The seriousness and severity of the COVID-19 pandemic required high quality decision-making and quick, positive actions by different levels of government in Brazil and in other countries. The question is: How did the Brazilian government respond to the crisis caused by COVID-19 pandemic? We explored the theoretical context of the pandemic by using the Sendai framework, to analyze the quantitative aspects of the disease. The analysis was performed as an analytical, descriptive, and systematic study, using bibliographic research covering the period from Jan. 2020 to Apr. 2021. We used the process-tracing method. Brazil reported the first case of COVID-19 in South America, on Feb. 26. Since then, there has been an accelerated spread of the disease in South America. The Brazilian government’s responses to the pandemic were characterized by intergovernmental incoordination, caused by the lack of leadership from the federal government, resulting in increased losses in human lives.