Combination of Interleukin 1 Polymorphism and Helicobacter pylori Infection: an Increased Risk of Gastric Cancer in Pakistani Population

Abstract

Helicobacter pylori is one of the major risk factors involved in the development ofgastritis and gastric cancer (GC). H. pylori infection leads to increased production of pro-inflammatory cytokines by the host. Carriage of specific polymorphisms in cytokine genes may be associated with host susceptibility to the development of GC. We investigated the role of host genetic factors including polymorphisms of IL-1B and IL-1RN in correlation with gastritis and GC in H. pylori infected Pakistani population. A total of 230 gastritis cases and 100 GC cases were genotyped for IL 1B-511 and IL-1RN penta-allelic variable number of tandem repeats (VNTRs). A combination of IL-1B-511*T and IL-1RN*2 alleles (OR 19.064; 95% CI 2.319-156.7; p = 0.001) in H. pylori infected individuals had markedly increased risk of GC development. In Pakistani population, an increased risk of GC development is associated with the carriage of IL-1B-511*T and IL-1RN*2 alleles. Synergistic effect of H. pylori infection and IL-1B-511*T/IL-1RN*2 genotypes was also observed in association with significantly higher risk of developing GC. Further prospective and large scale studies are needed to establish the clinical impact of these findings.

Risk factors for recurrence of Helicobacter pylori infection after successful eradication in Chinese children: A prospective, nested case‐control study

“…H pylori can stimulate the production of a variety of cytokines. 29 H pylori can induce the secretion of IL-1β, 30,31 resulting in an increase in IL-1β levels. [32][33][34] The increase in IL-1β level is closely correlated to the occurrence and development of H pylori infection-associated gastritis.…”

The Role of Interleukin-1 in the Pathogenesis of Cancer and its Potential as a Therapeutic Target in Clinical Practice

“…Lastly, intrinsic mutations and polymorphisms in IL-1 genes have been implicated as well in many cancer types as reviewed by Khazim et al [79], though results from studies are sometimes conflicting, and the association is not always clear. Single and IL-1 gene-cluster polymorphisms have been suggested to be associated with cancers such as cervical [80] and ovarian cancer [81], MM [82], esophageal [83], colorectal cancer (CRC) [84], NSCLC [85], pancreatic cancer [86], prostate cancer [87], and gastric cancer [88][89][90].…”

Cytokine Gene Polymorphism and Sepsis

“…Interleukin (IL-1) gene complex consists of IL-1α, IL-1β, IL-1R, and IL-RA genes with five potent polymorphic loci in the structural and promoter regions [40]. These polymorphic loci are associated with susceptibility for sepsis in trauma patients of the Chinese population [41,42] and also associated with other diseases, such as cancer and autoimmunity [43,44]. In our study, we have reported the changes in alleles and genotype frequency at the promoter region of IL-1β (À511) gene.…”