Objectives: In this in vivo animal study, we evaluated the effect of plasma electrolytic oxidation (PEO) coating on the topographic and biological parameters of implants installed in rats with induced osteoporosis and low-quality bones. Materials and methods: In total 44 Wistar rats (Rattus novergicus), 6 months old, were submitted to ovariectomy (OXV group) and dummy surgery (SHAM group). After 90 days, the ELISA test was performed and the ovariectomy effectiveness was confirmed. In each tibial metaphysis, an implant with PEO coating containing Ca2+ and P5+ molecules were installed, and the other tibia received an implant with SLA acid etching and blasting (AC) (control surface). After 42 days, 16 rats from each group were euthanized, their tibias were removed for histological and immunohistochemical analysis (OPG, RANKL, OC and TRAP), as well as reverse torque biomechanics. Data were submitted to One-way ANOVA or Kruskal-Wallis tests, followed by a Tukey post-test; P < 0.05. Histological analyses showed higher bone neoformation values among the members of the PEO group, SHAM and OVX groups. Immunohistochemical analysis demonstrated equilibrium in all groups when comparing surfaces for TRAP, OC and RANKL (P > 0.05), whereas OPG showed higher PEO labeling in the OVX group (P < 0.05). Biomechanical analysis showed higher reverse torque values (N.cm) for PEO, irrespective of whether they were OVX or SHAM groups (P < 0.05). Conclusion: The results indicated that the PEO texturing method favored bone formation and showed higher bone maturation levels during later periods in osteoporotic rats.

The aim of this study is to evaluate the preemptive analgesic effects of dexamethasone (DEX) alone or combined with non-steroidal anti-inflammatory drugs (NSAIDs) in third molar surgeries. The subjects were divided into five groups (n = 20 teeth/group); subjects received only 8 mg of dexamethasone 1 h before the surgical procedure (DEX group), or in combination with etodolac (DEX + ETO), ketorolac (DEX + KET), ibuprofen (DEX + IBU), loxoprofen (DEX + LOX). Paracetamol 750 mg was provided as the number of rescue analgesics (NRA). Salivary PGE2 expression was measured preoperatively and at 48 h. Edema and Maximum mouth opening (MMO) were measured postoperatively at 48 h and 7 days. A visual analog scale (VAS) was performed postoperatively at 6, 12, 24, 48, 72 h, and 7 days. Salivary expression of PGE2 showed a decrease only for the DEX group. Edema and MMO and NRA consumption showed no significant differences among the groups (P > 0.05). The VAS showed a significantly lower pain perception at 6 h after the surgery for the DEX + ETO and DEX + KET groups (P < 0.05). The combination of DEX and NSAIDS should be considered for preemptive acute postsurgical pain management in third molar surgery. In some drug associations such as dexamethasone 8 mg + NSAIDS (ETO and KET) in the pre-operative time, only a few rescue analgesics are necessary.

O herpes-zóster é uma infecção viral causada pela reativação do vírus da varicela-zóster, que acomete geralmente a população idosa. O vírus da varicela, quando em estado dormente, se localiza nos gânglios trigeminais e quando reativado pode causar lesões no rosto e vesículas intra bucais. Esta doença pode afetar com maior prevalência pacientes imunossuprimidos e caracteriza-se por erupções maculopapulares distribuídas na região do nervo afetado, causando dores intensas, tremores e até parestesia. O diagnóstico do herpes zoster geralmente é estabelecido por meio do quadro clínico apresentado pelo paciente e o tratamento é voltado aos sintomas e à causa, optando pelo uso de medicações antivirais sistêmicas e tópicas. Este artigo relata o caso de uma paciente, do sexo feminino, leucoderma, sem problemas de saúde e tratamentos imunossupressores prévios, de 56 anos de idade, que deu entrada ao pronto socorro, tendo com queixa principal a dor extra oral em hemiface direita, com evolução rápida de três dias após exodontia.

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Objectives The aim of this study is to evaluate the preemptive analgesic effects of dexamethasone (DEX) alone or combined with non-steroidal anti-inflammatory drugs (NSAIDs) in third molar surgeries.Materials and Methods The subjects were divided into five groups (n = 20 teeth/group); subjects received only 8 mg of dexamethasone 1 hour before the surgical procedure (DEX group), or in combination with etodolac (DEX + ETO), ketorolac (DEX + KET), ibuprofen (DEX + IBU), loxoprofen (DEX + LOX). Paracetamol 750 mg was provided as the number of rescue analgesics (NRA). Salivary PGE2 expression was measured preoperatively and at 48 hours. Edema and Maximum mouth opening (MMO) were measured postoperatively at 48h and 7 days. A visual analog scale (VAS) was performed postoperatively at 6, 12, 24, 48, 72 hours, and 7 days.Results Salivary expression of PGE2 showed a decrease only for the DEX group. Edema and MMO and NRA consumption showed no significant differences among the groups (P > 0.05). The VAS showed a significantly lower pain perception at 6 hours after the surgery for the DEX + ETO and DEX + KET groups (P < 0.05).Conclusions The combination of DEX and NSAIDS should be considered for preemptive acute postsurgical pain management in third molar surgery. Clinical Relevance: In some drug associations such as dexamethasone 8 mg + NSAIDS (ETO and KET), and others, the isolated administration of a single dose of dexamethasone in the pre-operative time, only a few rescue analgesics are necessary.