Combination of etodolac and dexamethasone improves preemptive analgesia in third molar surgery: a randomized study

Ramires, Guilherme Andre Del' Arco; Santos, Anderson Maikon de Souza; Momesso, Gustavo Antônio Corrêa; Polo, Tárik Ocon Braga; Silva, William P P; Barbosa, Stéfany; Bassi, Ana Paula Farnezi; Faverani, Leonardo Pérez

doi:10.1007/s00784-020-03552-6

Cited by 9 publications

(7 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Preemptive analgesia is an important part of multimodal analgesia, and its value is increasingly recognized by clinicians and researchers. Some studies have found that preemptive analgesia can further improve postoperative pain in TKA patients [8][9][10]. However, the optimal preemptive analgesia regimen for TKA is controversial.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Positive Preemptive Analgesia Effectiveness of Pregabalin Combined with Celecoxib in Total Knee Arthroplasty: A Prospective Controlled Randomized Study

Zhou

Liu

Ding

et al. 2023

Pain Research and Management

View full text Add to dashboard Cite

Objective. The purpose of the present study (a randomized clinical trial) was to evaluate the preemptive analgesic effects of pregabalin combined with celecoxib in total knee arthroplasty (TKA). Methods. From January 2019 to June 2021, we enrolled 149 patients who underwent TKA and divided them into four groups: the placebo group (n = 36), celecoxib group (n = 38), pregabalin group (n = 38), and combination group (n = 37). Each group was given the corresponding preemptive analgesia regimen at 12 and 2 hours before surgery. The pain score at rest and upon movement, cumulative dosage of sufentanil, knee range of motion (ROM), high-sensitivityC-reactive protein (hs-CRP) level, and adverse effects were evaluated after TKA to compare the effects of the preemptive analgesia regimens among the four groups. Results. The pain scores upon movement were significantly lower in the combination group than in the other three groups at 6, 12, 24, and 48 hours after surgery ( P < 0.05 ). The cumulative dose of sufentanil within 48 hours after surgery was lowest in the combined group among the four groups ( P < 0.05 ). Hs-CRP, ROM, and postoperative nausea and vomiting (PONV) were within 72 hours after surgery significantly improved in the combination group compared with those of the three other groups ( P < 0.05 ). Conclusion. The preemptive analgesia regimen of pregabalin combined with celecoxib had positive effects on improving acute pain and reducing the cumulative dose of opioids after TKA. This trial is registered with ChiCTR2100041595.

show abstract

Section: Discussionmentioning

confidence: 99%

“…It can improve the pain threshold of patients and reduce the degree of pain experienced [7]. Many studies have demonstrated the positive efectiveness of preemptive analgesia in TKA [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Positive Preemptive Analgesia Effectiveness of Pregabalin Combined with Celecoxib in Total Knee Arthroplasty: A Prospective Controlled Randomized Study

Zhou

Liu

Ding

et al. 2023

Pain Research and Management

View full text Add to dashboard Cite

show abstract

“…As of today, the use of NSAIDs and corticosteroids in the control of postoperative pain and edema has become quite common. 6,12,13 Pre-operative application of these medications provides a reduction in pain, pain medication dosage and edema in the postoperative period. 6,14 Many studies have been conducted on the effects of preemptive use of NSAIDs on pain and edema control in surgical extraction of third molar teeth.…”

Section: Discussionmentioning

confidence: 99%

Effects of Single-Dose Preemptive Intravenous Dexketoprofen Trometamol and Ibuprofen on Pain and Edema Control Following Third Molar Surgery: A Prospective, Randomized, Double-Blind and Clinical Study

