Combination of low-concentration of novel phytoestrogen (8,9)-furanyl-pterocarpan-3-ol from Pachyrhizus erosus attenuated tamoxifen-associated growth inhibition on breast cancer T47D cells

Nurrochmad, Arief; Lukitaningsih, Endang; Monikawati, Ameilinda; Septhea, Dita Brenna; Meiyanto, Edy

doi:10.1016/s2221-1691(13)60167-7

Cited by 4 publications

(6 citation statements)

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“…Bengkoang contains water-soluble fiber, which has potential use as an immunomodulator. In previous studies, isoflavone compounds from P. erosus were proven to inhibit the proliferation of estrogen-dependent breast cancer (T47D) cells in vitro [15]. In the present study, water-soluble from bengkoang enhanced the immune system; thus, it may be further developed as adjuvant therapy.…”

Section: Discussionmentioning

confidence: 57%

Water-Soluble Fiber from Bengkoang (Pachyrhizus erosus (L.) Urban) Tuber Modulates Immune System Activity in Male Mice

et al. 2020

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Our previous study showed that water-soluble fiber from bengkoang (Pachyrizus erosus (L.) Urban) fiber extract (BFE) and bengkoang fiber fraction B (BFE-B) have phagocytic activity and modulation of cytokine production in vitro. The present study evaluates the immunomodulatory effects of water-soluble fibers BFE and BFE-B on male mice induced by hepatitis B vaccine. Thirty mice were divided into six groups and induced by hepatitis B vaccine intraperitoneally on days 7 and 14. The mice were then treated with BFE, BFE-B, levamisole, or sodium carboxymethyl cellulose for 18 days. At the end of the treatments (day 19), phagocytic activity, lymphocyte proliferation, spleen index, cytokine, and immunoglobulin G (IgG) production were determined. The results showed that the water-soluble fiber treatment could significantly increase phagocytic capacity, nitric oxide production, and spleen index. However, BFE-B could modulate tumor necrosis factor (TNF)-α and interleukin (IL)-10 secretion, BFE demonstrated no such effect on cytokine production. Lymphocyte proliferation assay revealed that treatment with 50 mg/kg body weight (BW) BFE and 50 mg/kg BW BFE-B could significantly enhance lymphocyte proliferation. Treatment with 25 and 50 mg/kg BW BFE-B stimulated IgG production. In conclusion, BFE and BFE-B similarly have immunomodulatory effects on innate immune responses. BFE-B further demonstrated immunomodulatory effects on adaptive immune responses.

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Section: Discussionmentioning

confidence: 57%

Water-Soluble Fiber from Bengkoang (Pachyrhizus erosus (L.) Urban) Tuber Modulates Immune System Activity in Male Mice

et al. 2020

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“…From the MTT result, several extracts showed IC50 of lower than 200 μg/mL, with 12 studies showing less than 20 μg/mL and 11 studies were less than 200 μg/mL. However, one study by Nurrochmad et al (2011) showed a very high IC50 of 632 μg/mL. According to the American National Cancer Institute (NCI) and Geran et al (1972), the cytotoxic activity of a crude extract is considered very active if the IC50 value is less than or equal to 20 μg/mL, quite active if the IC50 value is 21 to 200 μg/mL, weak if the IC50 value is 201 to 500 μg/mL, and inactive if the IC50 value is more than 501 μg/mL.…”

Section: Discussionmentioning

confidence: 99%

“…In total, there were 17 studies regarding the anticancer effect of T. flagelliforme extract in breast cancer cells. In addition, two studies were conducted in vivo, and 15 studies conducted were in vitro using several breast cancer cell lines such as MCF-7 human breast cancer cell lines, T47D human breast cancer cell lines, HS578T human breast cancer cell lines, MCM-B2 canine mammary gland benign mixed tumor cell lines, and MCM-IPB-B3 canine mammary gland benign mixed tumor cell lines (Alfarabi et al, 2015;Chan et al, 2005;Chodidjah et al, 2013Chodidjah et al, , 2014Farida et al, 2010;Lai et al, 2010;Nasir & Bohari, 2015;Nobakht et al, 2014;Nurrochmad et al, 2011;Priosoeryanto et al, 2020;Purwaningsih et al, 2016Purwaningsih et al, , 2014Putra et al, 2012;Rostantinata et al, 2018;Sianipar et al, 2019;Widowati & Mudahar, 2009).…”

Section: Breast Cancermentioning

confidence: 99%

“…Studies on cell proliferation found that T. flagelliforme extract could inhibit breast cancer cell proliferation with IC50 ranging from 2.6 to above 100 μg/mL in various breast cancer cell lines (Alfarabi et al, 2015;Chan et al, 2005;Farida et al, 2010;Nasir & Bohari, 2015;Nobakht et al, 2014;Nurrochmad et al, 2011;Purwaningsih et al, 2014;Putra et al, 2011Putra et al, , 2012Sianipar et al, 2019;Widowati & Mudahar, 2009). It was also found that treatment of T. flaggeliforme extract on MCF-7 cells caused increased p21 and caspase-3 expression with no correlation between the two (Putra et al, 2011).…”

Section: Breast Cancermentioning

confidence: 99%

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Anticancer Activity of Typhonium flagelliforme: A Systematic Review

