Combating COVID-19 with integrated traditional Chinese and Western medicine in China

Liqiang, Ni; Chen, Lili; Huang, Xia; Han, Chouping; Xu, Jianrong; Zhou, Hong; Luan, Xin; Zhao, Yongfang; Xu, Jian‐Guang; Wang, Yuan; Chen, Hongzhuan

doi:10.1016/j.apsb.2020.06.009

Cited by 141 publications

(125 citation statements)

References 34 publications

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“…Even though the flexibility of gamma mangostin is not optimum (four rotatable bonds), but overall, the druglikeness of gamma mangostin is the best among other ligands. The efficacy of gamma mangostin in combating the viral-based disease is also suggested by some References [25,26]. Lopinavir is a standard protease drug in this research that shows the best physicochemical and pharmacochemical properties, as shown by its overlapping area on the hexagonal-shape.…”

Section: The Physicochemical and Pharmacochemical Analysis Of The Tesmentioning

confidence: 69%

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2020

Biointerface Res Appl Chem

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Section: The Physicochemical and Pharmacochemical Analysis Of The Tesmentioning

confidence: 69%

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2020

Biointerface Res Appl Chem

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“…According to the Diagnosis and Treatment Protocol for Coronavirus Pneumonia (Version 7) issued by the National Health Commission, several TCM formulae were recommended for different stages of the disease. Besides, three herbal formulas and three Chinese patent medicines (called San Fang San Yao) have also been screened out for the effective COVID-19 treatment [1] . The good clinical outcomes have been achieved by using the TCM treatment, suggesting the importance of TCM in the fight against the COVID-19.…”

Section: Introductionmentioning

confidence: 99%

Exploring the potential therapeutic effect of traditional Chinese medicine on coronavirus disease 2019 (COVID-19) through a combination of data mining and network pharmacology analysis

Sun

Jiang

Liu

2020

European Journal of Integrative Medicine

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Introduction Historically traditional Chinese medicine (TCM) has been used as treatment during epidemics. During the recent COVID-19 pandemic patients evidence suggests that the use of TCM has provided health benefits and has been successfully used to control the spread of the disease in China. The aim of this study was to systematically explore the TCM formulae which have been used for the prevention and treatment of pneumonia or ‘pestilence’ to investigate their compatibility with the Chinese materia medica (CMM) and understand their potential mechanisms in the treatment of COVID-19. Methods Frequency analysis was performed to identify high-frequency CMM and CMM groups. Association rules analysis was applied to investigate the compatibility law of CMMs and generate the commonly used CMM groups. Results A total of 173 prescriptions were collected. The frequency analysis showed that seven out of ten high-frequency CMMs overlapped with Lianhua Qingwen Capsules (LHQWC), and five high-frequency pair-CMMs and four triple-CMMs were included in LHQWC, respectively. Then three groups of CMM were generated from association rules analysis, one of which is Ma Xing Shi Gan Decoction (MXSGD). The results of the protein-protein interaction network and enrichment analysis showed that the potential therapeutic mechanisms of the generated prescriptions were involved in the anti-inflammatory, anti-viral, and neuroprotective effects. Conclusion This study showed the importance of systematic research on TCM prescriptions and provided candidate CMM groups that have the potential to treat COVID-19. In vitro and in vivo experiments should be conducted to validate these network pharmacology results, which can provide more information for the development of potential antiviral drugs from TCM prescriptions. The combination of TCM treatment and modern medical approaches will benefit patients with COVID-19 and help to overcome the current epidemic.

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“…Third, for patients in the convalescent period, it could improve symptoms, speed up the recovery, alleviate pulmonary inflammation, decrease adhesion, and help with functional recovery of damaged organs. Lastly, it could substantially reduce the cost of treatment [1].…”

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confidence: 99%

Traditional Chinese medicine for combating COVID-19

Chen

2020

Front. Med.

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COVID-19 is an emerging, rapidly evolving pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Due to its distinctive features in etiology, epidemiology and pathology, this infectious disease poses considerable diagnostic and therapeutic challenge [1]. Patients with COVID-19 mainly receive supportive care and symptom management, since there is no specific antiviral treatment yet for COVID-19. In addition to the principles of early quarantine, early detection, and early treatment [2], the early inclusion of traditional Chinese medicine (TCM) to the Chinese protocol, i.e., the integration of TCM and Western medicine, also contributed to the rapid containment of COVID-19 in China. TCM not only has a long history against the epidemic diseases but also plays a significant role in combating COVID-19.

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Combating COVID-19 with integrated traditional Chinese and Western medicine in China

Cited by 141 publications

References 34 publications

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Exploring the potential therapeutic effect of traditional Chinese medicine on coronavirus disease 2019 (COVID-19) through a combination of data mining and network pharmacology analysis

Traditional Chinese medicine for combating COVID-19

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