Combination anti-HIV therapy via tandem release of prodrugs from macromolecular carriers

Danial, Maarten; Telwatte, Sushama; Tyssen, David; Cosson, Steffen; Tachedjian, Gilda; Moad, Graeme; Postma, Almar

doi:10.1039/c6py01882c

Cited by 26 publications

(23 citation statements)

References 52 publications

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“…So far, the examples shown usually involve two drug molecules maximum, however, it might be interesting the use of polymer chains bearing pendant cleavable disulfide-based prodrugs, so more drug molecules could be delivered. In particular, this approximation has been found to be successful in treating HIV, since it is possible to carry multiple drugs at a time thus leading to a more effective combination therapy [36,61]. Following a similar approximation, a polyethylene glycol block bearing a small amount of prodrugs (doxorubicin) on its side chain has been reported.…”

Section: Prodrugs Based On Self-immolative Spacersmentioning

confidence: 93%

Self-immolative chemistry in nanomedicine

Gisbert-Garzarán

Manzano

Vallet‐Regí

2018

Chemical Engineering Journal

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Self-immolative chemistry is based on the cascade of disassembling reactions triggered by the adequate stimulation and leading to the sequential release of the smaller constituent elements. This review will focus on the possibilities that this type of chemistry offers to nanomedicine research, which is an area where the stimuli responsive behavior is always targeted. There are some examples on the use of self-immolative chemistry for prodrugs or nanoparticles for drug delivery, but there is still an exciting land of opportunities waiting to be explored. This review aims at revising what has been done so far, but, most importantly, it aims at inspiring new research of self-immolative chemistry on nanomedicine.

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Section: Prodrugs Based On Self-immolative Spacersmentioning

confidence: 93%

Self-immolative chemistry in nanomedicine

Gisbert-Garzarán

Manzano

Vallet‐Regí

2018

Chemical Engineering Journal

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“…SFP is therefore a promising nano/microcarrier for safe drug delivery which may pave room for new opportunities to explore other drug conjugates. Among other studies, Daniel et al have reported that drug conjugates especially polymer conjugates are potentially suitable for the delivery of antiviral drugs [109,110]. A typical example is the synthesis of poly(lactideco-glycolide) nanoparticles loaded with a combination of reverse transcriptase and protease inhibitors.…”

Section: Mechanism Of Cleavage Methods Of Hydrolysis Referencesmentioning

confidence: 99%

Nano/Microparticles Encapsulation Via Covalent Drug Conjugation

Fasiku¹,

Amuhaya²,

Kingo³

et al. 2021

Nano- And Microencapsulation - Techniques and Applications

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Advancement in chemistry holds a great promise in improving drug encapsulation that leads to superior drug delivery efficiency and the therapeutic efficacy of nano/micro-delivery systems. Drugs are being designed to specifically access the infection sites via covalent conjugation to nano/micro-delivery systems. This chapter focuses on techniques for achieving covalent encapsulation of drugs in nano/micro-delivery systems, how conjugation is applied to selectively influence pharmacokinetic profile, intracellular, and extracellular uptake, specific targeting to disease sites, binding to specific receptors, and controlled/sustained release. In addition, the effect of conjugation on drug efficacy and biosafety of the micro/ nanoparticulate drug delivery systems are discussed.

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“…As human serum albumin comprises a single active cysteine residue (Cys-34) and constitutes up to 80% of serum thiols, potentially undergoing disulfide exchange prematurely causing antiviral prodrug release before cell uptake. Polymerdrug conjugates with unhindered disulfides linked to antiviral prodrugs showed stability in the presence 0.5 mM human serum albumin at 37°C and in turn suggests that drug release is selective upon cell i nternalization [23].…”

Section: Successful Disulfide Conjugatesmentioning

confidence: 99%