Crystalia

Hillary

2022

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Cancer is a global health issues that can affect anyone. Cancer is treated conventionally with surgery, chemotherapy, radiotherapy, and hormone therapy. However, the high cost of conventional treatments is a burden for cancer patients. Therefore, many cancer patients seek for cheaper yet effective alternative treatments. Typhonium flagelliforme is a taro-like plant that can be found across Indonesia. Numerous researches on the anticancer effect of T. flagelliformehave been conducted. However, a systematic review on the anticancer property of T. flagelliforme is still lacking. Therefore, this review aimed to systematically evaluate the scientific evidence for the anticancer activities in T. flagelliforme. Five databases were used as the search engine using the designated search terms and studies were selected based on the inclusion criteria. The anticancer evaluation in 30 studies selected were conducted in leukemia, lymphoma, breast, oral, cervical, lung, liver, colon, and squamous cell carcinoma. The result showed that T. flagelliforme could inhibit cancer cell proliferation with most of the IC50 are less than 200 μg/mL. T. flagelliformeinduced an increase of caspase-3 and -9, as well as a decrease of the anti-apoptotic Bcl-2 protein expression. The expression of p21 protein was increased after treatment of T. flagelliforme extract while the tyrosine kinase, Ki67, HER2/neu, telomerase, and COX-2 expressions were decreased implying T. flagelliforme could inhibit tumor growth and development. Lastly, T. flagelliforme is also capable in reducing the possibility of cancer cell invasion. Findings suggest that T. flagelliforme is potential to further developed for cancer treatment.

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“…Bukti ilmiah yang mendukung pemanfaatan bengkoang dalam bidang kesehatan antara lain sebagai antioksidan, zat penghambat enzim tirosinase (Lukitaningsih & Holzgrabe, 2014), mencegah hilangnya massa tulang pada tikus yang dibuat model osteoporosis (Nurrochmad et al, 2010), agen kemopreventif (Nurrochmad et al, 2013), penurun kadar gula darah pada hewan uji mencit yang dibuat diabetes dengan diinduksi streptozotocin (Park & Han, 2015), ekstrak fiber bengkoang (BFE) yang bersifat polar menunjukkan aktivitas imunomodulator in vitro maupun in vivo dengan menstimulasi aktivitas fagositosis, meningkatkan produksi sitokin dan imunoglobulin (Kumalasari et al, 2013). Ekstrak fiber bengkoang (BFE) dan fraksi B dari BFE yang merupakan serat larut air dapat memodulasi sistem imun dengan meningkatkan respon imun innate dan adaptive (Baroroh et al, 2020).…”

Section: Pendahuluanunclassified

Aktivitas Imunomodulator Ekstrak Petroleum Eter Umbi Bengkoang (Pachyrhizus erosus) pada Mencit Balb/c yang Diinduksi Vaksin Hepatitis B

Sujono

Nurrochmad

Lukitaningsih

et al. 2022

J. Pharm. Sci. Clin. Res.

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Ekstrak non polar umbi bengkoang (Pachyrhizus erosus) mengandung senyawa fitosterol berupa β-sitosterol yang diduga mempunyai efek imunomodulator in vivo. Tujuan penelitian ini untuk mengetahui pengaruh pemberian ekstrak petroleum eter (EPE) bengkoang terhadap parameter respon imun non spesifik dan spesifik pada mencit Balb/c yang diinduksi vaksin hepatitis B. Hewan uji mencit secara acak dibagi menjadi 4 kelompok. Kelompok I sebagai kontrol negatif, kelompok II diberi perlakuan obat standard levamisol 2,5 mg/kgBB, kelompok III dan IV berturut-turut diberi EPE bengkoang dosis 100 dan 200 mg/kgBB. Perlakuan diberikan secara peroral selama 18 hari. Efek imunomodulator EPE bengkoang dievaluasi berdasarkan aktivitas fagositosis makrofag, proliferasi limfosit, produksi antibodi atau imunoglobulin G (IgG), serta produksi sitokin tumor necrosis factor-α (TNF-α) dan interleukin-10 (IL-10). Hasil penelitian menunjukkan bahwa pemberian EPE bengkoang mampu meningkatkan kapasitas dan indeks fagositosis makrofag serta proliferasi limfosit secara signifikan (p<0,05). Semakin tinggi dosis EPE bengkoang, produksi IgG semakin turun (p<0,05), sementara produksi TNF-α meningkat dan IL-10 turun namun perubahannya tidak signifikan (p>0,05). EPE bengkoang mempunyai efek imunomodulator dengan meningkatkan respon imun non spesifik sedangkan respon imun spesifik (humoral) turun tergantung dosis.

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Combination of low-concentration of novel phytoestrogen (8,9)-furanyl-pterocarpan-3-ol from Pachyrhizus erosus attenuated tamoxifen-associated growth inhibition on breast cancer T47D cells

Cited by 4 publications

References 31 publications

Water-Soluble Fiber from Bengkoang (Pachyrhizus erosus (L.) Urban) Tuber Modulates Immune System Activity in Male Mice

Water-Soluble Fiber from Bengkoang (Pachyrhizus erosus (L.) Urban) Tuber Modulates Immune System Activity in Male Mice

Anticancer Activity of Typhonium flagelliforme: A Systematic Review

Aktivitas Imunomodulator Ekstrak Petroleum Eter Umbi Bengkoang (Pachyrhizus erosus) pada Mencit Balb/c yang Diinduksi Vaksin Hepatitis B

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