Combination of exercise and calorie restriction exerts greater efficacy on cardioprotection than monotherapy in obese-insulin resistant rats through the improvement of cardiac calcium regulation

Palee, Siripong; Minta, Wanitchaya; Mantor, Duangkamol; Sutham, Wissuta; Jaiwongkam, Thidarat; Kerdphoo, Sasiwan; Pratchayasakul, Wasana; Chattipakorn, Siriporn C.; Chattipakorn, Nipon

doi:10.1016/j.metabol.2019.02.003

Cited by 19 publications

(13 citation statements)

References 43 publications

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“…Based on CR experimen cytokine, chemokine, and metabolic pathways are significantly regulated by CR the aging process. It is expected that a better understanding of senoinflam mechanisms will provide a basis for the discovery of molecular targets that modulate age-related chronic inflammatory conditions and enable the develop effective interventions to delay aging and prevent the occurrence of aging-assoc ├ Human, Mouse, Rat [181,[249][250][251] ER stress ↑ are also related to low levels of insulin [213,214], suppressed IGF signaling [215], i [209] and activation of AMPK [215,216] and antioxidant genes [209]. K neuroprotective and lifespan extension effects similar to CR in C. elegans [21 transcription of antioxidant genes, including manganese superoxide dismu FOXO3, both of which exert antioxidant effects [209].…”

Section: Discussionmentioning

confidence: 99%

Anti-Aging Effects of Calorie Restriction (CR) and CR Mimetics Based on the Senoinflammation Concept

et al. 2020

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Chronic inflammation, a pervasive feature of the aging process, is defined by a continuous, multifarious, low-grade inflammatory response. It is a sustained and systemic phenomenon that aggravates aging and can lead to age-related chronic diseases. In recent years, our understanding of age-related chronic inflammation has advanced through a large number of investigations on aging and calorie restriction (CR). A broader view of age-related inflammation is the concept of senoinflammation, which has an outlook beyond the traditional view, as proposed in our previous work. In this review, we discuss the effects of CR on multiple phases of proinflammatory networks and inflammatory signaling pathways to elucidate the basic mechanism underlying aging. Based on studies on senoinflammation and CR, we recognized that senescence-associated secretory phenotype (SASP), which mainly comprises cytokines and chemokines, was significantly increased during aging, whereas it was suppressed during CR. Further, we recognized that cellular metabolic pathways were also dysregulated in aging; however, CR mimetics reversed these effects. These results further support and enhance our understanding of the novel concept of senoinflammation, which is related to the metabolic changes that occur in the aging process. Furthermore, a thorough elucidation of the effect of CR on senoinflammation will reveal key insights and allow possible interventions in aging mechanisms, thus contributing to the development of new therapies focused on improving health and longevity.

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Section: Discussionmentioning

confidence: 99%

Anti-Aging Effects of Calorie Restriction (CR) and CR Mimetics Based on the Senoinflammation Concept

et al. 2020

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“…In the Otsuka Long‐Evans Tokushima Fatty rat model for T2DM, CR lowered haemoglobin A1c, blood glucose, cholesterol, triglycerides and circulating FAs, and lowered UCP2 expression and mitochondrial ROS production in the heart and aorta . CR for 6 weeks improved the metabolic phenotype of rats on a high‐fat diet, lowering obesity, insulin resistance and left ventricular dysfunction, as well as cardiac mitochondrial ROS production, membrane depolarization and swelling . Of note, these improvements were even more pronounced when exercise was combined with CR …”

Section: Lifestyle and Pharmacological Interventions To Target Mitochmentioning

confidence: 98%

“…182 CR for 6 weeks improved the metabolic phenotype of rats on a high-fat diet, lowering obesity, insulin resistance and left ventricular dysfunction, as well as cardiac mitochondrial ROS production, membrane depolarization and swelling. 183 Of note, these improvements were even more pronounced when exercise was combined with CR. 183 Signalling targets known to be activated by CR (and inhibited by a high-fat diet) include sirtuins (Sirt) 1 and 3.…”

Section: Dietary Interventionsmentioning

confidence: 98%

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Altered mitochondrial metabolism in the insulin‐resistant heart

et al. 2019

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Obesity‐induced insulin resistance and type 2 diabetes mellitus can ultimately result in various complications, including diabetic cardiomyopathy. In this case, cardiac dysfunction is characterized by metabolic disturbances such as impaired glucose oxidation and an increased reliance on fatty acid (FA) oxidation. Mitochondrial dysfunction has often been associated with the altered metabolic function in the diabetic heart, and may result from FA‐induced lipotoxicity and uncoupling of oxidative phosphorylation. In this review, we address the metabolic changes in the diabetic heart, focusing on the loss of metabolic flexibility and cardiac mitochondrial function. We consider the alterations observed in mitochondrial substrate utilization, bioenergetics and dynamics, and highlight new areas of research which may improve our understanding of the cause and effect of cardiac mitochondrial dysfunction in diabetes. Finally, we explore how lifestyle (nutrition and exercise) and pharmacological interventions can prevent and treat metabolic and mitochondrial dysfunction in diabetes.

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“…These two interventions are considered key methods in amelioration of the combined aged-obese condition, potentially attenuating both obesity- and aging-induced cardiac dysfunction and cardiovascular disease [ 1 ]. Mechanistically, both caloric restriction and exercise improve cardiac mitochondrial function, leading to improved left ventricular function in the obese condition [ 4 ]. In reality, however, it is difficult to maintain caloric restriction and exercise training for one’s entire life due to the physiological adaptation to starvation and decreased exercise performance with age.…”

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confidence: 99%