Combination of curcumin and green tea catechins prevents dimethylhydrazine-induced colon carcinogenesis

Chemopreventive effects of Coltect, a novel dietary supplement, alone and in combination with 5-aminosalicylic acid in 1,2-dimethylhydrazine-induced colon cancer in rats

“…Among these are celecoxib and curcumin, which in combination demonstrated a synergistic effect in inhibiting the growth of CRC cells in vitro and in vivo [Shpitz et al 2006;Lev-Ari et al 2005a, 2005b. Other studies have shown that curcumin and green tea synergistically inhibit cell proliferation and induce apoptosis in the ACF rat model and that a combination of celecoxib and difluoromethylornithine can reverse DNA hypomethylation on CRC in rats [Xu et al 2010;Pereira et al 2004]. Amantana and colleagues [Amantana et al 2002] demonstrated that supplementing green tea with selenium increased the green tea's antimutagenic effects.…”

Effects of curcumin on bleomycin-induced oxidative stress in malignant testicular germ cell tumors

“…Animal studies have shown that curcumin prevents carcinogenesis in the colon (18) and breast (19). Curcumin exhibits potent in vitro antiproliferative and apoptosis-inducing activities in a range of human cancer cell lines, including those derived from cancers of the prostate, breast, ovary and colon (20-22), but no study has been carried out with regard to the effects of curcumin on oxidative stress in testicular cancer cells.…”

What is new in gastrointestinal cancer prevention - a review of the literature 2009-2010

“…Pojawiły się też badania nad synergistycznym wpływem zielonej herbaty i kurkuminy -wskaźnik proliferacji komórek rakowych zmniejszył się znacznie bardziej w grupie, której podawano jednocześnie obydwa badane składniki w porównaniu z grupą wyłącznie pijącą zieloną herbatę oraz w stosunku do grupy, której podawano wyłącznie kurkuminę [26].…”