutrients and immune factors are readily apparent, the functional significance to the offspring of the numerous hormones and growth factors present in colostrum is unclear. Studies that have compared the growth of newborns have demonstrated an enhanced anabolic response, especially of the visceral organs, associated with colostrum feeding (1-4). This response is often attributed to the presence of trophic factors, but this speculation remains to be proven. In addition, inadequate consideration has been given to the fact that the consumption of colostrum also entails the ingestion of a larger quantity of nutrients than that typically provided by mature milk or many formulas. Thus, to distinguish between the stimulatory effects of macronutrient intake and the trophic effects of other growth-promoting substances in colostrum, we compared the protein synthetic response of newborn piglets to feeding with colostrum, mature sow's milk, or a formula with a macronutrient composition similar to that of colostrum but devoid of potentially bioactive molecules (5, 6). We observed that protein synthesis rates in skeletal and cardiac muscle, brain, and jejunum were higher in colostrum-fed than formulafed piglets; other organs did not show this enhanced response.The high rate of protein synthesis associated with col...

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“…However. previous studies of the effects of nursing and of natural milk on the small bowel have produced contradictory results (21)(22)(23)(24)(25). Furthermore, administration of one of these growth factors, EGF, to neonatal rats in artificial diet has been associated with growth of small intestine only when provided at concentrations much greater than those occumng naturally in rodent milk (26.…”

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Effects of Nursing on Growth and Development of Small Bowel Mucosa in Newborn Piglets

et al. 1991

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Colostrum-Induced Enteric Mucosal Growth in Beagle Puppies

Cited by 105 publications

References 22 publications

Nutrient-Independent and Nutrient-Dependent Factors Stimulate Protein Synthesis in Colostrum-Fed Newborn Pigs

Nutrient-Independent and Nutrient-Dependent Factors Stimulate Protein Synthesis in Colostrum-Fed Newborn Pigs

Nonnutritive Factors in Colostrum Enhance Myofibrillar Protein Synthesis in the Newborn Pig

Effects of Nursing on Growth and Development of Small Bowel Mucosa in Newborn Piglets

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