Combination of change in hematological parameters with exercise stress test to predict coronary artery disease

Korkmaz, Ahmet; Yıldız, Abdülkadir; Duyuler, Pınar Türker; Duyuler, Serkan; Yılmaz, Samet; Başyiğit, Funda; Elalmış, Özgül Uçar; Güray, Ümit; İleri, Mehmet

doi:10.1002/jcla.22205

Cited by 8 publications

(7 citation statements)

References 28 publications

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“…These consisted of 76,002 participants from 11 case–control, 9 cohort, and 18 cross-sectional studies. There were 16, 6, 10, and 5 studies that, respectively, reported stable CAD [ 10 – 17 , 19 – 26 ], ACS [ 27 – 32 ], stroke [ 33 – 42 ], and composite CVD outcomes [ 43 – 47 ]. One study [ 18 ] reported both CAD and ACS.…”

Section: Resultsmentioning

confidence: 99%

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Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis

Angkananard

Anothaisintawee

McEvoy

et al. 2018

BioMed Research International

250

181

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Objective This systematic review aimed to measure the association between neutrophil lymphocyte ratio (NLR) and cardiovascular disease (CVD) risk. Methods Relevant studies were identified from Medline and Scopus databases. Observational studies with NLR as a study factor were eligible for review. The outcomes of interest were any type of CVD including acute coronary syndrome, coronary artery disease, stroke, or a composite of these cardiovascular events. Mean differences in NLR between CVD and non-CVD patients were pooled using unstandardized mean difference (USMD). Odds ratios of CVD between high and low NLR groups were pooled using a random effects model. Results Thirty-eight studies (n=76,002) were included. High NLR was significantly associated with the risks of CAD, ACS, stroke, and composite cardiovascular events with pooled ORs of 1.62 (95% CI: 1.38-1.91), 1.64 (95% CI: 1.30, 2.05), 2.36 (95% CI: 1.44, 2.89), and 3.86 (95% CI: 1.73, 8.64), respectively. In addition, mean NLRs in CAD, ACS, and stroke patients were significantly higher than in control groups. Conclusion High NLR was associated with CAD, ACS, stroke, and composite cardiovascular events. Therefore, NLR may be a useful CVD biomarker.

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Section: Resultsmentioning

confidence: 99%

“…Among 17 studies of 8,988 subjects, 4 studies [ 14 , 16 , 20 , 23 ] reported ORs of high versus low NLR, 8 studies [ 10 – 12 , 17 , 19 , 21 , 22 , 26 ] reported mean differences of NLR between CAD and non-CAD patients, and 5 studies [ 13 , 15 , 18 , 24 , 25 ] reported both.…”

Section: Resultsmentioning

confidence: 99%

Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis

Angkananard

Anothaisintawee

McEvoy

et al. 2018

BioMed Research International

250

181

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“…Of the five studies investigating the impact of acute exercise on the PLR, three showed increased values post-exercise, indicating an inflammatory response (see Table 2 ). Considering exercise-induced thrombocytosis instead of neutrophilia, PLR might, therefore, serve as a useful alternative or addition to NLR, as indicated by increases in both markers in response to acute exercise in healthy (Wahl et al 2020 ) and diseased populations (Korkmaz et al 2018 ). Interestingly, PLR values were altered more profoundly by high intensity exercise modalities with values around twice higher than at rest and absolute values over 200 (Wahl et al 2020 ).…”

Section: Current State Of Knowledge—nlr Plr and Sii In Exercise Physiologymentioning

confidence: 99%

Transferring clinically established immune inflammation markers into exercise physiology: focus on neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and systemic immune-inflammation index

et al. 2021

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Over the last decades the cellular immune inflammation markers neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and systemic immune-inflammation index (SII = NLR × platelets) have emerged in clinical context as markers of disease-related inflammation and are now widely appreciated due to their integrative character. Transferring these clinically established inflammation markers into exercise physiology seems highly beneficial, especially due to the low temporal, financial and infrastructural resources needed for assessment and calculation. Therefore, the aim of this review is to summarize evidence on the value of the integrative inflammation markers NLR, PLR and SII for depiction of exercise-induced inflammation and highlight potential applications in exercise settings. Despite sparse evidence, multiple investigations revealed responsiveness of the markers to acute and chronic exercise, thereby opening promising avenues in the field of exercise physiology. In performance settings, they might help to infer information for exercise programming by reflecting exercise strain and recovery status or periods of overtraining and increased infection risk. In health settings, application involves the depiction of anti-inflammatory effects of chronic exercise in patients exhibiting chronic inflammation. Further research should, therefore, focus on establishing reference values for these integrative markers in athletes at rest, assess the kinetics and reliability in response to different exercise modalities and implement the markers into clinical exercise trials to depict anti-inflammatory effects of chronic exercise in different patient collectives.

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“…It has been also suggested that the NLR can provide a good measure of exercise stress and subsequent recovery since in the hours following recovery from exercise the blood neutrophil count continues to increase and the blood lymphocyte count decreases 7 . NLR has been reported to increase significantly following exercise stress test with subjects who had coronary artery disease, whereas in subjects with a positive exercise test outcome this increase has been even more significant 8 . The NLR usually returns to normal within six to nine hours after exercise, but where the exercise has been particularly prolonged and stressful, the NLR may still be elevated at 24 hours post-exercise 9 .…”

Section: Discussionmentioning

confidence: 43%

Acute Phase Protein Increase in High Altitude Mountaineers

Saka

2017

Rev Bras Med Esporte

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Combination of change in hematological parameters with exercise stress test to predict coronary artery disease

Cited by 8 publications

References 28 publications

Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis

Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis

Transferring clinically established immune inflammation markers into exercise physiology: focus on neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and systemic immune-inflammation index

Acute Phase Protein Increase in High Altitude Mountaineers

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