Remarkable Natural Biological Resource of Algae for Medical Applications

Dai, Na; Wang, Qiang; Xu, Baisheng; Chen, Hui

doi:10.3389/fmars.2022.912924

Cited by 18 publications

(12 citation statements)

References 132 publications

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“…Finally, compounds 7 (9.9 mg) and 12 (14.5 mg) were isolated from the TP4E fraction (1.9 g) on an RP-18 column eluting with MeOH/water (9/1, vol/vol). Ergosta-7,22-diene-3β,5α,9α-triol (1)…”

Section: Extraction and Purification Of Compoundsmentioning

confidence: 99%

“…The compounds from microalgae have exhibited antibacterial, antifungal, antiviral, antitumor, and anti-inflammatory effects. 1…”

Section: Introductionmentioning

confidence: 99%

“…The compounds from microalgae have exhibited antibacterial, antifungal, antiviral, antitumor, and anti-inflammatory effects. 1 Thraustochytrium species (Thraustochytriaceae family) are suitable for fermentation technology and produce fatty acids and other value-added biocomponents. 2,3 The marine microalga Thraustochytrium pachydermum was isolated from Truong Sa Island, Truong Sa Archipelago, Vietnam in 2021 and is available in GenBank (accession number OL721615).…”

Section: Introductionmentioning

confidence: 99%

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Chemical Constituents From the Marine Microalgae Thraustochytrium pachydermum

Thủy

Hien²,

Ha³

et al. 2023

Natural Product Communications

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Objectives Isolation, structure determination, and antimicrobial activities evaluation of compounds from the methanol extract of the marine microalga Thraustochytrium pachydermum TSL10. Methods Using chromatographic methods to isolate compounds from the methanol extract of the T pachydermum. The chemical structures were elucidated by analyses of HR-ESI-MS and NMR spectral data. The antimicrobial activities of compounds were evaluated using the dilution turbidimetric broth method as the standard protocol published by the Clinical and Laboratory Standard Institute. Results One new sterol, (24 R)-ergosta-7,22-diene-3 β,5 α,9 α-triol (1), and 16 known compounds, ergosta-7,22-diene-3 β,5 α-diol (2), cerevisterol (3), (22 E,24 S)-5 α,6 α-epoxy-ergosta-8(9),22-diene-3 β,7 α-diol (4), ergosterol (5), 5 α,8 α-epidioxyergosta-6,22-diene-3 β-ol (6), linoleic acid (7), 4-((9 Z,12 Z)-octadeca-9,12-dienoyloxy)butanoic acid (8), 1-linoleoyl-sn-glycero-3-phosphocholine (9), cibotiglycerol (10), gingerglycolipid B (11), oleic acid (12), 4-((9Z)-octadec-9-enoyloxy)butanoic acid (13), (2 S)-1- O-(9 Z)-octadec-9-enoyl)-3- O-(6-sulfo-D-quinovopyranosyl)glycerol (14), 6′- O-linoleylsucrose (15), gingerglycolipid C (16), and ( S)-3-stearoyl- sn-glycerol (17) were identified from the marine microalga Thraustochytrium pachydermum TSL10. Sterols 1–6 were found to exhibit significant antimicrobial activities on Gram-( + ) bacteria ( Enterococcus faecalis ATCC29212 , Staphylococcus aureus ATCC25923, and Bacillus cereus ATCC14579) and the yeast ( Candida albicans ATCC10231) with MIC values ranging from 32 to 256 µg/mL. Conclusions The results suggested sterols 1–6 could be potential antimicrobial agents against Gram-( + ) bacteria.

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Section: Extraction and Purification Of Compoundsmentioning

confidence: 99%

“…The compounds from microalgae have exhibited antibacterial, antifungal, antiviral, antitumor, and anti-inflammatory effects. 1…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chemical Constituents From the Marine Microalgae Thraustochytrium pachydermum

Thủy

Hien²,

Ha³

et al. 2023

Natural Product Communications

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show abstract

“…In 2018, the global market for algae products was valued at $ 33.9 billion. It is estimated that it will reach $ 56.5 billion by 2027, with a compound annual growth rate of 6.0 % [12]. Algae market growth is primarily driven by the health and wellness trend, growing dietary supplement industry, vegetarianism, and rising preferences for algae-derived foods.…”

