Combination of<i>Sargassum fusiforme</i>and<i>Pueraria lobata</i>Extracts Alleviates Postmenopausal Symptoms in Ovariectomized Rats

Lee, Minhee; Park, Soo‐Jeung; Moon, Yun-Jeong; In, Gyo; Kim, Jong Han; Kim, Sung Won; Lee, Mi-Hyang; Kim, Ok‐Kyung

doi:10.1089/jmf.2019.4555

Cited by 3 publications

(1 citation statement)

References 20 publications

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“…Estrogen deficiency due to menopause can lead to overweight, dyslipidemia, and osteoporosis. Addition of extracts of Sargassum fusiforme (Phaeophyceae) and Pueraria lobata (Plantae, Magnoliophyta) at ratios of 3:1 showed the potential for alleviating postmenopausal symptoms in ovariectomized rats, including overweight, dyslipidemia, and osteoporosis (Lee et al, 2020). The anti-ageing effects of oligosaccharides from green algae Ulva lactuca and Ulva prolifera (formerly Enteromorpha prolifera) were also investigated in mice, and it was demonstrated that these oligosaccharides were ideal candidate compounds used in pharmaceuticals for preventing ageing (Liu et al, 2019).…”

Section: Animal Studiesmentioning

confidence: 99%

Remarkable Natural Biological Resource of Algae for Medical Applications

Dai

Wang²,

Xu³

et al. 2022

Front. Mar. Sci.

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With increasing consumer awareness of the use of natural products in pharmaceuticals and medicine, it is noted that algae can be considered an appropriate source. Algae produce many bioactive components, which have application potential in pharmaceutical industries, such as fatty acids, phycobiliprotein, polysaccharides, phenolic compounds, carotenoids, and so on. However, it is still a long way before the truly widespread application of algae in medicine, and some research and technical bottlenecks still need to be resolved for further practical use. Here, we provide an in-depth review of the current understanding of algal-based medical application, with a focus on the main pharmaceutical activity and current application stage including in vitro, animal, and clinical studies. Furthermore, we propose some possible solutions to the obstacles that should be overcome for achieving the practical applications of algal-based medicine. Notably, animal and clinical studies on algal drugs and treatments should continue to push forward and expand for promoting the practical applications. Moreover, the developments in interdisciplinary research of algal biology and other disciplines provide new insight for driving algae-based medical application.

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Section: Animal Studiesmentioning

confidence: 99%

Remarkable Natural Biological Resource of Algae for Medical Applications

Dai

Wang²,

Xu³

et al. 2022

Front. Mar. Sci.

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Subacute oral toxicity and bacterial mutagenicity of a mixture of Puerariae radix and Hizikia fusiforme extracts

Youn

Han

Suh

et al. 2021

Drug and Chemical Toxicology

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Identification of Active Compounds of Pueraria Lobata and their Mechanisms of Action by LC-MS/MS and Network Pharmacology

Cao

Liu

2023

CCS

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background: Recent studies have shown that osteoporosis has become a global public health problem and PL is a potential medicine for treatment of osteoporosis. objective: This study describes a rapid method of detecting and identifying the constituents and systematic mechanism of PL based on LC–MS and network pharmacology. method: We explored the compounds and possible pathways of PL affecting the pathological process of osteoporosis base on UHPLC-Q-Orbitrap MS metabolomics. result: A total of 48 compounds including 38 isoflavones, 6 puerosides and 4 others were identified by UHPLC-Q Exactive-Orbitrap MS. The network pharmacological analysis revealed that 28 compounds regulated 19 pathways through 27 targets, including estrogen signaling pathway and NF-kappa B signaling pathway, etc. conclusion: PL may attenuate osteoporosis by regulating estrogen signaling pathway, NF-kappa B signaling pathway, MAPK signaling pathway and PI3K-Akt signaling pathwayand be a potential source of functional food for prevention of osteoporosis.

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Combination ofSargassum fusiformeandPueraria lobataExtracts Alleviates Postmenopausal Symptoms in Ovariectomized Rats

Cited by 3 publications

References 20 publications

Remarkable Natural Biological Resource of Algae for Medical Applications

Remarkable Natural Biological Resource of Algae for Medical Applications

Subacute oral toxicity and bacterial mutagenicity of a mixture of Puerariae radix and Hizikia fusiforme extracts

Identification of Active Compounds of Pueraria Lobata and their Mechanisms of Action by LC-MS/MS and Network Pharmacology

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