Combination of counter current salting-out homogenous liquid–liquid extraction and dispersive liquid–liquid microextraction as a novel microextraction of drugs in urine samples

Akramipour, Reza; Fattahi, Nazir; Pirsaheb, Meghdad; Gheini, Simin

doi:10.1016/j.jchromb.2016.01.031

Cited by 50 publications

(9 citation statements)

References 42 publications

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“…SALLE–DLLME‐SFO–GC‐MS gave satisfactory results for all the tested samples, including air, water, soil, human urine, hedgehog serum and plasma. Although Akramipour et al have already reported a similar research about the two methods combination to extract amphetamine and methamphetamine in human urine (Akramipour et al , 2016), they only selected urine sample. All the commonly environmental samples in this work related to hydrosphere, biosphere, lithosphere and atmosphere were investigated.…”

Section: Resultsmentioning

confidence: 99%

The combination of two microextraction methods coupled with gas chromatography for the determination of pyrethroid insecticides in multimedia environmental samples: air, water, soil, urine and blood

Zhu

Niu

Zhang

et al. 2020

Water & Environment J

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The salting-out assisted liquid-liquid extraction (SALLE) combined with dispersive liquid-liquid microextraction based on the solidification of floating organic droplet (DLLME-SFO) has been first developed as a high preconcentration technique for the extraction of pyrethroid insecticides (PYRs) in multimedia environmental samples, including air, soil, water, human urine, hedgehog serum and plasma. GC-MS was the separation and determination technique. Under the optimum extraction conditions (sample pH 2; salting-out solution volume and pH, 2 mL and 3; extraction solution, 300 µL of 1-undecanol; centrifugation speed and time, 2000 rpm and 15 min) and determination conditions, a linearity range (R 2 = 0.9993-0.9999) was obtained in a range of 5-5000 ng/mL. The limits of detection based on a signal-to-noise ratio of 3 were between 1.5 and 6.1 ng/mL. The recoveries of the four PYRs ranged from 66 to 122%. The results demonstrated that this SALLE-DLLME-SFO-GC-MS method allowed the satisfactory enrichment, purification and determination results of PYRs in multimedia environmental samples.

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Section: Resultsmentioning

confidence: 99%

The combination of two microextraction methods coupled with gas chromatography for the determination of pyrethroid insecticides in multimedia environmental samples: air, water, soil, urine and blood

Zhu

Niu

Zhang

et al. 2020

Water & Environment J

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“…Akramipoura et al used CC-HLLE in combination with DLLME-SFO for drugs extraction from biological samples. The enrichment factor ranged between 157 and 168 [164].…”

Section: Perspectivementioning

confidence: 99%

Homogeneous liquid–liquid extraction as an alternative sample preparation technique for biomedical analysis

Hammad

Abdallah

Bedair

et al. 2021

J of Separation Science

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Liquid-liquid extraction is a widely used technique of sample preparation in biomedical analysis. In spite of the high pre-concentration capacities of liquidliquid extraction, it suffers from a number of limitations including time and effort consumption, large organic solvent utilization, and poor performance in highly polar analytes. Homogeneous liquid-liquid extraction is an alternative sample preparation technique that overcomes some drawbacks of conventional liquid-liquid extraction, and allows employing greener organic solvents in sample treatment. In homogeneous liquid-liquid extraction, a homogeneous phase is formed between the aqueous sample and the water-miscible extractant, followed by chemically or physically induced phase separation. To form the homogeneous phase, aqueous samples are mixed with water-miscible organic solvents, waterimmiscible solvents/cosolvents, surfactants, or smart polymers. Then, phase separation is induced chemically (adding salt, sugar, or buffer) or physically (changing temperature or pH). This mode is rapid, sustainable, and cost-effective in comparison with other sample preparation techniques. Moreover, homogeneous liquid-liquid extraction is more suitable for the extraction of delicate macromolecules such as enzymes, hormones, and proteins and it is more compatible with liquid chromatography with tandem mass spectrometry, which is a vital technique in metabolomics and proteomics. In this review, the principle, types, applications, automation, and technical aspects of homogeneous liquid-liquid extraction are discussed.

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“…Table 3 summarizes in detail these miniaturized applications for the enrichment of amphetamine and related substances in forensic matrices, with emphasis on the key characteristics on the developed methodologies. Table S3 (Supplementary Material) contains information regarding other techniques for the determination of these classes of compounds in the forensic context [ 40 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 100 , 104 , 105 , 129 , 130 , 131 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 , 156 , 157 , 158 , 159 , 160 , 161 , 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 ...…”

Section: Screening-controlled Drugs By Microextraction-based Techniquesmentioning

confidence: 99%

Application of Microextraction-Based Techniques for Screening-Controlled Drugs in Forensic Context—A Review

et al. 2021

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The analysis of controlled drugs in forensic matrices, i.e., urine, blood, plasma, saliva, and hair, is one of the current hot topics in the clinical and toxicological context. The use of microextraction-based approaches has gained considerable notoriety, mainly due to the great simplicity, cost-benefit, and environmental sustainability. For this reason, the application of these innovative techniques has become more relevant than ever in programs for monitoring priority substances such as the main illicit drugs, e.g., opioids, stimulants, cannabinoids, hallucinogens, dissociative drugs, and related compounds. The present contribution aims to make a comprehensive review on the state-of-the art advantages and future trends on the application of microextraction-based techniques for screening-controlled drugs in the forensic context.

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Combination of counter current salting-out homogenous liquid–liquid extraction and dispersive liquid–liquid microextraction as a novel microextraction of drugs in urine samples

Cited by 50 publications

References 42 publications

The combination of two microextraction methods coupled with gas chromatography for the determination of pyrethroid insecticides in multimedia environmental samples: air, water, soil, urine and blood

The combination of two microextraction methods coupled with gas chromatography for the determination of pyrethroid insecticides in multimedia environmental samples: air, water, soil, urine and blood

Homogeneous liquid–liquid extraction as an alternative sample preparation technique for biomedical analysis

Application of Microextraction-Based Techniques for Screening-Controlled Drugs in Forensic Context—A Review

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