Colposcopic appearance of anal squamous intraepithelial lesions

Jay, Naomi; Berry, J. Michael; Hogeboom, Charissa J.; Holly, Elizabeth A.; Darragh, Teresa M.; Palefsky, Joel M.

doi:10.1007/bf02051199

Cited by 246 publications

(184 citation statements)

References 19 publications

Supporting

Mentioning

148

Contrasting

Unclassified

Order By: Relevance

“…The main abnormalities associated with high-grade lesions in our patient group were dense acetowhite epithelium associated with thick punctuation or mosaic patterns. A previous study had similar findings; vascular alterations, such as punctuation and mosaics, were more frequently associated with high-grade AIN, while micropapillae and condylomata were more associated with low-grade AIN; a mosaic pattern was uncommon in low-grade lesions [12].…”

Section: Discussionsupporting

confidence: 63%

“…Jay found that among anuscopic findings suggestive of condyloma, 91% were really low-grade lesions at biopsy and 8% high-grade AIN [12]. These findings reinforce the importance of investigating condylomatas, because they may hide a higher-grade lesion [10,12].…”

Section: Discussionmentioning

confidence: 86%

“…The technique of anuscopy under colposcopic vision is similar to that of cervical colposcopy [12]. Suspicious areas become acetowhite with the application of acetic acid, and vascular alterations manifest as punctations and mosaics.…”

Section: Individuals Infected By the Human Immunodeficiency Virus (Himentioning

confidence: 99%

See 2 more Smart Citations

Diagnostic methods for prevention of anal cancer and characteristics of anal lesions caused by HPV in men with HIV/AIDS

Pereira¹,

Lacerda²,

Barros³

2008

Braz J Infect Dis

View full text Add to dashboard Cite

Abnormalities found with anuscopy under colposcopic vision, anal cytology and anal biopsy were evaluated in 21 men with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) at the Federal University of Pernambuco Hospital in Brazil. Mean age was 38.4 ± 6.0 years, and mean time of HIV infection was 8.3 ± 5.1 years; 95.2% of the patients had been on highly active antiretroviral therapy (HAART) for an average of 6.6 ± 4.5 years. Mean CD4+ cell count was 482.2 ± 173.75 cells/mm 3 , and 80.9% presented a HIV viral load of < 5,000 copies/mL. Reported sexual preference was 52.4% homosexuals, 28.6% bisexuals, and 19.0%heterosexuals; 81% reported having had receptive anal intercourse and 61.9% reported more than 10 sexual partners of the same sex. Results of anuscopy under colposcopic vision revealed 17 (81.0%) low-grade lesions and/or condylomata or micropapillae and four (19.0%) high-grade lesions with or without condylomata. Among the 21 anal cytology examinations, seven (33.3%) revealed low-grade squamous intraepithelial lesions (LSIL); three (14.3%) presented atypical squamous cells of undetermined significance (ASCUS) and 11 (52.4%) were normal. Seventeen patients were submitted to anal biopsy with the following findings: three patients (17.6%) with normal epithelium, one (5.9%) with infection by HPV, three (17.6%) with condylomatas, two (11.8%) with AIN 1, four (23.6%) with AIN 2, three (17.6%) with AIN 3, and one (5.9%) with PAIN 2. Anuscopy under colposcopic vision was found to be useful for detecting anal lesions and for guiding anal biopsies. Anal cytology was less useful, as it underestimated the frequency of lesions.

show abstract

Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 86%

See 1 more Smart Citation

Diagnostic methods for prevention of anal cancer and characteristics of anal lesions caused by HPV in men with HIV/AIDS

Pereira¹,

Lacerda²,

Barros³

2008

Braz J Infect Dis

View full text Add to dashboard Cite

show abstract

“…Jay et al 24 utilizaram a magnificação de imagens e os parâmetros usados na colposcopia ginecológica em canal anal de 152 homens nos quais realizaram 358 biópsias. Concluíram que as imagens encontradas nos diferentes graus de neoplasias intraepiteliais evidenciadas eram similares àquelas descritas em colo uterino.…”

Section: Variáveisunclassified

Diagnóstico de HPV anal em mulheres com NIC: prevenção de câncer do ânus?

Capobiango

Filho²,

Afonso³

2009

Rev bras. colo-proctol.

