Combination of Amino Acids Reduces Pigmentation in B16F0 Melanoma Cells

Ishikawa, Masago; Kawase, Ichiro; Ishii, Fumio

doi:10.1248/bpb.30.677

Cited by 27 publications

(27 citation statements)

References 31 publications

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“…However, none of these amino acids had significant inhibitory activity against mushroom TYR (Ishikawa et al 2007). Our results showed that under non-cytotoxic concentrations, treatment by GH could dose dependently inhibit TYR activity and reduce the melanin content to be comparable to that of arbutin in B16F10 melanoma cells; with the addition of α-MSH, GH-treated B16F10 cells could reduce the protein expression of melanogenic enzymes (TYR, TRP-1 and TRP-2) and MITF.…”

Section: Discussionmentioning

confidence: 70%

Glycine hydroxamate inhibits tyrosinase activity and melanin contents through downregulating cAMP/PKA signaling pathways

Lin

et al. 2014

Amino Acids

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Among the eight amino acid hydroxamates tested, Glycine hydroxamate (GH) was the best inhibitor of mushroom tyrosinase (TYR). With L-tyrosine as substrate, the GH inhibition of the monophenolase activity of the mushroom TYR was noncompetitive. GH decreased not only TYR protein expression, but also melanin content, tyrosinase-related protein (TRP)-1, TRP-2, and microphthalmia-associated transcription factor (MITF) expression in B16F10 melanoma cells while in the presence of α-melanocyte-stimulating hormone (α-MSH). GH also significantly decreased the isobutylmethylxanthine (IBMX)-induced increase in melanin content, which was not prevented by the ERK inhibitor PD98059. These results suggest GH has the potential for use in cosmetic hypopigmentation.

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Section: Discussionmentioning

confidence: 70%

Glycine hydroxamate inhibits tyrosinase activity and melanin contents through downregulating cAMP/PKA signaling pathways

Lin

et al. 2014

Amino Acids

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“…1,[27][28][29] Previously, we demonstrated that the simplest amino acid, glycine, inhibits spontaneous melanogenesis in B16F0 melanoma cells. 14) In that study, the inhibitory effect of glycine was similar to that of kojic acid, which is a typical tyrosinase inhibitor. However, kojic acid showed an inhibitory effect on mushroom tyrosinase activity while glycine did not.…”

Section: Discussionmentioning

confidence: 63%

“…[11][12][13] We previously demonstrated that glycine inhibits spontaneous melanogenesis in B16F0 melanoma cells, similar to kojic acid, which is a typical tyrosinase inhibitor. 14) However, in that study, glycine did not affect crude tyrosinase activity, therefore the mechanisms of the inhibitory effect of glycine on melanogenesis are unclear.…”

mentioning

confidence: 67%

Glycine Inhibits Melanogenesis in Vitro and Causes Hypopigmentation in Vivo

Ishikawa¹,

Kawase²,

Ishii³

2007

Biological & Pharmaceutical Bulletin

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“…The aim was to produce oligopeptides with high tyrosinase inhibiting activity, that are neither cytotoxic nor mutagenic A number of peptide fragments have been shown to reduce pigment production [42][43][44].…”

Section: Other Botanicals As Potential Bleaching Agentsmentioning

confidence: 99%

Melasma, Novel Treatment Modalities

Abdallah¹

2014

Pigmentary Disorders

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Treatment of melasma remains challenging due to frequent relapses and the occurrence of post-inflammatory hyperpigmentation (PIH) following many interventions. Treatment goals are inhibition of melanin synthesis and transfer by sunscreens, sun avoidance and the use of bleaching agents on one hand and removal of already present pigment by peeling, lasers and light on the other hand. Triple combination creams (TCC) (also known as Kligman's formula utilizing hydroquinone and modifications of Kligman's formula) remain the mainstay of treatment. Newer bleaching agents derived from plants and synthetic compounds have been introduced and many of them are promising safe substitutes for hydroquinone.Peeling agents especially superficial and medium depth peels are effective treatment modalities for melasma. Newer peeling agents are less irritating and may thus lead to fewer side effects. Q-switched lasers, which target melanin, have led to PIH until the innovation of "laser toning" and fractional Qswitched ruby, which have better outcomes. Fractional non-ablative and ablative lasers are useful at lower fluencies. Pulsed dye laser, which targets the vascular component in melasma, is promising with less melasma rebound.Combinations of the above-mentioned modalities usually have a better treatment outcome than either alone. This review will focus on the more recently introduced therapies.

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Combination of Amino Acids Reduces Pigmentation in B16F0 Melanoma Cells

Cited by 27 publications

References 31 publications

Glycine hydroxamate inhibits tyrosinase activity and melanin contents through downregulating cAMP/PKA signaling pathways

Glycine hydroxamate inhibits tyrosinase activity and melanin contents through downregulating cAMP/PKA signaling pathways

Glycine Inhibits Melanogenesis in Vitro and Causes Hypopigmentation in Vivo

Melasma, Novel Treatment Modalities

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