Combination analysis ofNOS3,ABCB1andIL23Rpolymorphisms with alcohol-induced osteonecrosis of the femoral head risk in Chinese males

Abstract

BackgroundCommon variants of multiple genes played a crucial role in osteonecrosis of the femoral head (ONFH) onset which was proved by many previous reports. We hypothesized that polymorphisms in NOS3, ABCB1 and IL23R were related to individual differences in alcohol sensitivity and the development of alcohol-induced ONFH.MethodsIn this case-control study, we evaluated 8 SNPs in three genes in the Chinese Han population including 355 male cases and 355 healthy male controls. These SNPs were genotyped by Sequenom MassARRAY RS1000. To identify their relationship with alcohol-induced ONFH susceptibility using χ2 test and genetic model analysis.ResultsWe found an association with alcohol-induced ONFH susceptibility for 4 SNPs (rs743506, rs3918184, rs13233308 and rs6693831) in three genes after adjusted by age. The genotype “G/A” of rs743506 in NOS3 gene acts as a risk factor in genotype (P = 0.003), dominant (P = 0.048), recessive (P = 0.005) and additive model(P = 0.006); The genotype “T/C” of rs3918184 in NOS3 gene acts as a risk factor in genotype (P = 0.012) and recessive model (P = 0.009); The genotype “T/C” of rs13233308 in ABCB1 gene acts as a risk factor in genotype (P = 0.038) and additive model(P = 0.041); The genotype “T/C” of rs6693831 in IL23R gene acts as a protective factor in genotype model (P = 0.046).ConclusionsThis study provides evidence for three alcohol-induced ONFH susceptibility genes (NOS3, ABCB1 and IL23R) in Chinese males and polymorphisms of them may be associated with alcohol-induced ONFH risk.

RAB40C Gene Polymorphisms Were Associated with Alcohol-Induced Osteonecrosis of the Femoral Head

“…21,22 In recent years, people began to pay attention to the relationship between hereditary susceptibility and alcohol-induced ONFH. [23][24][25] Our study on the relationship RAB40C gene polymorphisms and alcohol-induced ONFH is the novel study.…”

Variation and significance of serum leptin, blood lipid level, adiponectin, NO and TNF-α for patients with non-traumatic ischemic necrosis of the femoral head

“…Its pathogenic factors are complex, and the pathogenic factor determined includes chronic alcohol drinking, hormone injection, etc. (Wang et al, 2017). Therefore, researching on pathogenesis of INHF and molecular level variation of INHF patients is able to provide with theoretical basis for the treatment and prevention of INHF.…”

Association of MIR17HG and MIR155HG gene variants with steroid-induced osteonecrosis of the femoral head in the population of northern China

“…Osteonecrosis of the femoral head (ONFH), also known as avascularity necrosis of the femoral head, occurs mostly in young adults aged 30-50 and is a refractory disease in the Department of Orthopedics (Wang et al, 2017). Due to hidden early symptoms, most patients with osteonecrosis develop to the middle and late stages when they are diagnosed with osteonecrosis, and there are varying degrees of femoral head collapse or loss of hip joint function, which seriously affect the quality of life of patients (Xu et al, 2017;Zhang et al, 2017;Yuan et al, 2018).…”