Section: Antioxidantmentioning

confidence: 99%

Bioactive Derivatives from Algae: Properties and Applications in Pharmaceuticals

Merlo,

Conti

2023

Environmental and Climate Technologies

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Using algae metabolites is considered a current and innovative topic of interest. Among the various applying sectors such as food, manufacturing, and environment, these organisms are also characterized by a high therapeutic potential. The influence of biotic and abiotic factors allows the production of different bioactive compounds, such as carbohydrates, polyphenols, proteins, vitamins, sterols, fatty acids and many others. The algal biomass is investigated to discover and develop new possible therapies and nowadays different properties have been determined, like antioxidant, antiviral, antimicrobial, anti-inflammatory, antidiabetic. Typical examples include the application of algae in diabetes mellitus, which is a disease that is continually spreading throughout Europe and the world. Numerous trials are currently underway to develop innovative and effective treatments, as well as several algae are being investigated in order to gain a deeper understanding of this pathology. In recent studies it has been demonstrated that metabolites such as polyphenols, polysaccharides and pigments, by their inhibitory activity, are capable of reducing blood glucose levels and increasing the amount of insulin.

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“…Unicellular microalgae, the microscopic eukaryotic organisms with short life cycles, are capable of generating biomasses via photosynthesis (Dai et al, 2022). For one thing, as a robust source of pigments, proteins, essential fatty acids, etc., microalgae have been regarded as a promising feed additive in aquaculture to boost the growth, immunity, and meat coloration/quality of aquatic animals (Ye et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Comprehensive evaluation of growth characteristics, nitrogen removal capacity, and nutritional properties of three diet microalgae

Zhang

Han²,

Ma³

et al. 2023

Front. Mar. Sci.

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Nitrogen is one of the main pollution sources in aquaculture system. Microalgae are considered as one of the ideal bio-absorbents used in wastewater purification, due to their nitrogen removal capacity and more importantly nutritional value. Nannochloropsis oceanica, Cyclotella atomus, and Conticribra weissflogii are famous as diet microalgae. However, estimation of nitrogen removal capability and concomitant nutritional properties of the three species have been rarely reported, which was performed in this study. N. oceanica, C. atomus, and C. weissflogii were cultivated with two initial nitrate-N concentration, noted as NC (13.85 mg·L–1) and NW (5 mg·L–1) groups, respectively. All the three microalgal strains in NC group showed higher maximum cell density, specific growth rate, and biomass concentration, maximal quantum yield of PSII (Fv/Fm), total Chlorophyll and carotenoids contents than that in NW group. These results confirmed the importance of nitrogen for microalgal biomass generation and photosynthetic performance. From Fv/Fm, N. oceanica has better adaptability towards nitrogen depletion compared to other two selected strains. The three microalgae exhibited significantly stronger nitrate-N absorption efficiencies in NC group at the same timepoint, compared to NW. Analyzing the average amount of nitrate-N absorbed by each cell daily, C. weissflogii gained the largest value, followed successively by C. atomus and N. oceanica, likely due to species specificity. Moreover, three strains removed 90% of nitrate-N within five days and 99% of that within seven days, showing splendid nitrogen removal potentials. These results confirmed the feasibility of removing nitrogen from wastewater with the selected three microalgae. Nutritional properties of microalgal biomass were also investigated. For the three species, lower nitrate-N was beneficial for the production of soluble sugar, total lipid, and saturated fatty acid, while higher nitrate-N led to more soluble protein and polyunsaturated fatty acid. In summary, N. oceanica, C. atomus, and C. weissflogii all showed strong nitrogen removal capacity, whose growth characteristics and nutritional properties varied with nitrogen concentration. In practical application for assimilating nitrogen, these findings could provide some references for the selection of suitable microalgae species in order to satisfy different nutritional requirements of various aquatic animals.

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Remarkable Natural Biological Resource of Algae for Medical Applications

Cited by 18 publications

References 132 publications

Chemical Constituents From the Marine Microalgae Thraustochytrium pachydermum

Chemical Constituents From the Marine Microalgae Thraustochytrium pachydermum

Bioactive Derivatives from Algae: Properties and Applications in Pharmaceuticals

Comprehensive evaluation of growth characteristics, nitrogen removal capacity, and nutritional properties of three diet microalgae

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