Combination of 2-methoxyestradiol (2-ME2) and eugenol for apoptosis induction synergistically in androgen independent prostate cancer cells

Ghosh, Rita; Ganapathy, Manonmani; Alworth, William L.; Chan, Daniel C.; Kumar, Addanki P.

doi:10.1016/j.jsbmb.2008.11.002

Cited by 54 publications

(33 citation statements)

References 33 publications

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“…67 Supporting the suggestion that the genotoxicity of estrogen metabolites is involved in prostate carcinogenesis is the observation of increased DNA strand breakage 52 and nuclear staining of 8-hydroxy-2′-deoxy-guanosine 60 in the prostates of rats treated with T plus E2. Conversely, increased expression or activity of COMT was shown to protect against estrogen-induced cancer by mediating the conversion of catechol estrogens into methoxyestrogens that have potent apoptotic activity against rapidly growing PCa cells, 68 prompting the testing of combinatory therapies involving methoxyestrogens and other standard therapies, such as hormone deprivation, 69 docetaxel, 70 and eugenol 71 against PCa growth in model systems.…”

Section: Influence Of Estrogen Bioactivation and Detoxification On Pcmentioning

confidence: 99%

Estrogens and Prostate Cancer: Etiology, Mediators, Prevention, and Management

Lee

Lam

et al. 2011

Endocrinology and Metabolism Clinics of North America

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The relationship between hormones and the pathogenesis of prostate cancer (PCa) has been studied extensively. All the mainstay targets for hormonal PCa therapies are based on negating androgen action. Recent epidemiologic and experimental data have clearly pinpointed the key roles of estrogens in PCa development and progression. Racial and geographical differences, as well as age-associated changes, in estrogen synthesis and metabolism contribute significantly to the etiology by increasing the ratio of circulating estrogen to androgen, sex hormone binding globulin synthesis, and aromatase activity and reducing androgen glucuronidation and tissue bioactivation. Promotion of aberrant cell growth, evasion of apoptosis, increased oxidative stress and inflammation, and gains in adiposity and bioactivation to genotoxic carcinogens during adulthood are probable mechanisms of estrogen carcinogenicity, while “estrogen imprinting” via epigenetics in early-life also determines PCa risk. Although the effects of estrogens are known to be mediated by genomic actions of the two estrogen receptor (ER) subtypes (ERα and ERβ), other non-canonical mediators, including the different ERβ isoforms, membrane and mitochondrial ERs, and G protein-coupled receptor 30, may have major actions diverging from classical ER actions. These new discoveries have led to renewed interest among the public and the medicinal field in estrogens and antiestrogens as singular and adjuvant PCa treatment and prevention regimens. This review summarizes current knowledge on how different estrogens/antiestrogens/estrogen mimics contribute to prostate carcinogenesis, the roles of the different mediators of estrogen in the process, and the potentials of new estrogenic/antiestrogenic compounds as targeted therapies for prevention and treatment of PCa.

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Section: Influence Of Estrogen Bioactivation and Detoxification On Pcmentioning

confidence: 99%

Estrogens and Prostate Cancer: Etiology, Mediators, Prevention, and Management

Lee

Lam

et al. 2011

Endocrinology and Metabolism Clinics of North America

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“…Although eugenol was shown to induce apoptosis in cancer cell lines, there are no reports on the effects of eugenol on the hallmark capabilities of chemically induced tumours in animal models (Yoo et al 2005;Pisano et al 2007;Ghosh et al 2009). Recently, we demonstrated that eugenol inhibits cell proliferation via suppression of nuclear factor-kappaB (NF-κB) signaling in a rat model of gastric carcinogenesis induced by N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) (Manikandan et al in press).…”

Section: Introductionmentioning

confidence: 99%

Eugenol induces apoptosis and inhibits invasion and angiogenesis in a rat model of gastric carcinogenesis induced by MNNG

et al. 2010

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“…Previous studies showed that eugenol has a strong anticancer potential against melanoma (Pisano et al, ), osteosarcoma (Shin et al, ), acute lymphoblastic leukemia and hepatocellular carcinoma (Khalafalla et al, ), gastric cancer (Manikandan, Vinothini, Priyadarsini, Prathiba, & Nagini, ), skin tumor (Kaur, Athar, & Alam, ), mast cells (Park et al, ), and prostate cancer (Ghosh, Ganapathy, Alworth, Chan, & Kumar, ). Sharma, Paliwal, Janmeda, and Sharma () reported that the enzyme, that is, glutathione and glutathione S‐transferase (protection against carcinogens) activity loss was recovered by MO pod extract.…”

Section: Resultsmentioning

confidence: 99%

Biological, nutritional, and therapeutic significance of Moringa oleifera Lam

Dhakad

Ikram

Sharma

et al. 2019

Phytotherapy Research

178

100

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The genus Moringa Adans. comprises 13 species, of which Moringa oleifera Lam. native to India and cultivated across the world owing to its drought and frost resistance habit is widely used in traditional phytomedicine and as rich source of essential nutrients. Wide spectrum of phytochemical ingredients among leaf, flower, fruit, seed, seed oil, bark, and root depend on cultivar, season, and locality. The scientific studies provide insights on the use of M. oleifera with different aqueous, hydroalcoholic, alcoholic, and other organic solvent preparations of different parts for therapeutic activities, that is, antibiocidal, antitumor, antioxidant, anti‐inflammatory, cardio‐protective, hepato‐protective, neuro‐protective, tissue‐protective, and other biological activities with a high degree of safety. A wide variety of alkaloid and sterol, polyphenols and phenolic acids, fatty acids, flavanoids and flavanol glycosides, glucosinolate and isothiocyanate, terpene, anthocyanins etc. are believed to be responsible for the pragmatic effects. Seeds are used with a view of low‐cost biosorbent and coagulant agent for the removal of metals and microbial contamination from waste water. Thus, the present review explores the use of M. oleifera across disciplines for its prominent bioactive ingredients, nutraceutical, therapeutic uses and deals with agricultural, veterinarian, biosorbent, coagulation, biodiesel, and other industrial properties of this “Miracle Tree.”

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Combination of 2-methoxyestradiol (2-ME2) and eugenol for apoptosis induction synergistically in androgen independent prostate cancer cells

Cited by 54 publications

References 33 publications

Estrogens and Prostate Cancer: Etiology, Mediators, Prevention, and Management

Estrogens and Prostate Cancer: Etiology, Mediators, Prevention, and Management

Eugenol induces apoptosis and inhibits invasion and angiogenesis in a rat model of gastric carcinogenesis induced by MNNG

Biological, nutritional, and therapeutic significance of Moringa oleifera Lam

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