View full text Add to dashboard Cite

Trabalho realizado no Programa de Pós-Graduação em Ciências Aplicadas à Cirurgia e à Oftalmologia da Faculdade de Medicina da Universidade Federal de Minas Gerais. Recebido em 23/02/2009 Aceito para publicação em 20/04/2009 INTRODUÇÃOA infecção pelo papilomavírus humano (HPV) acomete pessoas de qualquer idade, embora seja mais comum em jovens, provavelmente devido a mais atividade sexual nesse período. Sua associação com o ví-rus da imunodeficiência adquirida pode atingir 62% dos casos 1 .A associação entre HPV de alto risco e neoplasia de ânus em homens e mulheres com imunodeficiência ou imunossupressão está confirmada e as medidas relacionadas à vigilância estão padronizadas 1-3 . Em pacientes sem imunodeficiências, entretanto, essa associação ainda não está esclarecida, o que pode contribuir para a falta de normas adequadas para diagnosticar o HPV e prevenir o câncer de ânus [4][5][6] . A frequência do câncer de ânus antes considerada baixa encontra-se atualmente em elevação considerá-vel, principalmente o carcinoma de células escamosas (CCE). Concomitantemente a esse fato, tem sido constatado o aumento das infecções anogenitais por papilomavírus humano, que acomete 20% da população mundial sexualmente ativa 7 . A relação causal entre esse vírus e o câncer do colo do útero e do ânus

show abstract

“…However, the percentage of regression and progression of the lesions in these patients is unclear. 3,4 The HPV types implicated in anal intraepithelial neoplasia are similar to those described for the cervix, and it is not infrequent to observe infection by multiple types. 5 Since the prevalence of anal cancer has been increasing and the precursor conditions can be detected by screening methods, the relevance of using anal cytology and anoscopy as methods to as it leads lower rates of unsatisfactory slides.…”

Section: Introductionmentioning

confidence: 84%

HPV infection and intraepithelial lesions from the anal region: how to diagnose?

Carvalho¹,

Ferreira²,

Bueno³

2011

Braz J Infect Dis

View full text Add to dashboard Cite

In the last years, the prevalence of HPV infection in the anal region has increased, especially in some groups like homosexual and HIV-positive people. Since this infection can be associated with the development of squamous anal cancer due to its progression from HPV infection to anal intraepithelial neoplasia (AIN) and finally to cancer, the screening and evaluation of these conditions are important. Anal cytology and high resolution anoscopy are good methods that are available and can be used. Although useful, these methods should be performed correctly and not indiscriminately in all patients. Patients for whom anal cytology screening is recommended are: HIV-infected patients, homosexuals, women who present with high-grade vulvar squamous intraepithelial neoplasia, vulvar cancer or cervical cancer. An abnormal anal cytology should be further evaluated with high resolution anoscopy. Keywords: anal canal; papillomavirus infections; cell biology; carcinoma in situ.identify these pre-invasive lesions is being questioned. Such questions relate to the groups to be screened and the best way to implement it such screening. The purpose of this study was to review the literature about the use of anal cytology and anoscopy to screening and evaluation of anal intraepithelial neoplasia. ANAL CYTOLOGYAnal cytology is a noninvasive method of screening, which is performed primarily by anal secretion collection through a brush (Dacron swab) introduced into the anal canal and removed with gentle rotation movements. It is indicated to avoid anal sex and douching in the day before the procedure, since these practices can decrease cellular recovery. Special caution should be taken for not touching anal canal warts and rectum walls with the brush to avoid any fecal contamination.

show abstract

Colposcopic appearance of anal squamous intraepithelial lesions

Abstract: The colposcopic appearance of different grades of anal squamous intraepithelial lesions was similar to those described for the cervix. Incorporation of colposcopy into assessment of anal disease could aid in distinguishing anal LSIL from HSIL.

Cited by 246 publications

References 19 publications

Diagnostic methods for prevention of anal cancer and characteristics of anal lesions caused by HPV in men with HIV/AIDS

Diagnostic methods for prevention of anal cancer and characteristics of anal lesions caused by HPV in men with HIV/AIDS

Diagnóstico de HPV anal em mulheres com NIC: prevenção de câncer do ânus?

HPV infection and intraepithelial lesions from the anal region: how to diagnose?

Contact Info

Product

Resources

About