BİLGE¹,

Karakaya²,

BAYDAN³

et al. 2022

Turkiye Klinikleri J Dental Sci

View full text Add to dashboard Cite

This comparative study aims to investigate the single-dose preemptive effects of intravenous (IV) dexketoprofen trometamol, ibuprofen for pain and edema control in mandibular wisdom teeth surgery. Material and Methods: In this study, 75 patients were randomly divided into 3 groups. Group 1 received IV ibuprofen 60 min before surgery; Group 2 received IV dexketoprofen trometamol 60 min before surgery; Group 3 received IV placebo (100 cc saline) 60 min before surgery. The pain and facial swelling were evaluated. Postoperative pain was recorded with a Visual Analog Scale (VAS) during 24 h. The total recovery acetaminophen intake dose was recorded in the first 24 h. Also, a 3D surface imaging device was used in the evaluation of swelling. Results: There was no statistically significant difference in the pain between the ibuprofen and dexketoprofen groups. There was a statistically significant difference in the edema on the 2 nd day (T1) between the ibuprofen and dexketoprofen group (p=0.010). On the 2nd day edema, the amount of edema observed in the ibuprofen group was recorded as the least. Postoperative edema and pain were higher in the placebo group than in the other groups (p<0.05). Conclusion: The findings obtained in this study suggest that the preemptive application of IV ibuprofen and dexketoprofen is effective in the control of edema and pain compared to the placebo group after third molar surgery.

show abstract

“…The patients were no induced to consumed or not the drugs, only were informed that were usually drugs destined to relieve pain, edema and trismus and might be used only if were extremely necessary for a rescue way. The weighted average corresponding to the values of every subject in each group was obtained 21 .…”

Section: Methodsmentioning

confidence: 99%

A triple-blind randomized clinical trial of different associations between dexamethasone and non-steroids anti-inflammatories for preemptive action in third molar extractions

Momesso

Grossi-Oliveira

Silva

et al. 2021

Sci Rep

Self Cite

View full text Add to dashboard Cite

The aim of this study is to evaluate the preemptive analgesic effects of dexamethasone (DEX) alone or combined with non-steroidal anti-inflammatory drugs (NSAIDs) in third molar surgeries. The subjects were divided into five groups (n = 20 teeth/group); subjects received only 8 mg of dexamethasone 1 h before the surgical procedure (DEX group), or in combination with etodolac (DEX + ETO), ketorolac (DEX + KET), ibuprofen (DEX + IBU), loxoprofen (DEX + LOX). Paracetamol 750 mg was provided as the number of rescue analgesics (NRA). Salivary PGE2 expression was measured preoperatively and at 48 h. Edema and Maximum mouth opening (MMO) were measured postoperatively at 48 h and 7 days. A visual analog scale (VAS) was performed postoperatively at 6, 12, 24, 48, 72 h, and 7 days. Salivary expression of PGE2 showed a decrease only for the DEX group. Edema and MMO and NRA consumption showed no significant differences among the groups (P > 0.05). The VAS showed a significantly lower pain perception at 6 h after the surgery for the DEX + ETO and DEX + KET groups (P < 0.05). The combination of DEX and NSAIDS should be considered for preemptive acute postsurgical pain management in third molar surgery. In some drug associations such as dexamethasone 8 mg + NSAIDS (ETO and KET) in the pre-operative time, only a few rescue analgesics are necessary.

show abstract

Combination of etodolac and dexamethasone improves preemptive analgesia in third molar surgery: a randomized study

Cited by 9 publications

References 30 publications

Positive Preemptive Analgesia Effectiveness of Pregabalin Combined with Celecoxib in Total Knee Arthroplasty: A Prospective Controlled Randomized Study

Positive Preemptive Analgesia Effectiveness of Pregabalin Combined with Celecoxib in Total Knee Arthroplasty: A Prospective Controlled Randomized Study

Effects of Single-Dose Preemptive Intravenous Dexketoprofen Trometamol and Ibuprofen on Pain and Edema Control Following Third Molar Surgery: A Prospective, Randomized, Double-Blind and Clinical Study

A triple-blind randomized clinical trial of different associations between dexamethasone and non-steroids anti-inflammatories for preemptive action in third molar extractions

Contact Info

Product

Resources

About